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4 - A Comparative Genetic Analysis of Acellular Cementum

from Part I - The Biology of Cementum

Published online by Cambridge University Press:  20 January 2022

By
Amber E. Trujillo ,
Alex R. DeCasien ,
Mareike C. Janiak ,
Stephan Naji  and
Todd R. Disotell
Edited by
Stephan Naji ,
William Rendu  and
Lionel Gourichon
Stephan Naji
Affiliation:
New York University
William Rendu
Affiliation:
University of Bordeaux (CNRS)
Lionel Gourichon
Affiliation:
Université de Nice, Sophia Antipolis
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Summary

This chapter details a comparative genetic analysis of several candidate genes associated with acellular cementum, namely ALPL, BMP-2, BMP-7, and ARNTL. More than 40 species of mammals, reptiles, and birds were included in this analysis. For each gene, we investigated the type of selection that best characterized its evolutionary history, identified species in which these genes were recently subject to positive selection, and demonstrated specific behavioral and morphological characteristics that influence the selection pressure on these genes. We found that, overall, ALPL, BMP-2, BMP-7, and ARNTL have been subject to purifying selection in the examined taxa; however, recent positive selection on three of these genes was identified in species that have experienced recent, rapid evolutionary changes in dental anatomy. In addition, we found that several species-specific characteristics, including diet, lifespan, tooth count, and radicularity, significantly predicted lineage-specific selection pressure on these genes. This chapter demonstrates that cementum genes have undergone significant evolutionary changes, and that certain phenotypic characteristics have influenced such changes

Keywords

Acellular cementumcomparative geneticsselection pressurecementogenesis
Type
Chapter
Information
Dental Cementum in Anthropology , pp. 83 - 93
Publisher: Cambridge University Press
Print publication year: 2022

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