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31 - The developmental environment and the early origins of cancer

Published online by Cambridge University Press:  08 August 2009

By
Anders Ekbom
Edited by
Peter Gluckman  and
Mark Hanson
Anders Ekbom
Affiliation:
Karolinska University Hospital
Peter Gluckman
Affiliation:
University of Auckland
Mark Hanson
Affiliation:
University of Southampton
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Summary

Introduction

The hypothesis that the intrauterine environment is of importance to the aetiology of certain forms of cancer is not new. Studies of children exposed in utero to radiation in Japan at the end of the Second World War indicate a special vulnerability during the perinatal period for future cancer risks (Kato et al. 1989). Although the increased risk was most pronounced for haematopoietic cancers, an excess number of breast cancers has also been demonstrated. Similarly, strong associations have been shown between exposure to diethylstilbestrol (DES) given to expectant mothers during pregnancy and vaginal adenocarcinoma in young women (Greenwald et al. 1971). These two examples are of major importance as they show that there is a window of vulnerability already ‘open’ in utero.

Although the findings mentioned above prove that there are biological pathways which can act in a cancerogenic process at an early stage in life, the two exposures (DES and radiation on a level with Hiroshima and Nagasaki) are extremely rare. However, in the case of haematopoietic cancers, especially leukaemia in childhood, studies have shown that chromosomal translocations are already present at birth in children that later will manifest with leukaemia (Hjalgrim et al. 2002), indicating that factors other than those mentioned above are of importance in utero. However, in order to study other cancers that will occur in adult life, researchers are facing a formidable challenge. What sort of exposures are we interested in?

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Developmental Origins of Health and Disease , pp. 415 - 425
Publisher: Cambridge University Press
Print publication year: 2006

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References

Adami, H. O., Bergstrom, R., Mohner, M.et al. (1994). Testicular cancer in nine northern European countries. Int. J. Cancer, 59, 33–8.CrossRefGoogle ScholarPubMed
Adami, H. O., Persson, I., Ekbom, A.et al. (1995). The aetiology and pathogenesis of human breast cancer. Mutat. Res., 333, 29–35.CrossRefGoogle ScholarPubMed
Ahlgren, M., Sorensen, T., Wohlfahrt, J.et al. (2003). birthweight and risk of breast cancer in a cohort of 106,504 women. Int. J. Cancer, 107, 997–1000.CrossRefGoogle Scholar
Akre, O., Ekbom, A., Hsieh, C. C., Trichopoulos, D. and Adami, H. O. (1996). Testicular nonseminoma and seminoma in relation to perinatal characteristics. J. Natl. Cancer. Inst., 88, 883–9.CrossRefGoogle ScholarPubMed
Bergstrom, R., Adami, H. O., Mohner, M.et al. (1996). Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J. Natl. Cancer. Inst., 88, 727–33.CrossRefGoogle ScholarPubMed
Boisen, K. A., Main, K. M., Rajpert-De Meyts, E. and Skakkebaek, N. E. (2001). Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann. NY Acad. Sci., 948, 90–9.CrossRefGoogle ScholarPubMed
Boland, L. L., Mink, P. J., Bushhouse, S. A. and Folsom, A. R. (2003). Weight and length at birth and risk of early-onset prostate cancer (United States). Cancer Causes Control, 14, 335–8.CrossRefGoogle Scholar
Braun, M. M., Ahlbom, A., Floderus, B., Brinton, L. A. and Hoover, R. N. (1995). Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control, 6, 519–24.CrossRefGoogle Scholar
Brinton, L. A., Lubin, J. H., Burich, M. C.et al. (2000). Breast cancer following augmentation mammoplasty (United States). Cancer Causes Control, 11, 819–27.CrossRefGoogle Scholar
Brinton, L. A., Persson, I., Boice, J. D., McLaughlin, J. K. and Fraumeni, J. F. (2001). Breast cancer risk in relation to amount of tissue removed during breast reduction operations in Sweden. Cancer, 91, 478–83.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Brown, L. M.Pottern, L. M. and Hoover, R. N. (1986). Prenatal and perinatal risk factors for testicular cancer. Cancer Res., 46, 4812–16.Google ScholarPubMed
Byrne, C., Schairer, C., Brinton, L. A. (2001). Effects of mammographic density and benign breast disease on breast cancer risk (United States). Cancer Causes Control, 12, 103–10.CrossRefGoogle Scholar
Depue, R. H., Pike, M. C. and Henderson, B. E. (1983). Estrogen exposure during gestation and risk of testicular cancer. J. Natl. Cancer Inst., 71, 1151–5.Google ScholarPubMed
Eby, N., Chang-Claude, J. and Bishop, D. T. (1994). Familial risk and genetic susceptibility for breast cancer. Cancer Causes Control, 5, 458–70.CrossRefGoogle ScholarPubMed
Ekbom, A., Trichopoulos, D., Adami, H. O., Hsieh, C. C. and Lan, S. J. (1992). Evidence of prenatal influences on breast cancer risk. Lancet, 340, 1015–18.CrossRefGoogle ScholarPubMed
Ekbom, A., Adami, H. O., Trichopoulos, D. (1994). Epidemiologic correlates of breast cancer laterality (Sweden). Cancer Causes Control, 5, 510–16.CrossRefGoogle Scholar
Ekbom, A., Thurfjell, E., Hsieh, C. C., Trichopoulos, D. and Adami, H. O. (1995). Perinatal characteristics and adult mammographic patterns. Int. J. Cancer, 61, 177–80.CrossRefGoogle ScholarPubMed
Ekbom, A., Hsieh, C. C., Lipworth, L.et al. (1996a). Perinatal characteristics in relation to incidence of and mortality from prostate cancer. BMJ, 313, 337–41.CrossRefGoogle Scholar
Ekbom, A., Wicklund-Glynn, A. and Adami, H. O. (1996b). DDT and testicular cancer. Lancet, 347, 553–4.CrossRefGoogle Scholar
Ekbom, A., Hsieh, C. C., Lipworth, L., Adami, H. O. and Trichopoulos, D. (1997). Intrauterine environment and breast cancer risk in women: a population-based study. J. Natl. Cancer Inst., 89, 71–6.CrossRefGoogle ScholarPubMed
Ekbom, A., Erlandsson, G., Hsieh, C.et al. (2000a). Risk of breast cancer in prematurely born women. J. Natl. Cancer Inst., 92, 840–1.CrossRefGoogle Scholar
Ekbom, A., Wuu, J., Adami, H. O.et al. (2000b). Duration of gestation and prostate cancer risk in offspring. Cancer Epidemiol. Biomarkers Prev., 9, 221–3.Google Scholar
Ekbom, A., Richiardi, L., Akre, O., Montgomery, S. M. and Sparen, P. (2003). Age at immigration and duration of stay in relation to risk for testicular cancer among Finnish immigrants in Sweden. J. Natl. Cancer Inst., 95, 1238–40.CrossRefGoogle ScholarPubMed
Fossa, S. D. and Kravdal, O. (2000). Fertility in Norwegian testicular cancer patients. Br. J. Cancer, 82, 737–41.CrossRefGoogle ScholarPubMed
Garoff, L. and Seppala, M. (1976). Toxemia of pregnancy: assessment of fetal distress by urinary estriol and circulating human placental lactogen and alpha-fetoprotein levels. Am. J. Obstet. Gynecol., 126, 1027–33.CrossRefGoogle ScholarPubMed
Garson, A., Bricker, J. T. and McNamara, D. G., eds. (1990). The Science and Practice of Pediatric Cardiology. Philadelphia, PA: Lea and Febiger.Google Scholar
Genuth, S. M. (1983). The reproductive glands. In Physiology (ed. Levy, M. N.). St Louis, MO: Mosby, pp. 1069–115.
Greenwald, P., Barlow, J. J., Nasca, P. C. and Burnett, W. S. (1971). Vaginal cancer after maternal treatment with synthetic oestrogen. N. Engl. J. Med., 285, 390–2.CrossRefGoogle Scholar
Haenszel, W. and Kurihara, M. (1968). Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J. Natl. Cancer Inst., 40, 43–68.Google ScholarPubMed
Haughey, B. P., Graham, S., Brasure, J.et al. (1989). The epidemiology of testicular cancer in upstate New York. Am. J. Epidemiol., 130, 25–36.CrossRefGoogle ScholarPubMed
Henderson, B. E., Benton, B., Jing, J., Yu, M.C. and Pike, M. C. (1979). Risk factors for cancer of the testis in young men. Int. J. Cancer, 23, 598–602.CrossRefGoogle ScholarPubMed
Henderson, B. E., Ross, R. K., Yu, M. C. and Bernstein, L. (1997). An explanation for the increasing incidence of testis cancer: decreasing age at first full-term pregnancy. J. Natl. Cancer Inst., 89, 818–20.CrossRefGoogle ScholarPubMed
Hilakivi-Clarke, L., Clarke, R., Onojafe, I.et al. (1997). A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring. Proc. Natl. Acad. Sci. USA, 94, 9372–7.CrossRefGoogle ScholarPubMed
Hjalgrim, L. L., Madsen, H. O., Melbye, M.et al. (2002). Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br. J. Cancer, 87, 994–9.CrossRefGoogle ScholarPubMed
Hubinette, A., Cnattingius, S., Ekbom, A.et al. (2001). Birthweight, early environment, and genetics: a study of twins discordant for acute myocardial infarction. Lancet, 357, 1997–2001.CrossRefGoogle ScholarPubMed
Innes, K., Byers, T. and Schymura, M.et al. (2000). Birth characteristics and subsequent risk for breast cancer in very young women. Am. J. Epidemiol., 152, 1121–8.CrossRefGoogle ScholarPubMed
Jacobsen, R., Bostofte, E., Engholm, G.et al. (2000). Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ, 321, 789–92.CrossRefGoogle ScholarPubMed
Kaijser, M., Granath, F., Jacobsen, G., Cnattingius, S. and Ekbom, A. (2000). Maternal pregnancy estriol levels in relation to anamnestic and fetal anthropometric data. Epidemiology, 11, 315–19.CrossRefGoogle ScholarPubMed
Kaijser, M., Lichtenstein, P., Granath, F.et al. (2001). in utero exposures and breast cancer: a study of opposite-sexed twins. J. Natl. Cancer Inst., 93, 60–2.CrossRefGoogle ScholarPubMed
Kaijser, M., Jacobsen, G., Granath, F., Cnattingius, S. and Ekbom, A. (2002). Maternal age, anthropometrics and pregnancy oestriol. Paediatr. Perinat. Epidemiol., 16, 149–53.CrossRefGoogle ScholarPubMed
Kaijser, M., Akre, O., Cnattingius, S. and Ekbom, A. (2003a). Preterm birth, birthweight, and subsequent risk of female breast cancer. Br. J. Cancer, 89, 1664–6.CrossRefGoogle Scholar
Kaijser, M., Akre, O., Cnattingius, S. and Ekbom, A. (2003b). Maternal lung cancer and testicular cancer risk in the offspring. Cancer Epidemiol. Biomarkers Prev., 12, 643–6.Google Scholar
Kappel, B., Hansen, K., Moller, J. and Faaborg-Andersen, J. (1985). Human placental lactogen and dU-oestrogen levels in normal twin pregnancies. Acta Genet. Med. Gemellol. (Roma), 34, 59–65.CrossRefGoogle ScholarPubMed
Kato, H., Yoshimoto, Y. and Schull, W. J. (1989). Risk of cancer among children exposed to atomic bomb radiation in utero: a review. IARC Sci. Publ., 96, 365–74.Google Scholar
Levi, F., Te, V. C. and Vecchia, C. (1990). Testicular cancer trends in the Canton of Vaud, Switzerland, 1974–1987. Br. J. Cancer, 62, 871–3.CrossRefGoogle Scholar
Long, P. A., Abell, D. A. and Beischer, N. A. (1979). Fetal growth and placental function assessed by urinary estriol excretion before the onset of pre-eclampsia. Am. J. Obstet. Gynecol., 135, 344–7.CrossRefGoogle ScholarPubMed
McCormack, V. A., Santos Silva, dos I., Stavola, B. L.et al. (2003). Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ, 326, 248.CrossRefGoogle ScholarPubMed
Mellemkjaer, L., Olsen, M. L., Sorensen, H. T.et al. (2003). Birthweight and risk of early-onset breast cancer (Denmark). Cancer Causes Control, 14, 61–4.CrossRefGoogle Scholar
Michels, K. B., Trichopoulos, D., Robins, J. M.et al. (1996). Birthweight as a risk factor for breast cancer. Lancet, 348, 1542–6.CrossRefGoogle ScholarPubMed
Moller, H. (1989). Decreased testicular cancer risk in men born in wartime. J. Natl. Cancer Inst., 81, 1668–9.CrossRefGoogle ScholarPubMed
Moss, A. R., Osmond, D., Bacchetti, P., Torti, F. M. and Gurgin, V.et al. (1986). Hormonal risk factors in testicular cancer: a case-control study. Am. J. Epidemiol, 124, 39–52.CrossRefGoogle ScholarPubMed
Nylander, P. P. S. (1983). The phenomenon of twinning. In Obstetrical Epidemiology (ed. Thomson, A. M.). London: Academic Press, pp. 143–65.Google Scholar
Okasha, M., McCarron, P., Gunnell, D. and Davey Smith, G. (2003). Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res. Treat., 78, 223–76.CrossRefGoogle ScholarPubMed
Palmer, J. R., Hatch, E. E., Rosenberg, C. L.et al. (2002). Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States). Cancer Causes Control, 13, 753–8.CrossRefGoogle Scholar
Parkin, D. M., Muir, C. S. and Whelan, S. L. (1992). Cancer Incidence in Five Continents, vol 6. Lyon: IARC.Google ScholarPubMed
Pearce, N., Sheppard, R. A., Howard, J. K., Fraser, J. and Lilley, B. M. (1987). Time trends and occupational differences in cancer of the testis in New Zealand. Cancer, 59, 1677–82.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Pettersson, A., Kaijser, M., Richiardi, L. et al. (2004). Women smoking and testicular cancer: one epidemic causing another?Int. J. Cancer, 109, 941–4.CrossRefGoogle Scholar
Pinczowski, D., McLaughlin, J. K., Lackgren, G., Adami, H. O. and Persson, I. (1991). Occurrence of testicular cancer in patients operated on for cryptorchidism and inguinal hernia. J. Urol., 146, 1291–4.CrossRefGoogle ScholarPubMed
Platz, E. A., Giovannucci, E., Rimm, E. B.et al. (1998). Retrospective analysis of birthweight and prostate cancer in the Health Professionals Follow-up Study. Am. J. Epidemiol., 147, 1140–4.CrossRefGoogle ScholarPubMed
Potosky, A. L., Kessler, L., Gridley, G., Brown, C. C. and Horm, J. W. (1990). Rise in prostatic cancer incidence associated with increased use of transurethral resection. J. Natl. Cancer Inst., 82, 1624–8.CrossRefGoogle ScholarPubMed
Prener, A., Hsieh, C. C., Engholm, G., Trichopoulos, D. and Jensen, O. M. (1992). Birth order and risk of testicular cancer. Cancer Causes Control., 3, 265–72.CrossRefGoogle ScholarPubMed
Prins, G. S. and Birch, L. (1997). Neonatal oestrogen exposure up-regulates oestrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology, 138, 1801–9.CrossRefGoogle ScholarPubMed
Richiardi, L., Akre, O., Bellocco, R. and Ekbom, A. (2002). Perinatal determinants of germ-cell testicular cancer in relation to histological subtypes. Br. J. Cancer, 87, 545–50.CrossRefGoogle ScholarPubMed
Richiardi, L., Akre, O., Montgomery, S. M.et al. (2004a). Fecundity and twinning rates as measures of fertility before diagnosis of germ-cell testicular cancer. J. Natl. Cancer Inst., 96, 145–7.CrossRefGoogle Scholar
Richiardi, L., Akre, O., Lambe, M.et al. (2004b). Birth order, sibship size, and risk for germ-cell testicular cancer. Epidemiology, 15, 323–9.CrossRefGoogle Scholar
Robine, N., Relier, J. P. and Le Bars, S. (1988). Urocytogram, an index of maturity in premature infants. Biol. Neonate, 54, 93–9.CrossRefGoogle ScholarPubMed
Ros, H. S., Lichtenstein, P., Exbom, A. and Cnattingius, S. (2001). Tall or short? Twenty years after pre-eclampsia exposure in utero: comparisons of final height, body mass index, waist-to-hip ratio, and age at menarche among women, exposed and unexposed to pre-eclampsia during fetal life. Pediatr. Res., 49, 763–9.CrossRefGoogle ScholarPubMed
Ross, R. K. and Henderson, B. E. (1994). Do diet and androgens alter prostate cancer risk via a common etiologic pathway?J. Natl. Cancer Inst., 86, 252–4.CrossRefGoogle Scholar
Sanderson, M., Williams, M. A., Malone, K. E.et al. (1996). Perinatal factors and risk of breast cancer. Epidemiology, 7, 34–7.CrossRefGoogle ScholarPubMed
Sanderson, M., Shu, X. O., Jin, F.et al. (2002). Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population. Br. J. Cancer, 86, 84–8.CrossRefGoogle Scholar
Schottenfeld, D., Warshauer, M. E., Sherlock, S.et al. (1980). The epidemiology of testicular cancer in young adults. Am. J. Epidemiol., 112, 232–46.CrossRefGoogle ScholarPubMed
Sedin, G., Bergquist, C. and Lindgern, P. G.et al. (1985). Ovarian hyperstimulation syndrome in preterm infants. Pediatr. Res., 19, 548–52.CrossRefGoogle ScholarPubMed
Service, R. F. (1998). New role for oestrogen in cancer?Science, 279, 1631–3.CrossRefGoogle Scholar
Sharpe, R. M. (1995). Reproductive biology: another DDT connection. Nature, 375, 538–9.CrossRefGoogle ScholarPubMed
Sharpe, R. M. and Skakkebaek, N. E. (1993). Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?Lancet, 341, 1392–5.CrossRefGoogle ScholarPubMed
Swerdlow, A. J., Huttly, S. R. and Smith, P. G.et al. (1987). Prenatal and familial associations of testicular cancer. Br. J. Cancer, 55, 571–7.CrossRefGoogle ScholarPubMed
Tibblin, G., Eriksson, M., Cnattingius, S. and Ekbom, A. (1995). High birthweight as a predictor of prostate cancer risk. Epidemiology, 6, 423–4.CrossRefGoogle ScholarPubMed
Titus-Ernstoff, L., Egan, K. M., Newcomb, P. A.et al. (2002). Early life factors in relation to breast cancer risk in postmenopausal women. Cancer Epidemiol. Biomarkers Prev., 11, 207–10.Google ScholarPubMed
Trichopoulos, D. (1990). Is breast cancer initiated in utero?Epidemiology, 1, 95–6.Google ScholarPubMed
Trichopoulos, D. and Lipman, R. D. (1992). Mammary gland mass and breast cancer risk. Epidemiology, 3, 523–6.CrossRefGoogle ScholarPubMed
Wanderas, E. H., Tretli, S. and Fossa, S. D. (1995). Trends in incidence of testicular cancer in Norway 1955–1992. Eur. J. Cancer, 31A, 2044–8.CrossRefGoogle ScholarPubMed
Wanderas, E. H., Grotmol, T., Fossa, S. D. and Tretli, S. (1998). Maternal health and pre- and perinatal characteristics in the etiology of testicular cancer: a prospective population- and register-based study on Norwegian males born between 1967 and 1995. Cancer Causes Control, 9, 475–86.CrossRefGoogle ScholarPubMed
Vatten, L. J., Maehle, B. O., Lund Nilsen, T. I.et al. (2002). birthweight as a predictor of breast cancer: a case–control study in Norway. Br. J. Cancer, 86, 89–91.CrossRefGoogle ScholarPubMed
Yuen, J., Ekbom, A., Trichopoulos, D., Hsieh, C. C. and Adami, H. O. (1994). Season of birth and breast cancer risk in Sweden. Br. J. Cancer, 70, 564–8.CrossRefGoogle ScholarPubMed

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