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6.2 - The Stress Response and Glucocorticoids

from 6 - Modulators

Published online by Cambridge University Press:  08 November 2023

By
Jeffrey W. Dalley  and
Joe Herbert
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

This section summarises the psychology and neurobiology of stress responses in humans. It considers the adaptive value of stress in enabling humans to detect real or perceived threats in the environment and, through learning, to build resilience through helpful coping responses. The conditions that favour ‘toxic’ forms of stress to prevail and so cause chronic metabolic, inflammatory and cognitive disorders are highlighted and discussed from the perspective of dysregulated cortisol signalling.

Type
Chapter
Information
Cambridge Textbook of Neuroscience for Psychiatrists , pp. 300 - 306
Publisher: Cambridge University Press
Print publication year: 2023

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References

Argentieri, MA, Nagarajan, S, Seddighzadeh, B, Baccarelli, AA, Shields, AE (2017). Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development. EBioMedicine 18: 327–350.CrossRefGoogle ScholarPubMed
de Kloet, ER, de Kloet, SF, de Kloet, CS, de Kloet, AD (2019). Top-down and bottom-up control of stress-coping. J Neuroendocrinol 31: e12675.CrossRefGoogle ScholarPubMed
Dias-Ferreira, E, Sousa, JC, Melo, I et al. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science 325: 621–625.CrossRefGoogle ScholarPubMed
Koolhaas, JM, Bartolomucci, A, Buwalda, B et al. (2011). Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev 35: 1291–1301.CrossRefGoogle ScholarPubMed
McEwen, BS, Gianaros, PJ (2011). Stress- and allostasis-induced brain plasticity. Annu Rev Med 62: 431–445.CrossRefGoogle ScholarPubMed
Selye, H (1955). Stress and disease. Science 122: 625–631.CrossRefGoogle ScholarPubMed
Uno, H, Tarara, R, Else, JG, Suleman, MA, Sapolsky, RM (1989). Hippocampal damage associated with prolonged and fatal stress in primates. J Neurosci 9: 1705–1711.CrossRefGoogle ScholarPubMed
van der Goes, MC, Jacobs, JW, Bijlsma, JW (2014). The value of glucocorticoid co-therapy in different rheumatic diseases: positive and adverse effects. Arthritis Res Ther 16: S2.CrossRefGoogle ScholarPubMed

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