Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The developmental origins of health and disease: an overview
- 2 The ‘developmental origins’ hypothesis: epidemiology
- 3 The conceptual basis for the developmental origins of health and disease
- 4 The periconceptional and embryonic period
- 5 Epigenetic mechanisms
- 6 A mitochondrial component of developmental programming
- 7 Role of exposure to environmental chemicals in developmental origins of health and disease
- 8 Maternal nutrition and fetal growth and development
- 9 Placental mechanisms and developmental origins of health and disease
- 10 Control of fetal metabolism: relevance to developmental origins of health and disease
- 11 Lipid metabolism: relevance to developmental origins of health and disease
- 12 Prenatal hypoxia: relevance to developmental origins of health and disease
- 13 The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease
- 14 Perinatal influences on the endocrine and metabolic axes during childhood
- 15 Patterns of growth: relevance to developmental origins of health and disease
- 16 The developmental environment and the endocrine pancreas
- 17 The developmental environment and insulin resistance
- 18 The developmental environment and the development of obesity
- 19 The developmental environment and its role in the metabolic syndrome
- 20 Programming the cardiovascular system
- 21 The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies
- 22 The developmental environment and atherogenesis
- 23 The developmental environment, renal function and disease
- 24 The developmental environment: effect on fluid and electrolyte homeostasis
- 25 The developmental environment: effects on lung structure and function
- 26 Developmental origins of asthma and related allergic disorders
- 27 The developmental environment: influences on subsequent cognitive function and behaviour
- 28 The developmental environment and the origins of neurological disorders
- 29 The developmental environment: clinical perspectives on effects on the musculoskeletal system
- 30 The developmental environment: experimental perspectives on skeletal development
- 31 The developmental environment and the early origins of cancer
- 32 The developmental environment: implications for ageing and life span
- 33 Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease
- 34 Developmental origins of health and disease: public-health perspectives
- 35 Developmental origins of health and disease: implications for developing countries
- 36 Developmental origins of health and disease: ethical and social considerations
- 37 Past obstacles and future promise
- Index
- References
31 - The developmental environment and the early origins of cancer
Published online by Cambridge University Press: 08 August 2009
By
Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 The developmental origins of health and disease: an overview
- 2 The ‘developmental origins’ hypothesis: epidemiology
- 3 The conceptual basis for the developmental origins of health and disease
- 4 The periconceptional and embryonic period
- 5 Epigenetic mechanisms
- 6 A mitochondrial component of developmental programming
- 7 Role of exposure to environmental chemicals in developmental origins of health and disease
- 8 Maternal nutrition and fetal growth and development
- 9 Placental mechanisms and developmental origins of health and disease
- 10 Control of fetal metabolism: relevance to developmental origins of health and disease
- 11 Lipid metabolism: relevance to developmental origins of health and disease
- 12 Prenatal hypoxia: relevance to developmental origins of health and disease
- 13 The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease
- 14 Perinatal influences on the endocrine and metabolic axes during childhood
- 15 Patterns of growth: relevance to developmental origins of health and disease
- 16 The developmental environment and the endocrine pancreas
- 17 The developmental environment and insulin resistance
- 18 The developmental environment and the development of obesity
- 19 The developmental environment and its role in the metabolic syndrome
- 20 Programming the cardiovascular system
- 21 The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies
- 22 The developmental environment and atherogenesis
- 23 The developmental environment, renal function and disease
- 24 The developmental environment: effect on fluid and electrolyte homeostasis
- 25 The developmental environment: effects on lung structure and function
- 26 Developmental origins of asthma and related allergic disorders
- 27 The developmental environment: influences on subsequent cognitive function and behaviour
- 28 The developmental environment and the origins of neurological disorders
- 29 The developmental environment: clinical perspectives on effects on the musculoskeletal system
- 30 The developmental environment: experimental perspectives on skeletal development
- 31 The developmental environment and the early origins of cancer
- 32 The developmental environment: implications for ageing and life span
- 33 Developmental origins of health and disease: implications for primary intervention for cardiovascular and metabolic disease
- 34 Developmental origins of health and disease: public-health perspectives
- 35 Developmental origins of health and disease: implications for developing countries
- 36 Developmental origins of health and disease: ethical and social considerations
- 37 Past obstacles and future promise
- Index
- References
Summary
Introduction
The hypothesis that the intrauterine environment is of importance to the aetiology of certain forms of cancer is not new. Studies of children exposed in utero to radiation in Japan at the end of the Second World War indicate a special vulnerability during the perinatal period for future cancer risks (Kato et al. 1989). Although the increased risk was most pronounced for haematopoietic cancers, an excess number of breast cancers has also been demonstrated. Similarly, strong associations have been shown between exposure to diethylstilbestrol (DES) given to expectant mothers during pregnancy and vaginal adenocarcinoma in young women (Greenwald et al. 1971). These two examples are of major importance as they show that there is a window of vulnerability already ‘open’ in utero.
Although the findings mentioned above prove that there are biological pathways which can act in a cancerogenic process at an early stage in life, the two exposures (DES and radiation on a level with Hiroshima and Nagasaki) are extremely rare. However, in the case of haematopoietic cancers, especially leukaemia in childhood, studies have shown that chromosomal translocations are already present at birth in children that later will manifest with leukaemia (Hjalgrim et al. 2002), indicating that factors other than those mentioned above are of importance in utero. However, in order to study other cancers that will occur in adult life, researchers are facing a formidable challenge. What sort of exposures are we interested in?
- Type
- Chapter
- Information
- Developmental Origins of Health and Disease , pp. 415 - 425Publisher: Cambridge University PressPrint publication year: 2006
References
, , et al. (1994). Testicular cancer in nine northern European countries. Int. J. Cancer, 59, 33–8.CrossRefGoogle ScholarPubMed
, , et al. (1995). The aetiology and pathogenesis of human breast cancer. Mutat. Res., 333, 29–35.CrossRefGoogle ScholarPubMed
, , et al. (2003). birthweight and risk of breast cancer in a cohort of 106,504 women. Int. J. Cancer, 107, 997–1000.CrossRefGoogle Scholar
, , , and (1996). Testicular nonseminoma and seminoma in relation to perinatal characteristics. J. Natl. Cancer. Inst., 88, 883–9.CrossRefGoogle ScholarPubMed
, , et al. (1996). Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J. Natl. Cancer. Inst., 88, 727–33.CrossRefGoogle ScholarPubMed
, , and (2001). Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann. NY Acad. Sci., 948, 90–9.CrossRefGoogle ScholarPubMed
, , and (2003). Weight and length at birth and risk of early-onset prostate cancer (United States). Cancer Causes Control, 14, 335–8.CrossRefGoogle Scholar
, , , and (1995). Effect of twinship on incidence of cancer of the testis, breast, and other sites (Sweden). Cancer Causes Control, 6, 519–24.CrossRefGoogle Scholar
, , et al. (2000). Breast cancer following augmentation mammoplasty (United States). Cancer Causes Control, 11, 819–27.CrossRefGoogle Scholar
, , ., and (2001). Breast cancer risk in relation to amount of tissue removed during breast reduction operations in Sweden. Cancer, 91, 478–83.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
and (1986). Prenatal and perinatal risk factors for testicular cancer. Cancer Res., 46, 4812–16.Google ScholarPubMed
, , (2001). Effects of mammographic density and benign breast disease on breast cancer risk (United States). Cancer Causes Control, 12, 103–10.CrossRefGoogle Scholar
, and (1983). Estrogen exposure during gestation and risk of testicular cancer. J. Natl. Cancer Inst., 71, 1151–5.Google ScholarPubMed
, and (1994). Familial risk and genetic susceptibility for breast cancer. Cancer Causes Control, 5, 458–70.CrossRefGoogle ScholarPubMed
, , , and (1992). Evidence of prenatal influences on breast cancer risk. Lancet, 340, 1015–18.CrossRefGoogle ScholarPubMed
, , (1994). Epidemiologic correlates of breast cancer laterality (Sweden). Cancer Causes Control, 5, 510–16.CrossRefGoogle Scholar
, , , and (1995). Perinatal characteristics and adult mammographic patterns. Int. J. Cancer, 61, 177–80.CrossRefGoogle ScholarPubMed
, , et al. (1996a). Perinatal characteristics in relation to incidence of and mortality from prostate cancer. BMJ, 313, 337–41.CrossRefGoogle Scholar
, , , and (1997). Intrauterine environment and breast cancer risk in women: a population-based study. J. Natl. Cancer Inst., 89, 71–6.CrossRefGoogle ScholarPubMed
, , et al. (2000a). Risk of breast cancer in prematurely born women. J. Natl. Cancer Inst., 92, 840–1.CrossRefGoogle Scholar
, , et al. (2000b). Duration of gestation and prostate cancer risk in offspring. Cancer Epidemiol. Biomarkers Prev., 9, 221–3.Google Scholar
, , , and (2003). Age at immigration and duration of stay in relation to risk for testicular cancer among Finnish immigrants in Sweden. J. Natl. Cancer Inst., 95, 1238–40.CrossRefGoogle ScholarPubMed
and (2000). Fertility in Norwegian testicular cancer patients. Br. J. Cancer, 82, 737–41.CrossRefGoogle ScholarPubMed
and (1976). Toxemia of pregnancy: assessment of fetal distress by urinary estriol and circulating human placental lactogen and alpha-fetoprotein levels. Am. J. Obstet. Gynecol., 126, 1027–33.CrossRefGoogle ScholarPubMed
, and , eds. (1990). The Science and Practice of Pediatric Cardiology. Philadelphia, PA: Lea and Febiger.Google Scholar
Genuth, S. M. (1983). The reproductive glands. In Physiology (ed. ). St Louis, MO: Mosby, pp. 1069–115.
, , and (1971). Vaginal cancer after maternal treatment with synthetic oestrogen. N. Engl. J. Med., 285, 390–2.CrossRefGoogle Scholar
and (1968). Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J. Natl. Cancer Inst., 40, 43–68.Google ScholarPubMed
, , et al. (1989). The epidemiology of testicular cancer in upstate New York. Am. J. Epidemiol., 130, 25–36.CrossRefGoogle ScholarPubMed
, , , . and (1979). Risk factors for cancer of the testis in young men. Int. J. Cancer, 23, 598–602.CrossRefGoogle ScholarPubMed
, , and (1997). An explanation for the increasing incidence of testis cancer: decreasing age at first full-term pregnancy. J. Natl. Cancer Inst., 89, 818–20.CrossRefGoogle ScholarPubMed
, , et al. (1997). A maternal diet high in n-6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring. Proc. Natl. Acad. Sci. USA, 94, 9372–7.CrossRefGoogle ScholarPubMed
, , et al. (2002). Presence of clone-specific markers at birth in children with acute lymphoblastic leukaemia. Br. J. Cancer, 87, 994–9.CrossRefGoogle ScholarPubMed
, , et al. (2001). Birthweight, early environment, and genetics: a study of twins discordant for acute myocardial infarction. Lancet, 357, 1997–2001.CrossRefGoogle ScholarPubMed
, and et al. (2000). Birth characteristics and subsequent risk for breast cancer in very young women. Am. J. Epidemiol., 152, 1121–8.CrossRefGoogle ScholarPubMed
, , et al. (2000). Risk of testicular cancer in men with abnormal semen characteristics: cohort study. BMJ, 321, 789–92.CrossRefGoogle ScholarPubMed
, , , and (2000). Maternal pregnancy estriol levels in relation to anamnestic and fetal anthropometric data. Epidemiology, 11, 315–19.CrossRefGoogle ScholarPubMed
, , et al. (2001). in utero exposures and breast cancer: a study of opposite-sexed twins. J. Natl. Cancer Inst., 93, 60–2.CrossRefGoogle ScholarPubMed
, , , and (2002). Maternal age, anthropometrics and pregnancy oestriol. Paediatr. Perinat. Epidemiol., 16, 149–53.CrossRefGoogle ScholarPubMed
and (2003a). Preterm birth, birthweight, and subsequent risk of female breast cancer. Br. J. Cancer, 89, 1664–6.CrossRefGoogle Scholar
and (2003b). Maternal lung cancer and testicular cancer risk in the offspring. Cancer Epidemiol. Biomarkers Prev., 12, 643–6.Google Scholar
, , and (1985). Human placental lactogen and dU-oestrogen levels in normal twin pregnancies. Acta Genet. Med. Gemellol. (Roma), 34, 59–65.CrossRefGoogle ScholarPubMed
, and (1989). Risk of cancer among children exposed to atomic bomb radiation in utero: a review. IARC Sci. Publ., 96, 365–74.Google Scholar
, and (1990). Testicular cancer trends in the Canton of Vaud, Switzerland, 1974–1987. Br. J. Cancer, 62, 871–3.CrossRefGoogle Scholar
, and (1979). Fetal growth and placental function assessed by urinary estriol excretion before the onset of pre-eclampsia. Am. J. Obstet. Gynecol., 135, 344–7.CrossRefGoogle ScholarPubMed
, , et al. (2003). Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort. BMJ, 326, 248.CrossRefGoogle ScholarPubMed
, , et al. (2003). Birthweight and risk of early-onset breast cancer (Denmark). Cancer Causes Control, 14, 61–4.CrossRefGoogle Scholar
, , et al. (1996). Birthweight as a risk factor for breast cancer. Lancet, 348, 1542–6.CrossRefGoogle ScholarPubMed
(1989). Decreased testicular cancer risk in men born in wartime. J. Natl. Cancer Inst., 81, 1668–9.CrossRefGoogle ScholarPubMed
, , , and et al. (1986). Hormonal risk factors in testicular cancer: a case-control study. Am. J. Epidemiol, 124, 39–52.CrossRefGoogle ScholarPubMed
Nylander, P. P. S. (1983). The phenomenon of twinning. In Obstetrical Epidemiology (ed. ). London: Academic Press, pp. 143–65.Google Scholar
, , and (2003). Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res. Treat., 78, 223–76.CrossRefGoogle ScholarPubMed
, , et al. (2002). Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States). Cancer Causes Control, 13, 753–8.CrossRefGoogle Scholar
, , , and (1987). Time trends and occupational differences in cancer of the testis in New Zealand. Cancer, 59, 1677–82.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
, , L. et al. (2004). Women smoking and testicular cancer: one epidemic causing another?Int. J. Cancer, 109, 941–4.CrossRefGoogle Scholar
, , , and (1991). Occurrence of testicular cancer in patients operated on for cryptorchidism and inguinal hernia. J. Urol., 146, 1291–4.CrossRefGoogle ScholarPubMed
, , et al. (1998). Retrospective analysis of birthweight and prostate cancer in the Health Professionals Follow-up Study. Am. J. Epidemiol., 147, 1140–4.CrossRefGoogle ScholarPubMed
, , , and (1990). Rise in prostatic cancer incidence associated with increased use of transurethral resection. J. Natl. Cancer Inst., 82, 1624–8.CrossRefGoogle ScholarPubMed
, , , and (1992). Birth order and risk of testicular cancer. Cancer Causes Control., 3, 265–72.CrossRefGoogle ScholarPubMed
and (1997). Neonatal oestrogen exposure up-regulates oestrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology, 138, 1801–9.CrossRefGoogle ScholarPubMed
, , and (2002). Perinatal determinants of germ-cell testicular cancer in relation to histological subtypes. Br. J. Cancer, 87, 545–50.CrossRefGoogle ScholarPubMed
, , et al. (2004a). Fecundity and twinning rates as measures of fertility before diagnosis of germ-cell testicular cancer. J. Natl. Cancer Inst., 96, 145–7.CrossRefGoogle Scholar
, , et al. (2004b). Birth order, sibship size, and risk for germ-cell testicular cancer. Epidemiology, 15, 323–9.CrossRefGoogle Scholar
, and Le Bars, S. (1988). Urocytogram, an index of maturity in premature infants. Biol. Neonate, 54, 93–9.CrossRefGoogle ScholarPubMed
, , Exbom, A. and Cnattingius, S. (2001). Tall or short? Twenty years after pre-eclampsia exposure in utero: comparisons of final height, body mass index, waist-to-hip ratio, and age at menarche among women, exposed and unexposed to pre-eclampsia during fetal life. Pediatr. Res., 49, 763–9.CrossRefGoogle ScholarPubMed
and (1994). Do diet and androgens alter prostate cancer risk via a common etiologic pathway?J. Natl. Cancer Inst., 86, 252–4.CrossRefGoogle Scholar
, , et al. (1996). Perinatal factors and risk of breast cancer. Epidemiology, 7, 34–7.CrossRefGoogle ScholarPubMed
, , et al. (2002). Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population. Br. J. Cancer, 86, 84–8.CrossRefGoogle Scholar
, , et al. (1980). The epidemiology of testicular cancer in young adults. Am. J. Epidemiol., 112, 232–46.CrossRefGoogle ScholarPubMed
, and et al. (1985). Ovarian hyperstimulation syndrome in preterm infants. Pediatr. Res., 19, 548–52.CrossRefGoogle ScholarPubMed
(1995). Reproductive biology: another DDT connection. Nature, 375, 538–9.CrossRefGoogle ScholarPubMed
and (1993). Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?Lancet, 341, 1392–5.CrossRefGoogle ScholarPubMed
, and et al. (1987). Prenatal and familial associations of testicular cancer. Br. J. Cancer, 55, 571–7.CrossRefGoogle ScholarPubMed
, , and (1995). High birthweight as a predictor of prostate cancer risk. Epidemiology, 6, 423–4.CrossRefGoogle ScholarPubMed
, , et al. (2002). Early life factors in relation to breast cancer risk in postmenopausal women. Cancer Epidemiol. Biomarkers Prev., 11, 207–10.Google ScholarPubMed
and (1992). Mammary gland mass and breast cancer risk. Epidemiology, 3, 523–6.CrossRefGoogle ScholarPubMed
, and (1995). Trends in incidence of testicular cancer in Norway 1955–1992. Eur. J. Cancer, 31A, 2044–8.CrossRefGoogle ScholarPubMed
, , and (1998). Maternal health and pre- and perinatal characteristics in the etiology of testicular cancer: a prospective population- and register-based study on Norwegian males born between 1967 and 1995. Cancer Causes Control, 9, 475–86.CrossRefGoogle ScholarPubMed
, , et al. (2002). birthweight as a predictor of breast cancer: a case–control study in Norway. Br. J. Cancer, 86, 89–91.CrossRefGoogle ScholarPubMed
, , , and (1994). Season of birth and breast cancer risk in Sweden. Br. J. Cancer, 70, 564–8.CrossRefGoogle ScholarPubMed
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