Inflammation and Organ Damage during Cardiopulmonary Bypass

doi:10.1017/9781009008143.017

Chapter 17 - Inflammation and Organ Damage during Cardiopulmonary Bypass

Published online by Cambridge University Press: 24 October 2022

R Clive Landis and

Sherif Assaad

Edited by

Florian Falter ,

Albert C. Perrino, Jr and

Robert A. Baker

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Florian Falter: Affiliation:
Royal Papworth Hospital, Cambridge
Albert C. Perrino, Jr: Affiliation:
Yale University Medical Center, Connecticut
Robert A. Baker: Affiliation:
Flinders Medical Centre, Adelaide

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Summary

The transition from physiological circulation to cardiopulmonary bypass (CPB) represents a major change to the homeostasis of the body including alterations in the distribution of blood flow and oxygen delivery to organs, which may at least in part account for the organ dysfunction during CPB. Layered on top of disturbances in oxygen delivery is a systemic inflammatory response triggered by contact of leukocytes and other blood components with the artificial surfaces of the extracorporeal circuit. While most of these host responses are appropriate and desirable in the context of a localized injury or infection, they are not desirable systemically and contribute to the morbidity and mortality associated with cardiopulmonary bypass.

Keywords

Systemic Inflammatory Response Endothelial Linking Gastrointestinal Dysfunction Pulmonary Dysfunction Myocardial Dysfunction Pulsatile Flow Leukocyte Depletion Heparin-bonded Tubing

Type: Chapter
Information: Cardiopulmonary Bypass , pp. 166 - 174

DOI: https://doi.org/10.1017/9781009008143.017 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2022

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References

Suggested Further Reading

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