8 - Local Field Potentials (LFPs)

Summary

The local field potential (LFP) is the low-pass filtered extracellular potential recorded inside brain tissue. Unlike spikes, which reflect neuronal action potentials and thus the output of neurons, the LFP is believed to predominantly reflect the synaptic inputs to neurons. Here, we use computer simulations and approximate analytical formulas of LFPs from single neurons and populations of neurons to give a comprehensive overview of the various factors that can contribute to shaping the LFP and its frequency content. We consider the effects of neural morphology, intrinsic dendritic filtering, synaptic distributions, synchrony in synaptic inputs, the position of the recording electrode, and possible contributions from action potentials, calcium spikes, NMDA spikes, and active subthreshold dendritic ion channels.