Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2025-01-05T14:35:37.079Z Has data issue: false hasContentIssue false

Case 51 - Nothing Can Be Done

from Part 10 - Management Misadventures

Published online by Cambridge University Press:  03 November 2020

Keith Josephs ,
Federico Rodriguez-Porcel ,
Rhonna Shatz ,
Daniel Weintraub  and
Alberto Espay
Keith Josephs
Affiliation:
Mayo Clinic Alzheimer’s Disease Research Center
Federico Rodriguez-Porcel
Affiliation:
Medical University of South Carolina
Rhonna Shatz
Affiliation:
University of Cincinnati
Daniel Weintraub
Affiliation:
University of Pennsylvania
Alberto Espay
Affiliation:
University of Cincinnati
Get access

Summary

This 70-year-old right-handed man presented with a 4-year history of worsening forgetfulness. Since his retirement as a lawyer he noticed increasing difficulties recalling recent conversations and finding words. His family reported he was unintentionally repeating questions and stories. In addition, he was not as active as before and spent more time watching TV. One year earlier, he discussed his concerns with his primary care physician whose evaluation revealed a Mini-Mental State Examination score (MMSE) of 24/30, unremarkable screening labs, and a brain MRI which showed mild generalized atrophy. He was told he had mild cognitive impairment (MCI) which is considered a predementia stage. He was on donepezil 10 mg daily and memantine 10 mg twice daily, with no meaningful changes in his cognition or function.

Type
Chapter
Information
Common Pitfalls in Cognitive and Behavioral Neurology
A Case-Based Approach
 , pp. 164 - 168
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Akbaraly, T. N. et al. 2009. Leisure activities and the risk of dementia in the elderly: results from the Three-City Study. Neurology 73(11) 854–861.CrossRefGoogle ScholarPubMed
Fotuhi, M., Do, D. and Jack, C. 2012. Modifiable factors that alter the size of the hippocampus with ageing. Nature Reviews Neurology 8 189.CrossRefGoogle ScholarPubMed
Hughes, C. P. et al. 1982. A new clinical scale for the staging of dementia. Br J Psychiatry 140 566–572.Google Scholar
Karssemeijer, E. G. A. et al. 2017. Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: a meta-analysis. Ageing Res Rev 40 75–83.Google Scholar
Kuiper, J. S. et al. 2015. Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 22 39–57.Google Scholar
Livingston, G. et al. 2017. Dementia prevention, intervention, and care. Lancet 390(10113) 2673–2734.CrossRefGoogle ScholarPubMed
Morris, M. C. et al. 2015a. MIND diet slows cognitive decline with aging. Alzheimers Dement 11(9) 1015–1022.CrossRefGoogle ScholarPubMed
Morris, M. C. et al. 2015b. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement 11(9) 1007–1014.CrossRefGoogle ScholarPubMed
Petersen, R. C. et al. 2018. Practice guideline update summary: mild cognitive impairment: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 90(3) 126–135.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×