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1 - Introduction to Biopharmaceutical Processes

Published online by Cambridge University Press:  22 September 2018

David Pfister ,
Lucrèce Nicoud  and
Massimo Morbidelli
David Pfister
Affiliation:
Ypso Facto
Lucrèce Nicoud
Affiliation:
Massachusetts Institute of Technology
Massimo Morbidelli
Affiliation:
Eidgenössische Technische Hochschule Zürich
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Summary

This chapter provides a general introduction on biopharmaceutical processes. The first part presents a brief description of the single unit operations typically encountered during the manufacturing process, including cell culture, purification, viral inactivation, formulation. The second part addresses the potential benefits of continuous technologies in the biopharmaceutical industry both for the upstream and downstream parts of the process, focusing on perfusion bioreactors and continuous counter-current chromatographic processes, respectively. The chapter finishes with a discussion on process integration.

Keywords

perfusioncell cultureupstreamdownstreamfed-batchbioreactorsglycoformscharge variantsimpuritiesintegration
Type
Chapter
Information
Continuous Biopharmaceutical Processes
Chromatography, Bioconjugation, and Protein Stability
 , pp. 1 - 26
Publisher: Cambridge University Press
Print publication year: 2018

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