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Chapter 3 - Necrosis, Stromal Changes and Artefacts

Published online by Cambridge University Press:  12 November 2020

Jon van der Walt ,
Attilio Orazi  and
Daniel A. Arber
By
Konnie Hebeda
Jon van der Walt
Affiliation:
St Thomas’ Hospital, London
Attilio Orazi
Affiliation:
Texas Tech University
Daniel A. Arber
Affiliation:
University of Chicago
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Summary

The bone marrow (BM) extracellular matrix (ECM) is often inconspicuous, and hence neglected in a normal BM trephine biopsy (BMB), but it has essential functions in the homeostasis of bone and the maturation of haematopoiesis (see Chapter 2). The ECM surrounds the bony trabeculae, which are covered by osteoblasts and osteoclasts, the latter an essential component of the stem cell niche, and embeds the maturing haematopoietic cells. It is rich in hyaluronic acid, type III collagen (reticulin), fibronectin and laminin.

Keywords

Necrosisstromaartefactsedemahemorrhageatrophyamyloidmyelofibrosis
Type
Chapter
Information
Diagnostic Bone Marrow Haematopathology , pp. 26 - 41
Publisher: Cambridge University Press
Print publication year: 2021

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