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Chapter 58 - Prophylactic Bilateral Salpingo-oophorectomy

from Section 12 - Miscellaneous

Published online by Cambridge University Press:  24 November 2021

By
Ballari Ghosh ,
Alex Glover  and
Edward Prosser-Snelling
Edited by
Tahir Mahmood ,
Charles Savona-Ventura ,
Ioannis Messinis  and
Sambit Mukhopadhyay
Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Ovarian cancer is the second most common gynaecological malignancy but is the most common cause of gynaecological cancer death. Ovarian cancer screening has not been proven to be associated with statistically significant reduction in mortality from ovarian cancer. However, evidence demonstrates that prophylactic bilateral salpingo-oophorectomy significantly reduces the risk of developing gynaecological and breast cancer in women who carry BRCA1 and BRCA2 mutations.

Moreover, there is 4–20% incidence of histological diagnosis of occult ovarian malignancy found after prophylactic surgery. Identifying and counselling patients with hereditary conditions that predispose them to higher chance of breast and gynaecological cancer is extremely important. Clinical information should include protective measures, fertility implications, surgical premature menopause and its short- and long-term implications and availability of hormone replacement therapy.

Keywords

salpingo-oophorectomyprophylacticcancerhysterectomy
Type
Chapter
Information
The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Gynaecology
 , pp. 499 - 502
Publisher: Cambridge University Press
Print publication year: 2021

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References

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