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Case 12 - “I Am in Hell and I Will Die in Hell”

Treatment-Resistant Depression and Electroconvulsive Therapy

from Section 2 - Mood Disorders

Published online by Cambridge University Press:  31 October 2024

Matthew Gibfried
Affiliation:
Saint Louis University School of Medicine, Missouri
George T. Grossberg
Affiliation:
Saint Louis University School of Medicine, Missouri
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Summary

Major depressive disorder is a serious and life-threatening condition not uncommon to older adults. Only 60-70% of patients respond to an adequate trial of two different antidepressants. Reasonable strategies to address treatment-resistant depression in older adults include adding an antidepressant in another class or adding one or more of many available augmentation agents. When patients have treatment-resistant depression a clinician may need to consider nonpharmacologic therapies for depression such as electroconvulsive therapy or transcranial magnetic stimulation.

Type
Chapter
Information
Clinical Case Studies in Long-Term Care Psychiatry
Navigating Common Mental Health Challenges in Geriatric Care
, pp. 57 - 61
Publisher: Cambridge University Press
Print publication year: 2024

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References

References

Dominiak, M., Antosik-Wójcińska, A. Z., Wojnar, M., & Mierzejewski, P. (2021). Electroconvulsive therapy and age: Effectiveness, safety and tolerability in the treatment of major depression among patients under and over 65 years of age. Pharmaceuticals, 14 (6) https://doi.org/10.3390/ph14060582CrossRefGoogle ScholarPubMed
Rosenquist, P. B., Miller, B., & Pillai, A. (2014). The antipsychotic effects of ECT: A review of possible mechanisms. The Journal of ECT, 30 (2), 125131.CrossRefGoogle ScholarPubMed
Rojas, M., Ariza, D., Ortega, Á., Riaño-Garzón, M. E., Chávez-Castillo, M., Pérez, J. L., Cudris-Torres, L., Bautista, M. J., Medina-Ortiz, O., Rojas-Quintero, J., & Bermúdez, V. (2022). Electroconvulsive therapy in psychiatric disorders: A narrative review exploring neuroendocrine–immune therapeutic mechanisms and clinical implications. International Journal of Molecular Sciences, 23 (13). https://doi.org/10.3390/ijms23136918CrossRefGoogle ScholarPubMed
Kelly, M. S., Oliveira-Maia, A. J., Bernstein, M., Stern, A. P., Press, D. Z., Pascual-Leone, A., & Boes, A. D. (2017). Initial response to transcranial magnetic stimulation treatment for depression predicts subsequent response. The Journal of Neuropsychiatry and Clinical Neurosciences, 29 (2), 179. www.ncbi.nlm.nih.gov/pmc/articles/PMC5592731/CrossRefGoogle ScholarPubMed
Mancusi, G., Santovito, M. C., Marrangone, C., Martino, F., Santorelli, M., Miuli, A., Carlo, F. D., Signorelli, M. S., Clerici, M., Pettorruso, M., & Martinotti, G. (2023). Investigating the role of maintenance TMS protocols for major depression: Systematic review and future perspectives for personalized nterventions. Journal of Personalized Medicine, 13 (4). https://doi.org/10.3390/jpm13040697Google Scholar

Further Reading

Bottomley, J. M., LeReun, C., Diamantopoulos, A., Mitchell, S., & Gaynes, B. N. (2020). Vagus nerve stimulation (VNS) therapy in patients with treatment-resistant depression: A systematic review and meta-analysis. Comprehensive Psychiatry, 98, 152156.CrossRefGoogle Scholar
Desai, A., & Grossberg, G. (2018). Psychiatric Consultation in Long-Term Care. A Guide for Healthcare Professionals. 2nd ed. (Cambridge University Press.) pp. 139142.Google Scholar
van Rooij, S. J., Riva-Posse, P., & McDonald, W. M. (2020). The efficacy and safety of neuromodulation treatments in late-life depression. Current Treatment Options in Psychiatry, 7, 337348.CrossRefGoogle ScholarPubMed

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