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5.9 - Reward, Pleasure and Motivation

from 5 - Neural Circuits

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Rewards are crucial for individual and evolutionary survival and have three major functions: learning, approach (motivation, decision making) and emotion. Neurophysiological work in animals has elucidated neuronal mechanisms for learning and approach. Key brain centres for reward are dopamine neurons, the striatum, the orbitofrontal cortex and the amygdala, each of them interconnected and associated with other brain structures in which reward information is often processed in conjunction with sensory and motor mechanisms. Although it is difficult to make categorical functional distinctions between highly connected brain structures, some simplification is possible: dopamine neurons play a prime role in reinforcement learning and updating of economic decision variables; striatum neurons confer reward information to movements and decisions; the orbitofrontal cortex has a prime function in decisions; and the amygdala, classically known for fear processing, has a substantial role in reward processes suitable for economic decision making. Any disturbance in these crucial neuronal survival mechanisms has serious consequences for the welfare of individuals.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2023

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References

Báez-Mendoza, R, Harris, C, Schultz, W (2013). Activity of striatal neurons reflects social action and own reward. Proc Natl Acad Sci USA 110: 1663416639.CrossRefGoogle ScholarPubMed
Bermudez, MA, Schultz, W (2010). Responses of amygdala neurons to positive reward predicting stimuli depend on background reward (contingency) rather than stimulus-reward pairing (contiguity). J Neurophysiol 103: 11581170.CrossRefGoogle ScholarPubMed
Delamater, AR (1995). Outcome selective effects of intertrial reinforcement in a Pavlovian appetitive conditioning paradigm with rats. Anim Learn Behav 23: 3139.CrossRefGoogle Scholar
Dickinson, A (1980). Contemporary Animal Learning Theory. Cambridge University Press.Google Scholar
Drevets, WC, Gautier, C, Price, JC et al. (2001). Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 49: 8196.CrossRefGoogle ScholarPubMed
Grabenhorst, F, Báez-Mendoza, R, Genest, W, Deco, G, Schultz, W (2019). Primate amygdala neurons simulate decision processes of social partners. Cell 177: 986998.CrossRefGoogle ScholarPubMed
Hosokawa, T, Watanabe, M (2012). Prefrontal neurons represent winning and losing during competitive video shooting games between monkeys. J Neurosci 32: 76627671.CrossRefGoogle ScholarPubMed
O’Neill, M, Schultz, W (2010). Coding of reward risk distinct from reward value by orbitofrontal neurons. Neuron 68: 789800.CrossRefGoogle ScholarPubMed
Padoa-Schioppa, C, Assad, JA (2006). Neurons in the orbitofrontal cortex encode economic value. Nature 441: 223226.CrossRefGoogle ScholarPubMed
Pastor-Bernier, A, Stasiak, A, Schultz, W (2019). Orbitofrontal signals for two-component choice options comply with indifference curves of revealed preference theory. Nat Comm 10: 4885.CrossRefGoogle ScholarPubMed
Paton, JJ, Belova, MA, Morrison, SE, Salzman, CD (2006). The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439: 865870.CrossRefGoogle ScholarPubMed
Rescorla, RA, Wagner, AR (1972). A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement. In Black AH, Prokasy WF (eds.), Classical Conditioning II: Current Research and Theory. Appleton Century Crofts, pp. 6499.Google Scholar
Romo, R, Schultz, W (1990). Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements. J Neurophysiol 63: 592606.CrossRefGoogle ScholarPubMed
Rutledge, RB, Skandalia, N, Dayan, P, Dolan, RJ (2014). A computational and neural model of momentary subjective well-being. Proc Natl Acad Sci USA 111: 1225212257.CrossRefGoogle ScholarPubMed
Samejima, K, Ueda, Y, Doya, K, Kimura, M (2005). Representation of action-specific reward values in the striatum. Science 310: 13371340.CrossRefGoogle ScholarPubMed
Schultz, W (2011). Potential vulnerabilities of neuronal reward, risk, and decision mechanisms to addictive drugs. Neuron 69: 603617.CrossRefGoogle ScholarPubMed
Schultz, W (2015). Neuronal reward and decision signals: from theories to data. Physiol Rev 95: 853951.CrossRefGoogle ScholarPubMed
Schultz, W, Dayan, P, Montague, RR (1997). A neural substrate of prediction and reward. Science 275: 15931599.CrossRefGoogle ScholarPubMed
Stauffer, WR, Lak, A, Schultz, W (2014). Dopamine reward prediction error responses reflect marginal utility. Curr Biol 24: 24912500.CrossRefGoogle ScholarPubMed
Sutton, RS, Barto, AG (1998). Reinforcement Learning. MIT Press.Google Scholar
Tai, L-H, Lee, AM, Benavidez, N, Bonci, A, Wilbrecht, L (2012). Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value. Nat Neurosci 15: 12811289.CrossRefGoogle ScholarPubMed
Tremblay, L, Schultz, W (1999). Relative reward preference in primate orbitofrontal cortex. Nature 398: 704708.CrossRefGoogle ScholarPubMed

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