Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The developmental origins of health and disease: an overview
- 2 The ‘developmental origins’ hypothesis: epidemiology
- 3 The conceptual basis for the developmental origins of health and disease
- 4 The periconceptional and embryonic period
- 5 Epigenetic mechanisms
- 6 A mitochondrial component of developmental programming
- 7 Role of exposure to environmental chemicals in developmental origins of health and disease
- 8 Maternal nutrition and fetal growth and development
- 9 Placental mechanisms and developmental origins of health and disease
- 10 Control of fetal metabolism: relevance to developmental origins of health and disease
- 11 Lipid metabolism: relevance to developmental origins of health and disease
- 12 Prenatal hypoxia: relevance to developmental origins of health and disease
- 13 The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease
- 14 Perinatal influences on the endocrine and metabolic axes during childhood
- 15 Patterns of growth: relevance to developmental origins of health and disease
- 16 The developmental environment and the endocrine pancreas
- 17 The developmental environment and insulin resistance
- 18 The developmental environment and the development of obesity
- 19 The developmental environment and its role in the metabolic syndrome
- 20 Programming the cardiovascular system
- 21 The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies
- 22 The developmental environment and atherogenesis
- 23 The developmental environment, renal function and disease
- 24 The developmental environment: effect on fluid and electrolyte homeostasis
- 25 The developmental environment: effects on lung structure and function
- 26 Developmental origins of asthma and related allergic disorders
- 27 The developmental environment: influences on subsequent cognitive function and behaviour
- 28 The developmental environment and the origins of neurological disorders
- 29 The developmental environment: clinical perspectives on effects on the musculoskeletal system
- 30 The developmental environment: experimental perspectives on skeletal development
- 31 The developmental environment and the early origins of cancer
- 32 The developmental environment: implications for ageing and life span
- 33 Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease
- 34 Developmental origins of health and disease: public-health perspectives
- 35 Developmental origins of health and disease: implications for developing countries
- 36 Developmental origins of health and disease: ethical and social considerations
- 37 Past obstacles and future promise
- Index
- References
1 - The developmental origins of health and disease: an overview
Published online by Cambridge University Press: 08 August 2009
Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The developmental origins of health and disease: an overview
- 2 The ‘developmental origins’ hypothesis: epidemiology
- 3 The conceptual basis for the developmental origins of health and disease
- 4 The periconceptional and embryonic period
- 5 Epigenetic mechanisms
- 6 A mitochondrial component of developmental programming
- 7 Role of exposure to environmental chemicals in developmental origins of health and disease
- 8 Maternal nutrition and fetal growth and development
- 9 Placental mechanisms and developmental origins of health and disease
- 10 Control of fetal metabolism: relevance to developmental origins of health and disease
- 11 Lipid metabolism: relevance to developmental origins of health and disease
- 12 Prenatal hypoxia: relevance to developmental origins of health and disease
- 13 The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease
- 14 Perinatal influences on the endocrine and metabolic axes during childhood
- 15 Patterns of growth: relevance to developmental origins of health and disease
- 16 The developmental environment and the endocrine pancreas
- 17 The developmental environment and insulin resistance
- 18 The developmental environment and the development of obesity
- 19 The developmental environment and its role in the metabolic syndrome
- 20 Programming the cardiovascular system
- 21 The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies
- 22 The developmental environment and atherogenesis
- 23 The developmental environment, renal function and disease
- 24 The developmental environment: effect on fluid and electrolyte homeostasis
- 25 The developmental environment: effects on lung structure and function
- 26 Developmental origins of asthma and related allergic disorders
- 27 The developmental environment: influences on subsequent cognitive function and behaviour
- 28 The developmental environment and the origins of neurological disorders
- 29 The developmental environment: clinical perspectives on effects on the musculoskeletal system
- 30 The developmental environment: experimental perspectives on skeletal development
- 31 The developmental environment and the early origins of cancer
- 32 The developmental environment: implications for ageing and life span
- 33 Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease
- 34 Developmental origins of health and disease: public-health perspectives
- 35 Developmental origins of health and disease: implications for developing countries
- 36 Developmental origins of health and disease: ethical and social considerations
- 37 Past obstacles and future promise
- Index
- References
Summary
The concept of developmental origins of health and disease (DOHaD) grew from the earlier concept of fetal origins of adult disease (FOAD) (reviewed in Barker 1995, 1998). There are two important reasons for the change. The first results from the large amount of research (much of it reviewed in this book) showing that the early life events which determine in part the risk of later disease occur not only in the fetal period specifically, but throughout the plastic phase of development. In this respect the use of the word ‘development’ is helpful because it implies not only effects operating during early stages of embryonic life (usually the preserve of developmental biology) but also those in infancy. Secondly, the DOHaD terminology emphasises that this area of science has implications not only for disease, and its prevention, but also for health promotion. The latter is of great importance in public health and education programmes in many parts of the world. But the accent on ‘developmental origins’ is more than just a flag of convenience under which several disciplines may sail: it represents a fundamental shift in thinking about the way in which early life processes affect later health and disease in humans.
Previously, proponents of FOAD championed the view that prenatal events were of utmost importance.
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- Information
- Developmental Origins of Health and Disease , pp. 1 - 5Publisher: Cambridge University PressPrint publication year: 2006
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