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20 - Sickle Cell Pain: Biology, Etiology, and Treatment

from SECTION FIVE - SICKLE CELL DISEASE

Published online by Cambridge University Press:  03 May 2010

Martin H. Steinberg ,
Bernard G. Forget ,
Douglas R. Higgs  and
David J. Weatherall
By
Samir K. Ballas  and
James R. Eckman
Martin H. Steinberg
Affiliation:
Boston University
Bernard G. Forget
Affiliation:
Yale University, Connecticut
Douglas R. Higgs
Affiliation:
MRC Institute of Molecular Medicine, University of Oxford
David J. Weatherall
Affiliation:
Albert Einstein College of Medicine, New York
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Summary

INTRODUCTION

Definition of Acute Pain Episodes

Pain is an unpleasant sensory and emotional experience. Acute pain episodes in sickle cell disease are mildly to excruciatingly unpleasant sensory and emotional experiences that occur episodically and unpredictably in one or many parts of the body, lasting from hours to weeks for which there is no other pathological explanation. Episodes of acute pain are the most common and distressing manifestations of sickle cell disease for the affected individual and their families. Their onset is early in life and unpredictable recurrences cause life-long suffering; they are disruptive to social and psychological functioning; they result in frequent utilization of healthcare resources, and they are a predictor of reduced survival.

Pain can occur anywhere, be localized to one or a few areas, be migratory, or be generalized. Back, chest, extremities, and joints are most often involved. Swelling and tenderness over affected areas and low-grade fever are common. The pain episode occurs in phases with an average length of approximately 10 days in adults.

The pathophysiology of painful episodes is poorly understood despite years of investigation. Observations during acute painful events suggest they result from diffuse ischemia of bones and muscles caused by disruption of blood flow in small and large blood vessels. The pathogenesis of the disruption of blood flow is complex and not well understood and is likely to be related to sickle cell–related vasoocclusion and vasculopathy, whose proximate cause is polymerization of deoxygenated sickle hemoglobin (HbS).

Type
Chapter
Information
Disorders of Hemoglobin
Genetics, Pathophysiology, and Clinical Management
 , pp. 497 - 524
Publisher: Cambridge University Press
Print publication year: 2009

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References

Platt, OS, Thorington, BD, Brambilla, DJ, et al. Pain in sickle cell disease. Rates and risk factors. N Engl J Med. 1991;325:11–16.CrossRefGoogle ScholarPubMed
Treadwell, M, Gil, KM. Psychosocial aspects. In: Embury, S, Hebbel, R, Mohandas, N, Steinberg, M, eds. Sickle Cell Disease: Basic Principles and Clinical Practice. New York: Raven Press, Ltd.; 1994:517–529.Google Scholar
Shapiro, BS, Dinges, DF, Orne, EC, et al. Home management of sickle cell-related pain in children and adolescents: natural history and impact on school attendance. Pain. 1995;61:139–144.CrossRefGoogle ScholarPubMed
Walco, GA, Dampier, CD. Pain in children and adolescents with sickle cell disease: a descriptive study. J Pediatr Psychol. 1990;15:643–658.CrossRefGoogle ScholarPubMed
Diggs, LW. Sickle cell crisis. Am J Clin Pathol. 1965;44:1–19.CrossRefGoogle Scholar
Konotey-Ahulu, FI. The sickle cell diseases. Clinical manifestations including the “sickle crisis.”Arch Intern Med. 1974;133:611–619.CrossRefGoogle ScholarPubMed
Serjeant, GR, Ceulaer, CD, Lethbridge, R, Morris, J, Singhal, A, Thomas, PW. The painful crisis of homozygous sickle cell disease: clinical features. Br J Haematol. 1994;87:586–591.CrossRefGoogle ScholarPubMed
Akinola, NO, Stevens, SM, Franklin, IM, Nash, GB, Stuart, J. Subclinical ischaemic episodes during the steady state of sickle cell anaemia. J Clin Pathol. 1992;45:902–906.CrossRefGoogle ScholarPubMed
Ballas, SK, Smith, ED. Red blood cell changes during the evolution of the sickle cell painful crisis. Blood. 1992;79:2154–2163.Google ScholarPubMed
Beyer, JE, Simmons, , Woods, GM, Woods, PM. A chronology of pain and comfort in children with sickle cell disease. Arch Pediatr Adolesc Med. 1999;153:913–920.CrossRefGoogle ScholarPubMed
Davies, SC. The hospital management of patients with sickle cell disease. Haematologica. 1990;75 Suppl 5:96–106.Google ScholarPubMed
Feldman, F, Zwass, A, Staron, RB, Haramati, N. MRI of soft tissue abnormalities: a primary cause of sickle cell crisis. Skeletal Radiol. 1993;22:501–506.CrossRefGoogle ScholarPubMed
Mankad, VN, Williams, JP, Harpen, MD, et al. Magnetic resonance imaging of bone marrow in sickle cell disease: clinical, hematologic, and pathologic correlations. Blood. 1990;75:274–283.Google ScholarPubMed
Mankad, VN, Yang, YM, Williams, JP, Brogdon, BG. Magnetic resonance imaging of bone marrow in sickle cell patients. Am J Pediatr Hematol Oncol. 1988;10:344–347.CrossRefGoogle ScholarPubMed
Bunn, HF. Pathogenesis and treatment of sickle cell disease. N Engl J Med. 1997;337:762–769.CrossRefGoogle ScholarPubMed
Steinberg, MH. Management of sickle cell disease. N Engl J Med. 1999;340:1021–1030.CrossRefGoogle ScholarPubMed
Embury, SH, Hebbel, RP, Steinberg, MH, Mohandas, N. Pathogenesis of vasoocclusion. In: Embury, SH, Hebbel, RP, Mohandas, N, Steinberg, MH, eds. Sickle Cell Disease: Basic Principles and Clinical Practice. New York: Raven Press, Ltd.; 1994:311–326.Google Scholar
Ballas, SK, Mohandas, N. Sickle red cell microrheology and sickle blood rheology. Microcirculation. 2004;11:209–225.CrossRefGoogle ScholarPubMed
Chiang, EY, Frenette, PS. Sickle cell vasoocclusion. Hematol Oncol Clin North Am. 2005;19:771–784.CrossRefGoogle Scholar
Frenette, PS. Sickle cell vasoocclusion: heterotypic, multicellular aggregations driven by leukocyte adhesion. Microcirculation. 2004;11:167–177.CrossRefGoogle ScholarPubMed
Frenette, PS, Atweh, GF. Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest. 2007;117:850–858.CrossRefGoogle ScholarPubMed
Hebbel, RP, Osarogiagbon, R, Kaul, D. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation. 2004;11:129–151.CrossRefGoogle Scholar
Benjamin, LJ. Nature and treatment of the acute painful episode in sickle cell disease. In: Steinberg, MH, Forget, BG, Higgs, DR, Nagel, RL, eds. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. New York: Cambridge University Press; 2001:671–710.Google Scholar
Embury, S, Hebbel, R, Mohandas, N, Steinberg, M. Sickle cell disease. Basic Principles and Clinical Picture. New York: Raven Press, Ltd.; 1994.Google Scholar
Serjeant, GR. Sickle Cell Disease. 3rd ed. New York: Oxford University Press; 2001.Google ScholarPubMed
Boros, L, Thomas, C, Weiner, WJ. Large cerebral vessel disease in sickle cell anaemia. J Neurol Neurosurg Psychiatry. 1976;39:1236–1239.CrossRefGoogle ScholarPubMed
Powars, D, Wilson, B, Imbus, C, Pegelow, C, Allen, J. The natural history of stroke in sickle cell disease. Am J Med. 1978;65:461–471.CrossRefGoogle ScholarPubMed
Powars, DR. Sickle cell anemia and major organ failure. Hemoglobin. 1990;14:573–598.CrossRefGoogle ScholarPubMed
Hebbel, RP. Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology. Blood. 1991;77:214–237.Google ScholarPubMed
Francis, RB, Johnson, CS. Vascular occlusion in sickle cell disease: current concepts and unanswered questions. Blood. 1991;77:1405–1414.Google ScholarPubMed
Fields, HL. Pain. New York: McGraw-Hill; 1987.Google Scholar
Katz, N, Ferrante, FM. Nociception. In: Ferrante, FM, VadeBoncoeur, TR, eds. Post Operative Pain Management. New York: Churchill Livingstone; 1993:17–67.Google Scholar
Kaul, DK. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J Clin Invest. 2000;106:411–420.CrossRefGoogle ScholarPubMed
Platt, OS. Sickle cell anemia as an inflammatory disease. J Clin Invest. 2000;106:337–338.CrossRefGoogle ScholarPubMed
Cousins, MJ, John, J. Bonica distinguished lecture. Acute pain and the injury response: immediate and prolonged effects. Reg Anesth. 1989;14:162–179.Google ScholarPubMed
Cousins, MJ. Acute post operative pain. In: Wall, PD, Melzack, R, eds. Textbook of Pain. New York: Churchill Livingstone; 1994:357–385.Google Scholar
McMahon, SB, Koltzeninburg, M, eds. In: Wall and Melzack's Textbook of Pain. 5th ed. New York: Churchill Livingstone; 2006.
Loeser, JD, Butler, SH, Chapman, CR, Turk, DC, eds. Bonica's Management of Pain. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2001.Google Scholar
Ballas, SK. The neurobiology and treatment of pain in sickle cell disease. In: Embury, SH, Hebbel, RP, Mohandas, N, Steinberg, MH, eds. Sickle Cell Disease: Scientific Principles and Clinical Practice. New York: Raven Press; 1994:745–772.Google Scholar
Ballas, SK. Sickle cell disease. In: Rakel, RE, ed. Conn's Current Therapy. Philadelphia: WB Saunders; 1995:318–327.Google Scholar
Meyer, RA, Ringkamp, M, Campbell, JN, Raja, SN. Peripheral mechanisms of cutaneous nociception. In: McMahon, SB, Koltzeninburg, M, eds. Wall and Melzack's Textbook of Pain. 5th ed. New York: Churchill Livingston; 2006:16.Google Scholar
Dunn, MJ, Hood, VL. Prostaglandins and the kidney. Am J Physiol. 1977;233:169–184.Google ScholarPubMed
Dyck, PJ, ed. Peripheral Neuropathy. Philadelphia: Saunders; 1975.PubMed
Ballas, SK. Sickle cell pain. Progress in Pain Research and Management. Seattle: IASP Press; 1998.Google Scholar
Melzack, R. Pain questionnaire: major properties and scoring. Pain. 1975;1:277–299.CrossRefGoogle ScholarPubMed
Wall, PD, Melzack, R, eds. Textbook of Pain. 3rd ed. New York: Churchill Livingstone; 1994.Google Scholar
Anderson, P, Morris, R, Amaral, D, et al. The Hippocampus Book. New York: Oxford University Press; 2007.Google Scholar
Choi, DS, Choi, DY, Whittington, RA, Nedeljkovic, SS. Sudden amnesia resulting in pain relief: the relationship between memory and pain. Pain. 2007;132:206–210.CrossRefGoogle ScholarPubMed
Basbaum, AI. The generation and control of pain. In: Rosenberg, RN, Grossman, RG, Schochet, SS, Heinz, ER, Willis, WD, eds. The Clinical Neurosciences, Neurobiology. New York: Churchill Livingstone; 1983:V301–V24.Google Scholar
Basbaum, AI, Fields, HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci. 1984;7:309–338.CrossRefGoogle ScholarPubMed
Ballas, SK, Lusardi, M. Hospital readmission for adult acute sickle cell painful episodes: frequency, etiology, and prognostic significance. Am J Hematol. 2005;79:17–25.CrossRefGoogle ScholarPubMed
Vichinsky, EP, Johnson, R, Lubin, BH. Multidisciplinary approach to pain management in sickle cell disease. Am J Pediatr Hematol Oncol. 1982;4:328–333.Google ScholarPubMed
Bonds, DR. Three decades of innovation in the management of sickle cell disease: the road to understanding the sickle cell disease clinical phenotype. Blood Rev. 2005;19:99–110.CrossRefGoogle ScholarPubMed
Steinberg, MH. Predicting clinical severity in sickle cell anaemia. Br J Haematol. 2005;129:465–481.CrossRefGoogle ScholarPubMed
Powars, DR. Sickle cell anemia: beta s-gene-cluster haplotypes as prognostic indicators of vital organ failure. Semin Hematol. 1991;28:202–208.Google ScholarPubMed
Udezue, E, Girshab, AM. Differences between males and females in adult sickle cell pain crisis in eastern Saudi Arabia. Ann Saudi Med. 2004;24:179–182.CrossRefGoogle ScholarPubMed
Ballas, SK, Larner, J, Smith, ED, Surrey, S, Schwartz, E, Rappaport, EF. Rheologic predictors of the severity of the painful sickle cell crisis. Blood. 1988;72:1216–1223.Google ScholarPubMed
Lande, WM, Andrews, DL, Clark, MR, et al. The incidence of painful crisis in homozygous sickle cell disease: correlation with red cell deformability. Blood. 1988;72:2056–2059.Google ScholarPubMed
Baum, KF, Dunn, DT, Maude, GH, Serjeant, GR. The painful crisis of homozygous sickle cell disease. A study of the risk factors. Arch Intern Med. 1987;147:1231–1234.CrossRefGoogle ScholarPubMed
Taylor, JG, Nolan, VG, Mendelsohn, L, Kato, GJ, Gladwi, MT, Steinberg, MH. Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain PLoS One. 2008; 3(5)e 2095.
Hargrave, DR, Wade, A, Evans, JP, Hewes, DK, Kirkham, FJ. Nocturnal oxygen saturation and painful sickle cell crises in children. Blood. 2003;101:846–848.CrossRefGoogle ScholarPubMed
Schall, JI, Zemel, BS, Kawchak, DA, Ohene-Frempong, K, Stallings, VA. Vitamin A status, hospitalizations, and other outcomes in young children with sickle cell disease. J Pediatr. 2004;145:99–106.CrossRefGoogle ScholarPubMed
Gil, KM, Carson, JW, Porter, LS, Scipio, C, Bediako, SM, Orringer, E. Daily mood and stress predict pain, health care use, and work activity in African American adults with sickle-cell disease. Health Psychol. 2004;23:267–274.CrossRefGoogle ScholarPubMed
Amjad, H, Bannerman, RM, Judisch, JM. Letter: Sickling pain and season. Br Med J. 1974;2:54.CrossRefGoogle ScholarPubMed
Ibrahim, AS. Relationship between meteorological changes and occurrence of painful sickle cell crises in Kuwait. Trans R Soc Trop Med Hyg. 1980;74:159–161.CrossRefGoogle ScholarPubMed
Redwood, AM, Williams, EM, Desal, P, Serjeant, GR. Climate and painful crisis of sickle-cell disease in Jamaica. Br Med J. 1976;1:66–68.CrossRefGoogle ScholarPubMed
Kehinde, MO, Marsh, JC, Marsh, GW. Sickle cell disease in North London. Br J Haematol. 1987;66:543–547.CrossRefGoogle ScholarPubMed
Seeler, RA. Non-seasonality of sickle-cell crisis. Lancet. 1973;2:743.CrossRefGoogle ScholarPubMed
Slovis, CM, Talley, JD, Pitts, RB. Non relationship of climatologic factors and painful sickle cell anemia crisis. J Chronic Dis. 1986;39:121–126.CrossRefGoogle ScholarPubMed
Smith, WR, Coyne, P, Smith, VS, Mercier, B. Temperature changes, temperature extremes, and their relationship to emergency department visits and hospitalizations for sickle cell crisis. Pain Manage Nurs. 2003;4:106–111.CrossRefGoogle ScholarPubMed
Jones, S, Duncan, ER, Thomas, N, et al. Windy weather and low humidity are associated with an increased number of hospital admissions for acute pain and sickle cell disease in an urban environment with a maritime temperate climate. Br J Haematol. 2005;131:530–533.CrossRefGoogle Scholar
Yallop, D, Duncan, ER, Norris, E, et al. The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment. Br J Haematol. 2007;136:844–848.CrossRefGoogle Scholar
Nolan, VG, Zhang, Y, Lash, T, Sebastiani, P, Steinberg, MH. Association of wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study. Br J Haematol. 2008; 143(3) 433–438.CrossRefGoogle ScholarPubMed
Resar, LM, Oski, FA. Cold water exposure and vaso-occlusive crises in sickle cell anemia. J Pediatr. 1991;118:407–409.CrossRefGoogle ScholarPubMed
Dampier, C, Ely, E, Brodecki, D, O'Neal P. Home management of pain in sickle cell disease: a daily diary study in children and adolescents. J Pediatr Hematol Oncol. 2002;24:643–647.CrossRefGoogle ScholarPubMed
Anie, KA, Steptoe, A, Bevan, DH. Sickle cell disease: pain, coping and quality of life in a study of adults in the UK. Br J Health Psychol. 2002;7:331–344.CrossRefGoogle Scholar
Fuggle, P, Shand, PA, Gill, LJ, Davies, SC. Pain, quality of life, and coping in sickle cell disease. Arch Dis Child. 1996;75:199–203.CrossRefGoogle ScholarPubMed
Porter, LS, Gil, KM, Sedway, JA, Ready, J, Workman, E, Thompson, RJ. Pain and stress in sickle cell disease: an analysis of daily pain records. Int J Behav Med. 1998;5:185–203.CrossRefGoogle ScholarPubMed
Westerman, MP, Bailey, K, Freels, S, Schlegel, R, Williamson, P. Assessment of painful episode frequency in sickle-cell disease. Am J Hematol. 1997;54:183–188.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Smith, WR, Penberthy, LT, Bovbjerg, VE, et al. Daily assessment of pain in adults with sickle cell disease. Ann Intern Med. 2008;148:94–101.CrossRefGoogle ScholarPubMed
Akinola, NO, Stevens, SM, Franklin, IM, Nash, GB, Stuart, J. Rheological changes in the prodromal and established phases of sickle cell vaso-occlusive crisis. Br J Haematol. 1992;81:598–602.CrossRefGoogle ScholarPubMed
Ballas, SK. The sickle cell painful crisis in adults: phases and objective signs. Hemoglobin. 1995;19:323–333.CrossRefGoogle ScholarPubMed
Jacob, E, Beyer, JE, Miaskowski, C, Savedra, M, Treadwell, M, Styles, L. Are there phases to the vaso-occlusive painful episode in sickle cell disease?J Pain Symptom Manage. 2005;29:392–400.CrossRefGoogle ScholarPubMed
Neuman, HN, Diggs, LW, Schlenker, FS, et al. Increased urinary porphyrin excretion in sickle cell crises. Proc Soc Exp Biol Med. 1966;123:1–4.CrossRefGoogle Scholar
Schumaker, HR. Rheumatological manifestation of sickle disease and other haemoglobinopathies. Clin Rheum Dis. 1975;1:37–52.Google Scholar
Schumacher, HR, Andrews, R, McLaughlin, G. Arthropathy in sickle-cell disease. Ann Intern Med. 1973;78:203–211.CrossRefGoogle ScholarPubMed
Brugsch, HG, Gill, D. Polyarthritis in sickle cell anemia. N Engl J Med. 1944;231:291–292.CrossRefGoogle Scholar
Espinoza, LR, Spilberg, I, Osterland, CK. Joint manifestations of sickle cell disease. Medicine (Baltimore). 1974;53:295–305.CrossRefGoogle ScholarPubMed
Miller, RL, Webster, ME, Melmon, KL. Interaction of leukocytes and endotoxin with the plasmin and kinin systems. Eur J Pharmacol. 1975;33:53–60.CrossRefGoogle ScholarPubMed
Dorwart, BB, Gabuzda, TG. Symmetric myositis and fasciitis: a complication of sickle cell anemia during vasoocclusion. J Rheumatol. 1985;12:590–595.Google ScholarPubMed
Valeriano-Marcet, J, Kerr, LD. Myonecrosis and myofibrosis as complications of sickle cell anemia. Ann Intern Med. 1991;115:99–101.CrossRefGoogle ScholarPubMed
Schumacher, HR, Murray, WM, Dalinka, MK. Acute muscle injury complicating sickle cell crisis. Semin Arthritis Rheum. 1990;19:243–7.CrossRefGoogle ScholarPubMed
Walker, BK, Brownstein, PK, Burka, ER, Ballas, SK. Urinary retention in sickle cell syndromes. Urology. 1980;16:33–35.CrossRefGoogle ScholarPubMed
Ballas, SK, Marcolina, MJ. Hyperhemolysis during the evolution of uncomplicated acute painful episodes in patients with sickle cell anemia. Transfusion. 2006;46:105–110.CrossRefGoogle ScholarPubMed
Buchanan, GR, Glader, BE. Leukocyte counts in children with sickle cell disease. Comparative values in the steady state, vaso-occlusive crisis, and bacterial infection. Am J Dis Child. 1978;132:396–398.CrossRefGoogle ScholarPubMed
Billett, HH, Nagel, RL, Fabry, ME. Evolution of laboratory parameters during sickle cell painful crisis: evidence compatible with dense red cell sequestration without thrombosis. Am J Med Sci. 1988;296:293–298.CrossRefGoogle ScholarPubMed
Green, D, Kwaan, HRG. Impaired fibrinolysis in sickle cell disease. Relation to crisis and infection. Thromb Diath Haemorrh. 1970;24:10–16.Google ScholarPubMed
Haut, MJ, Cowan, DH, Harris, JW. Platelet function and survival in sickle cell disease. J Lab Clin Med. 1973;82:44–53.Google ScholarPubMed
Kenny, MW, George, AJ, Stuart, J. Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism. J Clin Pathol. 1980;33:622–625.CrossRefGoogle ScholarPubMed
Billett, HH, Fabry, ME, Nagel, RL. Hemoglobin distribution width: a rapid assessment of dense red cells in the steady state and during painful crisis in sickle cell anemia. J Lab Clin Med. 1988;112:339–344.Google ScholarPubMed
Sar, A. The sudden rise in platelets and reticulocytes in sickle cell crises. Trop Geogr Med. 1970;22:30–40.Google ScholarPubMed
Gordon, PA, Breeze, GR, Mann, JR, Stuart, J. Coagulation fibrinolysis in sickle-cell disease. J Clin Pathol. 1974;27:485–489.CrossRefGoogle ScholarPubMed
Alkjaersig, N, Fletcher, A, Joist, H, Chaplin, H, Jr. Hemostatic alterations accompanying sickle cell pain crises. J Lab Clin Med. 1976;88:440–449.Google ScholarPubMed
Jacob, E, Miaskowski, C, Savedra, M, Beyer, JE, Treadwell, M, Styles, L. Changes in intensity, location, and quality of vaso-occlusive pain in children with sickle cell disease. Pain. 2003;102:187–193.CrossRefGoogle ScholarPubMed
Jacob, E, Mueller, BU. Pain experience of children with sickle cell disease who had prolonged hospitalizations for acute painful episodes. Pain Med. 2008;9:13–21.CrossRefGoogle ScholarPubMed
Tomer, A, Harker, , Kasey, S, Eckman, JR. Thrombogenesis in sickle cell disease. J Lab Clin Med. 2001;137:398–407.CrossRefGoogle ScholarPubMed
Frei-Jones, MJ, DeBaun, MR. Hospital readmission within 30 days: a new benchmark for quality care among children with sickle cell disease. Blood. 2007;11:3403a.Google Scholar
Walraven, C, Mamdani, M, Fang, J, Austin, PC. Continuity of care and patient outcomes after hospital discharge. J Gen Intern Med. 2004;19:624–31.CrossRefGoogle ScholarPubMed
Forster, AJ, Murff, HJ, Peterson, JF, Gandhi, TK, Bates, DW. The incidence and severity of adverse events affecting patients after discharge from the hospital. Ann Intern Med. 2003;138:161–167.CrossRefGoogle ScholarPubMed
Cordeiro, NJ, Oniyangi, O. Phytomedicines (medicines derived from plants) for sickle cell disease. Cochrane Database Syst Rev. 2004:CD004448.CrossRefGoogle ScholarPubMed
Brousseau, DC, Scott, JP, Hillery, CA, Panepinto, JA. The effect of magnesium on length of stay for pediatric sickle cell pain crisis. Acad Emerg Med. 2004;11:968–972.CrossRefGoogle ScholarPubMed
Benjamin, LJ, Dampier, CD, Jacox, A, et al. Guideline for the Management of Acute and Chronic Pain in Sickle Cell Disease. In: American Pain Society Clinical Practice Guidelines Series No 1. Glenview, IL: American Pain Society; 1999.Google Scholar
Morgan, MT. Use of meperidine as the analgesic of choice in treating pain from acute painful sickle cell crisis. Ann Emerg Med. 2008;51:202–203.CrossRefGoogle ScholarPubMed
Howland, MA, Goldfrank, LR. Why meperidine should not make a comeback in treating patients with sickle cell disease. Ann Emerg Med. 2008;51:203–205.CrossRefGoogle Scholar
Ballas, SK. Meperidine for acute sickle cell pain in the emergency department: revisited controversy. Ann Emerg Med. 2008;51:217.CrossRefGoogle ScholarPubMed
Tobin, DL, Holroyd, KA, Reynolds, RV, Wigal, JK. The hierarchical factor structure of the coping strategies inventory. Cognitive Ther Res. 1989;13:343–361.CrossRefGoogle Scholar
Zsebik, G, Riordan, MA, Berman, B, Villela, A. Low risk of meperidine-induced seizures in children with sickle cell disease [abstract]. Pediatr Blood Cancer. 2007;48:612.Google Scholar
Chulamokha, L, Scholand, SJ, Riggio, JM, Ballas, SK, Horn, D, DeSimone, JA. Bloodstream infections in hospitalized adults with sickle cell disease: a retrospective analysis. Am J Hematol. 2006;81:723–728.CrossRefGoogle ScholarPubMed
Koppert, W. Opioid-induced hyperalgesia – Pathophysiology and clinical relevance. Acute Pain. 2007;9:21–34.CrossRefGoogle Scholar
Klepstad, P, Dale, O, Skorpen, F, Borchgrevink, PC, Kaasa, S. Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005;49:902–908.CrossRefGoogle ScholarPubMed
Graham, AW, Schultz, TK, Mayo-Smith, MF, Ries, RK. Principles of Addiction Medicine. 3rd ed. Chevy Chase, MD: American Society of Addiction Medicine; 2003.Google Scholar
Uhl, GR, Sora, I, Wang, Z. The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses. Proc Natl Acad Sci USA. 1999;96:7752–7755.CrossRefGoogle ScholarPubMed
Compton, P, Geschwind, DH, Alarcon, M. Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction. Am J Med Genet B Neuropsychiatr Genet. 2003;121:76–82.CrossRefGoogle Scholar
Klepstad, P, Rakvag, TT, Kaasa, S, et al. The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta Anaesthesiol Scand. 2004;48:1232–1239.CrossRefGoogle Scholar
Mehta, S, Kutlar, F, Bailey, L, et al. Mu opioid receptor 1 (MOR 1) polymorphisms among patients with sickle cell disease. Oral presentation. In: 27th Annual Meeting of the National Sickle Cell Disease Program. Los Angeles, CA; April 18–21, 2004.Google Scholar
Darbari, DS, Minniti, CP, Rana, S, Anker, J. Pharmacogenetics of morphine: potential implications in sickle cell disease. Am J Hematol. 2008;83:233–236.CrossRefGoogle ScholarPubMed
Darbari, DS, Schaik, RH, Capparelli, EV, Rana, S, McCarter, R, Anker, J. UGT2B7 promoter variant -840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol. 2008;83:200–202.CrossRefGoogle ScholarPubMed
Kopecky, EA, Jacobson, S, Joshi, P, Koren, G. Systemic exposure to morphine and the risk of acute chest syndrome in sickle cell disease. Clin Pharmacol Ther. 2004;75:140–146.CrossRefGoogle ScholarPubMed
Buchanan, ID, Woodward, M, Reed, GW. Opioid selection during sickle cell pain crisis and its impact on the development of acute chest syndrome. Pediatr Blood Cancer. 2005;45:716–724.CrossRefGoogle ScholarPubMed
Weber, ML, Hebbel, RP, Gupta, K. Morphine induces kidney injury in transgenic sickle cell mice. Blood. 2005;106:884a–5a.Google Scholar
King, T, Vardanyan, A, Majuta, L, et al. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain. 2007;132:154–168.CrossRefGoogle Scholar
Poonawala, T, Levay-Young, BK, Hebbel, RP, Gupta, K. Opioids heal ischemic wounds in the rat. Wound Repair Regen. 2005;13:165–174.CrossRefGoogle ScholarPubMed
Ferrante, MF. Nonsteroidal anti-inflammatory drugs. In: Ferrante, MF, Vade Bancoeur, TR, eds. Post Operative Pain Management. New York: Churchill Livingstone; 1993a:133–143.Google Scholar
Perlin, E, Finke, H, Castro, O, et al. Enhancement of pain control with ketorolac tromethamine in patients with sickle cell vaso-occlusive crisis. Am J Hematol. 1994;46:43–47.CrossRefGoogle ScholarPubMed
Crain, SM, Shen, KF. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment. Proc Natl Acad Sci USA. 1995;92:10540–10544.CrossRefGoogle ScholarPubMed
Winkelmuller, M, Winkelmuller, W. Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. J Neurosurg. 1996;85:458–467.CrossRefGoogle ScholarPubMed
Definitions Related to the Use of Opioids for the Treatment of Pain. American Academy of Pain Medicine American Pain Society American Academy of Addiction Medicine 2001. Available at http://www.ama-assn.org/ama1/pub/upload/mm/455/opioiddefinitions.pdf. Accessed March 31, 2008.
Benjamin, LJ, Payne, R. Pain in sickle cell disease: a multidimensional construct. In: Pace, B, ed. Renaissance of Sickle Cell Disease Research in the Genomic Era. London: Imperial College Press; 2007:99–118.Google Scholar
Mercadante, S, Ferrera, P, Villari, P, Arcuri, E. Hyperalgesia: an emerging iatrogenic syndrome. J Pain Symptom Manage. 2003;26:769–775.CrossRefGoogle ScholarPubMed
Woolf, CJ, Salter, MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288:1765–1769.CrossRefGoogle ScholarPubMed
Gottschalk, A, Smith, DS. New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001;63:1979–1984.Google ScholarPubMed
Baliki, MN, Geha, PY, Apkarian, AV, Chialvo, DR. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. J Neurosci. 2008;28:1398–1403.CrossRefGoogle ScholarPubMed
Song, I, Huganir, RL. Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci. 2002;25:578–588.CrossRefGoogle ScholarPubMed
Carroll, RC, Beattie, EC, Zastrow, M, Malenka, RC. Role of AMPA receptor endocytosis in synaptic plasticity. Nat Rev Neurosci. 2001;2:315–324.CrossRefGoogle ScholarPubMed
Perez-Otano, I, Ehlers, MD. Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci. 2005;28:229–238.CrossRefGoogle ScholarPubMed
Morishita, W, Marie, H, Malenka, RC. Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses. Nat Neurosci. 2005;8:1043–1050.CrossRefGoogle ScholarPubMed
Marchand, F, Perretti, M, McMahon, SB. Role of the immune system in chronic pain. Nat Rev Neurosci. 2005;6:521–532.CrossRefGoogle ScholarPubMed
Nakajima, K, Kohsaka, S. Microglia: activation and their significance in the central nervous system. J Biochem. 2001;130:169–175.CrossRefGoogle ScholarPubMed
Deleo, JA, Sorkin, L, Watkins, L, eds. Immune and Glial Regulation of Pain. Seattle: IASP Press; 2007.Google Scholar
Katz, JL, Higgins, ST. The validity of the reinstatement model of craving and relapse to drug use. Psychopharmacology. 2003;168:21–30.CrossRefGoogle ScholarPubMed
Boyer, EW, Shannon, MT. The serotonin syndrome. N Engl J Med. 2005;352:1112–1120.CrossRefGoogle ScholarPubMed
,NIH. The Management of Sickle Cell Disease. National Heart, Lung and Blood Institute, No. 02-2117. 4th ed. Washington DC: National Institutes of Health; 2002.
Benjamin, LJ, Dampier, CD, Jacox, A, et al. Guideline for the Management of Acute and Chronic Pain in Sickle-Cell Disease. Glenview, IL: American Pain Society; 1999.Google Scholar
Sickle Cell Education Center. Georgia Comprehensive Sickle Cell Center, 2006. Available at www.scinfo.org. Accessed March 3, 2008.
Dunlop, RJ, Bennett, KC. Pain management for sickle cell disease. Cochrane Database Syst Rev. 2006:CD003350.CrossRefGoogle ScholarPubMed
Gil, KM, Carson, JW, Sedway, JA, Porter, LS, Schaeffer, JJ, Orringer, E. Follow-up of coping skills training in adults with sickle cell disease: analysis of daily pain and coping practice diaries. Health Psychol. 2000;19:85–90.CrossRefGoogle ScholarPubMed
Gil, KM, Thompson, RJ, Keith, BR, Tota-Faucette, M, Noll, S, Kinney, TR. Sickle cell disease pain in children and adolescents: change in pain frequency and coping strategies over time. J Pediatr Psychol. 1993;18:621–637.CrossRefGoogle ScholarPubMed
WHO Pain Ladder. World Health Organization, 2008. Available at http://www.who.int/cancer/palliative/painladder/en/. Accessed March 8, 2008.
Jacox, A, Carr, DB, Payne, R. New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med. 1994;330:651–655.CrossRefGoogle ScholarPubMed
Epstein, K, Yuen, E, Riggio, JM, Ballas, SK, Moleski, SM. Utilization of the office, hospital and emergency department for adult sickle cell patients: a five-year study. J Natl Med Assoc. 2006;98:1109–1113.Google ScholarPubMed
Adewoye, AH, Nolan, V, McMahon, L, Ma, Q, Steinberg, MH. Effectiveness of a dedicated day hospital for management of acute sickle cell pain. Haematologica. 2007;92:854–855.CrossRefGoogle ScholarPubMed
Benjamin, LJ, Swinson, GI, Nagel, RL. Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises. Blood. 2000;95:1130–1136.Google ScholarPubMed
The Georgia Comprehensive Sickle Cell Center at Grady Health System in Atlanta, Georgia: Center Description and Services. 2006. Available at http://www.scinfo.org/.
Wright, J, Bareford, D, Wright, C, et al. Day case management of sickle pain: 3 years experience in a UK sickle cell unit. Br J Haematol. 2004;126:878–80.CrossRefGoogle Scholar
Beyer, J, Platt, A, Kinney, T. Assessment of Pain in Adults and Children with Sickle Cell Disease. Mt. Desert, ME: New England Regional Genetics Group; 1994.Google Scholar
Shapiro, B, Schechter, NL, Ohene-Frempong, K. The Genetic Resource, Sickle Cell Related Pain: Assessment and Management. Mt. Desert, ME: New England Regional Genetics Group; 1994.Google Scholar
Frei-Jones, MJ, Baxter, AL, Rogers, ZR, Buchanan, GR. Vaso-occlusive episodes in older children with sickle cell disease: emergency department management and pain assessment. J Pediatr. 2008;152:281–285.CrossRefGoogle ScholarPubMed
Ballas, SK. Current issues in sickle cell pain and its management. Hematology Am Soc Hematol Educ Program. 2007; 110: 97–105.Google Scholar
Tanabe, P, Myers, R, Zosel, A, et al. Emergency department management of acute pain episodes in sickle cell disease. Acad Emerg Med. 2007;14:419–425.CrossRefGoogle ScholarPubMed
Pain Episodes. Georgia Comprehensive Sickle Cell Center, 2006. Accessed at http://www.scinfo.org/painepi.htm.
The Georgia Comprehensive Sickle Cell Center at Grady Health System in Atlanta, Georgia 2006. (Accessed 2008)
Payne, R.Pain management is sickle cell disease: rationale and techniques. Ann NY Acad Sci. 1989;565:189–206.CrossRefGoogle ScholarPubMed
Platt, A, Eckman, JR, Beasley, J, Miller, G. Treating sickle cell pain: an update from the Georgia comprehensive sickle cell center. J Emerg Nurs. 2002;28:297–303.CrossRefGoogle ScholarPubMed
Gonzalez, ER, Bahal, N, Hansen, , et al. Intermittent injection vs patient-controlled analgesia for sickle cell crisis pain. Comparison in patients in the emergency department. Arch Intern Med. 1991;151:1373–1378.CrossRefGoogle ScholarPubMed
Holbrook, CT. Patient-controlled analgesia pain management for children with sickle cell disease. J Assoc Acad Minor Phys. 1990;1:93–96.Google ScholarPubMed
Melzer, MD, Walsh, CM, Lea, G, Hillery, CA, Scott, JP. Patient-controlled analgesia for sickle cell pain crisis in a pediatric emergency department. Pediatr Emerg Care. 2004;20:2–4.CrossRefGoogle Scholar
Trentadue, NO, Kachoyeanos, MK, Lea, G. A comparison of two regimens of patient-controlled analgesia for children with sickle cell disease. J Pediatr Nurs. 1998;13:15–9.CrossRefGoogle ScholarPubMed
Beers, EJ, Tuijn, CF, Nieuwkerk, PT, Friederich, PW, Vranken, JH, Biemond, BJ. Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crisis in sickle cell disease, a randomized controlled trial. Am J Hematol. 2007;82:955–60.CrossRefGoogle ScholarPubMed
Schechter, NL, Berrien, FB, Katz, SM. PCA for adolescents in sickle-cell crisis. Am J Nurs. 1988;88:719, 21–2.Google ScholarPubMed
Schechter, NL, Berrien, FB, Katz, SM. The use of patient-controlled analgesia in adolescents with sickle cell pain crisis: a preliminary report. J Pain Symptom Manage. 1988;3:109–113.CrossRefGoogle ScholarPubMed
Ballas, SK. Ethical issues in the management of sickle cell pain. Am J Hematol. 2001;68:127–132.CrossRefGoogle ScholarPubMed
Elander, J, Lusher, J, Bevan, D, Telfer, P, Burton, B. Understanding the causes of problematic pain management in sickle cell disease: evidence that pseudoaddiction plays a more important role than genuine analgesic dependence. J Pain Symptom Manage. 2004;27:156–169.CrossRefGoogle Scholar
Elander, J, Marczewska, M, Amos, R, Thomas, A, Tangayi, S. Factors affecting hospital staff judgments about sickle cell disease pain. J Behav Med. 2006;29:203–214.CrossRefGoogle ScholarPubMed
Elander, J, Midence, K. A review of evidence about factors affecting quality of pain management in sickle cell disease. Clin J Pain. 1996;12:180–193.CrossRefGoogle ScholarPubMed
Armstrong, FD, Pegelow, CH, Gonzalez, JC, Martinez, A. Impact of children's sickle cell history on nurse and physician ratings of pain and medication decisions. J Pediatr Psychol. 1992;17:651–164.CrossRefGoogle ScholarPubMed
Todd, KH, Green, C, Bonham, VL, Haywood, C, Ivy, E. Sickle cell disease related pain: crisis and conflict. J Pain 2006;7:453–458.CrossRefGoogle ScholarPubMed
Ballas, SK. Current issues in sickle cell pain and its management. Hematology Am Soc Hematol Educ Program. 2007;2007:97–105.Google Scholar
Quill, TE. Partnerships in patient care: a contractual approach. Ann Intern Med. 1983;98:228–234.CrossRefGoogle ScholarPubMed
Donovan, MI, Evers, K, Jacobs, P, Mandleblatt, S. When there is no benchmark: designing a primary care-based chronic pain management program from the scientific basis up. J Pain Symptom Manage. 1999;18:38–48.CrossRefGoogle ScholarPubMed
Gil, KM, Carson, JW, Porter, LS, et al. Daily stress and mood and their association with pain, health-care use, and school activity in adolescents with sickle cell disease. J Pediatr Psychol. 2003;28:363–373.CrossRefGoogle ScholarPubMed
Smith, WR, Bovbjerg, VE, Penberthy, LT, et al. Understanding pain and improving management of sickle cell disease: the PiSCES study. J Natl Med Assoc. 2005;97:183–93.Google ScholarPubMed
Ennis, JT, Serjeant, GR, Middlemiss, H. Homozygous sickle cell disease in Jamaica. Br J Radiol. 1973;46:943–950.CrossRefGoogle ScholarPubMed
Milner, PF, Kraus, AP, Sebes, JI, et al. Sickle cell disease as a cause of osteonecrosis of the femoral head. N Engl J Med. 1991;325:1476–1481.CrossRefGoogle ScholarPubMed
Milner, PF, Kraus, AP, Sebes, JI, et al. Osteonecrosis of the humeral head in sickle cell disease. Clin Orthop Rel Res. 1993:136–143.Google ScholarPubMed
Riggs, W, Rockett, JF. Roentgen chest findings in childhood sickle cell anemia. A new vertebral body finding. Am J Roentgenol Radium Ther Nucl Med. 1968;104:838–845.CrossRefGoogle ScholarPubMed
Diggs, LW. Bone and joint lesions in sickle-cell disease. Clin Orthop Rel Res. 1967;52:119–143.CrossRefGoogle ScholarPubMed
Diggs, LW, ed. Anatomic Lesions in Sickle Cell Anemia. St. Louis: C.V. Mosby Co; 1973.Google Scholar
Neumayr, LD, Aguilar, C, Earles, AN, et al. Physical therapy alone compared with core decompression and physical therapy for femoral head osteonecrosis in sickle cell disease. Results of a multicenter study at a mean of three years after treatment. J Bone Joint Surg Am. 2006;88:2573–2582.CrossRefGoogle Scholar
Hernigou, P, Habibi, A, Bachir, D, Galacteros, F. The natural history of asymptomatic osteonecrosis of the femoral head in adults with sickle cell disease. J Bone Joint Surg Am. 2006;88:2565–2572.CrossRefGoogle ScholarPubMed
Bishop, AR, Roberson, JR, Eckman, JR, Fleming, LL. Total hip arthroplasty in patients who have sickle-cell hemoglobinopathy. J Bone Joint Surg Am. 1988;70:853–855.CrossRefGoogle ScholarPubMed
Hernigou, P, Zilber, S, Filippini, P, Mathieu, G, Poignard, A, Galacteros, F. Total THA in adult osteonecrosis related to sickle cell disease. Clin Orthop Rel Res. 2008;466:300–308.CrossRefGoogle Scholar
Koshy, M, Entsuah, R, Koranda, A, et al. Leg ulcers in patients with sickle cell disease. Blood. 1989;74:1403–1408.Google ScholarPubMed
Serjeant, GR. Leg ulceration in sickle cell anemia. Arch Intern Med. 1974;133:690–694.CrossRefGoogle ScholarPubMed
Eckman, JR. Leg ulcers in sickle cell disease. Hematol Oncol Clin North Am. 1996;10:1333–1344.CrossRefGoogle ScholarPubMed
Ballas, SK. Pain management of sickle cell disease. Hematol Oncol Clin North Am. 2005;19:785–802.CrossRefGoogle ScholarPubMed
Adams, RJ. Neurologic complications. In: Embury, SH, Hebbel, RP, Mohondas, N, Steinberg, MH, eds. Sickle Cell Disease: Basic Principles and Clinical Practice. 1st ed. New York: Raven Press; 1994:599–621.Google Scholar
Konotey-Ahulu, FI. Mental-nerve neuropathy: a complication of sickle-cell crisis. Lancet. 1972;2:388.CrossRefGoogle ScholarPubMed
Asher, SW. Multiple cranial neuropathies, trigeminal neuralgia, and vascular headaches in sickle cell disease, a possible common mechanism. Neurology. 1980;30:210–211.CrossRefGoogle ScholarPubMed
Sommer, C. Painful neuropathies. Curr Opin Neurol. 2003;16:623–628.CrossRefGoogle ScholarPubMed
Woolf, CJ, Mannion, RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999;353:1959–1964.CrossRefGoogle ScholarPubMed
Harden, RN. Chronic neuropathic pain. Mechanisms, diagnosis, and treatment. Neurologist. 2005;11:111–122.CrossRefGoogle ScholarPubMed
Irving, GA. Contemporary assessment and management of neuropathic pain. Neurology. 2005;64:S21–27.CrossRefGoogle ScholarPubMed
Siddall, PJ, Cousins, MJ. Persistent pain as a disease entity: implications for clinical management. Anesth Analg. 2004;99:510–520.CrossRefGoogle ScholarPubMed
Edwards, RR. Individual differences in endogenous pain modulation as a risk factor for chronic pain. Neurology. 2005;65:437–443.CrossRefGoogle ScholarPubMed
Krantz, MJ, Mehler, PS. Treating opioid dependence. Growing implications for primary care. Arch Intern Med. 2004;164:277–288.CrossRefGoogle ScholarPubMed
Portenoy, RK, Foley, KM. Chronic use of opioid analgesics in non-malignant pain: report of 38 cases. Pain. 1986;25:171–186.CrossRefGoogle ScholarPubMed
Schofferman, J. Long-term use of opioid analgesics for the treatment of chronic pain of nonmalignant origin. J Pain Symptom Manage. 1993;8:279–288.CrossRefGoogle ScholarPubMed
Ballantyne, JC, Mao, J. Opioid therapy for chronic pain. N Engl J Med. 2003;349:1943–1953.CrossRefGoogle ScholarPubMed
Ballantyne, JC. Opioids for chronic pain: taking stock. Pain. 2006;125:3–4.CrossRefGoogle ScholarPubMed
Kalso, E, Edwards, JE, Moore, RA, McQuay, HJ. Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain. 2004;112:372–380.CrossRefGoogle ScholarPubMed
Eriksen, J, Sjogren, P, Bruera, E, Ekholm, O, Rasmussen, NK. Critical issues on opioids in chronic non-cancer pain: an epidemiological study. Pain. 2006;125:172–179.CrossRefGoogle Scholar
Medicine, AAoP, Society, AP. The use of opioids for the treatment of chronic pain: a consensus statement. Clin J Pain. 1997;13:6–8.Google Scholar
Fishman, SM, Wilsey, B, Yang, J, Reisfield, GM, Bandman, TB, Borsook, D. Adherence monitoring and drug surveillance in chronic opioid therapy. J Pain Symptom Manage. 2000;20:293–307.CrossRefGoogle ScholarPubMed
States Federation of Medical Boards, Model policy for the use of controlled substances for the treatment of pain. Available at: http://www.fsmb.org/pdf/2004_grpol_Controlled_Substances.pdf. 2004.
Fishman, SM, Bandman, TB, Edwards, A, Borsook, D. The opioid contract in the management of chronic pain. J Pain Symptom Manage. 1999;18:27–37.CrossRefGoogle ScholarPubMed
Consent for chronic opioid therapy. American Academy of Pain Medicine, 2001. Available at: http://www.painmed.org/pdf/opioid_consent_form.pdf.
,Long-term Controlled Substances Therapy for Chronic Pain. Sample Agreement. 1997 Available at: http://www.painmed.org/pdf/controlled_substances_sample_agrmt.pdf.
Arnold, RM, Han, PK, Seltzer, D. Opioid contracts in chronic nonmalignant pain management: objectives and uncertainties. Am J Med. 2006;119:292–296.CrossRefGoogle ScholarPubMed
Hariharan, J, Lamb, GC, Neuner, JM. Long-term opioid contract use for chronic pain management in primary care practice. A five year experience. J Gen Intern Med. 2007;22:485–490.CrossRefGoogle ScholarPubMed
Zylicz, Z, Twycross, R. Opioid-induced hyperalgesia may be more frequent than previously thought. J Clin Oncol. 2008;26:1564.CrossRefGoogle ScholarPubMed
Doverty, M, White, JM, Somogyi, AA, Bochner, F, Ali, R, Ling, W. Hyperalgesic responses in methadone maintenance patients. Pain. 2001;90:91–96.CrossRefGoogle ScholarPubMed
White, JM. Pleasure into pain: the consequences of long-term opioid use. Addict Behav. 2004;29:1311–1324.CrossRefGoogle ScholarPubMed
Angst, MS, Clark, JD. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006;104:570–587.CrossRefGoogle ScholarPubMed
Chang, G, Chen, L, Mao, J. Opioid tolerance and hyperalgesia. Med Clin North Am. 2007;91:199–211.CrossRefGoogle ScholarPubMed
Mao, J. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy. Pain. 2002;100:213–217.CrossRefGoogle ScholarPubMed
Mao, J. Opioid-induced abnormal pain sensitivity. Curr Pain Headache Rep. 2006;10:67–70.CrossRefGoogle ScholarPubMed
,American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Revised. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
Kalivas, PW, O'Brien, C. Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology. 2008;33:166–180.CrossRefGoogle ScholarPubMed
Brien, CP. Research advances in the understanding and treatment of addiction. Am J Addict. 2003;12 Suppl 2:S36–47.CrossRefGoogle Scholar
Jackson, JL, Kroenke, K. Difficult patient encounters in the ambulatory clinic: clinical predictors and outcomes. Arch Intern Med. 1999;159:1069–1075.CrossRefGoogle ScholarPubMed
Adams, J, Murray, R, 3rd. The general approach to the difficult patient. Emerg Med Clin North Am. 1998;16:689–700.CrossRefGoogle ScholarPubMed
Hull, SK, Broquet, K. How to manage difficult patient encounters. Fam Pract Manage. 2007;14:30–34.Google ScholarPubMed
Krebs, EE, Garrett, JM, Konrad, TR. The difficult doctor? Characteristics of physicians who report frustration with patients: an analysis of survey data. BMC Health Serv Res. 2006;6:128.CrossRefGoogle ScholarPubMed
Koekkoek, B, Meijel, B, Hutschemaekers, G. “Difficult patients” in mental health care: a review. Psychiatr Serv. 2006;57:795–802.CrossRefGoogle ScholarPubMed
Haas, LJ, Leiser, JP, Magill, MK, Sanyer ON. Management of the difficult patient. Am Fam Physician. 2005;72:2063–2068.Google ScholarPubMed
Tandeter, H. Making peace with your “difficult patient.”Patient Educ Couns. 2006;62:3–4.CrossRefGoogle ScholarPubMed
Elder, N, Ricer, R, Tobias, B. How respected family physicians manage difficult patient encounters. J Am Board Fam Med. 2006;19:533–541.CrossRefGoogle ScholarPubMed
Marks, RM, Sachar, EJ. Undertreatment of medical inpatients with narcotic analgesics. Ann Intern Med. 1973;78:173–181.CrossRefGoogle ScholarPubMed
Marlowe, KF, Chicella, MF. Treatment of sickle cell pain. Pharmacotherapy. 2002;22:484–491.CrossRefGoogle ScholarPubMed
Sutton, M, Atweh, GF, Cashman, TD, Davis, WT. Resolving conflicts: misconceptions and myths in the care of the patient with sickle cell disease. Mt Sinai J Med. 1999;66:282–285.Google ScholarPubMed
Platt, OS. Hydroxyurea for the treatment of sickle cell anemia. N Engl J Med. 2008;358:1362–1369.CrossRefGoogle ScholarPubMed
Eccleston, C, Yorke, L, Morley, S, Williams, AC, Mastroyannopoulou, K. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2003:CD003968.CrossRefGoogle ScholarPubMed
Anie, KA, Green, J. Psychological therapies for sickle cell disease and pain. Cochrane Database Syst Rev. 2002:CD001916.CrossRefGoogle ScholarPubMed
Ballas, SK. Sickle cell disease: current clinical management. Semin Hematol. 2001;38:307–314.CrossRefGoogle ScholarPubMed

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