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19 - Nuclear imaging for the assessment of patients with carotid artery atherosclerosis

from Functional plaque imaging

Published online by Cambridge University Press:  03 December 2009

By
John R. Davies  and
Peter L. Weissberg
Edited by
Jonathan Gillard ,
Martin Graves ,
Thomas Hatsukami  and
Chun Yuan
John R. Davies
Affiliation:
University of Cambridge Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 2QQ, UK
Peter L. Weissberg
Affiliation:
University of Cambridge Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 2QQ, UK
Jonathan Gillard
Affiliation:
University of Cambridge
Martin Graves
Affiliation:
University of Cambridge
Thomas Hatsukami
Affiliation:
University of Washington
Chun Yuan
Affiliation:
University of Washington
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Summary

Introduction

Atherosclerosis affecting the carotid arteries is an important cause of thromboembolic stroke and thus, its identification in patients at risk of stroke is desirable. Over the past three decades many attempts have been made to utilize nuclear imaging technology to identify atherosclerotic lesions in the carotid arteries. Early studies focused on providing the clinician with noninvasive alternatives for angiography such as ultrasound, computerized tomography (CT) and magnetic resonance (MR). The ability to identify lesions in large vessels such as the carotid artery, meant that developing nuclear imaging techniques as a means of simply confirming the presence of atherosclerosis was no longer justified. However, interest in developing novel nuclear imaging techniques has resurfaced following the realization that, much like coronary disease and myocardial infarction, thromboembolic stroke caused by carotid atheroma occurs as a result of plaque rupture. It is now widely accepted that the risk of plaque rupture is dictated by particular pathological processes at the cellular and molecular level, the identification of which nuclear imaging is ideally suited.

This chapter begins by outlining the basic principles that underpin nuclear imaging. This is followed by an overview of the cellular and molecular pathways that predispose to plaque inflammation, rupture, and thrombosis. The chapter then concentrates on methods for targeting these pathways by way of nuclear imaging. As well as detailing the relevant human studies, this section also outlines the most promising techniques that have so far only been tested in experimental models.

Type
Chapter
Information
Carotid Disease
The Role of Imaging in Diagnosis and Management
 , pp. 251 - 271
Publisher: Cambridge University Press
Print publication year: 2006

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