Book contents
- Frontmatter
- Contents
- Contributors
- Case studies
- Preface to the second edition
- Preface to the first edition
- Abbreviations
- Introduction
- Section 1 Physiological MR techniques
- Section 2 Cerebrovascular disease
- Chapter 13 Cerebrovascular disease
- Chapter 14 Magnetic resonance spectroscopy in stroke
- Chapter 15 Diffusion and perfusion MR in stroke
- Chapter 16 Arterial spin labeling in stroke
- Chapter 17 Magnetic resonance diffusion tensor imaging in stroke
- Chapter 18 Magnetic resonance spectroscopy in severe obstructive carotid artery disease
- Chapter 19 Perfusion and diffusion imaging in chronic carotid disease
- Chapter 20 Susceptibility imaging and stroke
- Section 3 Adult neoplasia
- Section 4 Infection, inflammation and demyelination
- Section 5 Seizure disorders
- Section 6 Psychiatric and neurodegenerative diseases
- Section 7 Trauma
- Section 8 Pediatrics
- Section 9 The spine
- Index
- References
Chapter 20 - Susceptibility imaging and stroke
from Section 2 - Cerebrovascular disease
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Contributors
- Case studies
- Preface to the second edition
- Preface to the first edition
- Abbreviations
- Introduction
- Section 1 Physiological MR techniques
- Section 2 Cerebrovascular disease
- Chapter 13 Cerebrovascular disease
- Chapter 14 Magnetic resonance spectroscopy in stroke
- Chapter 15 Diffusion and perfusion MR in stroke
- Chapter 16 Arterial spin labeling in stroke
- Chapter 17 Magnetic resonance diffusion tensor imaging in stroke
- Chapter 18 Magnetic resonance spectroscopy in severe obstructive carotid artery disease
- Chapter 19 Perfusion and diffusion imaging in chronic carotid disease
- Chapter 20 Susceptibility imaging and stroke
- Section 3 Adult neoplasia
- Section 4 Infection, inflammation and demyelination
- Section 5 Seizure disorders
- Section 6 Psychiatric and neurodegenerative diseases
- Section 7 Trauma
- Section 8 Pediatrics
- Section 9 The spine
- Index
- References
Summary
Basic principles of susceptibility contrast
Magnetic resonance sequences that take advantage of susceptibility effects to demonstrate pathology are powerful and sensitive aids for diagnostic imaging. An important distinction should be highlighted at this point. Although the term susceptibility-weighted imaging (SWI) has been used in the past to refer to T2*-weighted gradient recall echo (GRE) techniques, the more recent convention is to reserve this term for a distinct new sequence utilizing both magnitude and phase information. The bulk of the stroke-related research discussed in this chapter relates to conventional T2*-weighted GRE sequences; susceptibility sequences and SWI are discussed in Ch. 10. In particular, one of the key applications of susceptibility sequences is the identification of hemorrhage and blood products.
The evolution of blood breakdown products undergoes the orderly transition through oxyhemoglobin, deoxyhemoglobin, intracellular methemoglobin, extracellular methemoglobin, and ultimately hemosiderin.[1] The MRI appearance of hemorrhage is determined by the magnetic properties and paramagnetic effects of the hemoglobin breakdown products at different stages of iron oxidation. Deoxyhemoglobin, intracellular methemoglobin, and hemosiderin have many unpaired electrons and these are the paramagnetic breakdown products of hemoglobin.[2–4]
- Type
- Chapter
- Information
- Clinical MR NeuroimagingPhysiological and Functional Techniques, pp. 273 - 288Publisher: Cambridge University PressPrint publication year: 2009