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Chapter 15 - Thrombosis, air travel and early pregnancy

Published online by Cambridge University Press:  05 October 2010

By
Gillian Norrie  and
Mike Greaves
Edited by
Roy G. Farquharson  and
Mary D. Stephenson
Roy G. Farquharson
Affiliation:
University of Liverpool
Mary D. Stephenson
Affiliation:
University of Chicago
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Summary

Venous thromboembolism (VTE) has a multifactorial pathogenesis involving genetic predisposition, acquired diseases and conditions, and lifestyle and environmental factors. Although the level of risk of VTE associated with air travel has been exaggerated through sensationalized reporting in the mass media, it has nevertheless been established now that long-haul flights represent a risk factor for deep vein thrombosis and pulmonary embolism, including fatal events. Potentially effective measures to reduce the risk of travel-related VTE include enhanced mobility, use of graduated compression hosiery and pharmacological interventions. Low molecular weight heparin (LMWH) is effective in reducing the incidence of VTE post-operatively (by 50-60%) as well as in hospitalized subjects more generally, with little increased risk of bleeding. Based on the low absolute risk of travel-related VTE in the overwhelming majority of women during early pregnancy, pharmacological thromboprophylaxis with LMWH can be justified.

Keywords

colony stimulating factor-1embryo transfergranulocyte-macrophage colony stimulating factorpregnancyrecurrent miscarriageinterleukin-2immunomodulation therapiesin-vitro fertilizationsteroidsuterine natural killer cells
Type
Chapter
Information
Early Pregnancy , pp. 143 - 150
Publisher: Cambridge University Press
Print publication year: 2010

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