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9.15 - Perinatal Disorders

from 9 - Integrated Neurobiology of Specific Syndromes and Treatments

Published online by Cambridge University Press:  08 November 2023

By
Marisa Casanova Dias ,
Ian Jones  and
Louise M. Howard
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

In this section, we describe psychiatric disorders in the perinatal period, with a focus on understanding the triggering of mood and psychotic disorders by childbirth (postpartum psychosis and postnatal depression). We define perinatal disorders and the perinatal period, and the issues around how these episodes of illness are dealt with in the current diagnostic classification systems – the World Health Organization’s International Classification of Diseases, 11th edition (ICD-11) and the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) [1, 2].

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Chapter
Information
Cambridge Textbook of Neuroscience for Psychiatrists , pp. 509 - 516
Publisher: Cambridge University Press
Print publication year: 2023

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References

World Health Organization. International Classification of Diseases, 11th ed. (ICD-11). World Health Organization, 2018.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5). American Psychiatric Association, 2013.Google Scholar
Casanova Dias, M, Jones, I. Perinatal psychiatry. Medicine 2020; 48(12): 774–778.CrossRefGoogle Scholar
Shorey, S, Chee, CYI, Ng, ED et al. Prevalence and incidence of postpartum depression among healthy mothers: a systematic review and meta-analysis. J Psychiatr Res 2018; 104: 235–248.CrossRefGoogle ScholarPubMed
Howard, LM, Molyneaux, E, Dennis, CL et al. Non-psychotic mental disorders in the perinatal period. Lancet 2014; 384(9956): 1775–1788.CrossRefGoogle ScholarPubMed
VanderKruik, R, Barreix, M, Chou, D et al. The global prevalence of postpartum psychosis: a systematic review. BMC Psychiatry 2017; 17(1): 272.CrossRefGoogle ScholarPubMed
Munk-Olsen, T, Laursen, TM, Pedersen, CB, Mors, O, Mortensen, PB. New parents and mental disorders. JAMA 2006; 296(21): 2582.CrossRefGoogle ScholarPubMed
Kendell, RE, Chalmers, JC, Platz, C. Epidemiology of puerperal psychoses. Br J Psychiatry 1987; 150: 662–673.CrossRefGoogle ScholarPubMed
Martin, JL, McLean, G, Martin, D, Cantwell, R, Smith, DJ. Admission to psychiatric hospital for mental illnesses 2 years prechildbirth and postchildbirth in Scotland: a health informatics approach to assessing mother and child outcomes. BMJ Open 2017; 7(9): e016908.CrossRefGoogle Scholar
Payne, JL, Maguire, J. Pathophysiological mechanisms implicated in postpartum depression. Front Neuroendocrinol 2019; 52: 165–180.CrossRefGoogle ScholarPubMed
Bloch, M. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 2000; 157(6): 924–930.CrossRefGoogle ScholarPubMed
Schiller, CE, Meltzer-Brody, S, Rubinow, DR. The role of reproductive hormones in postpartum depression. CNS Spectr 2019; 20: 48–59.CrossRefGoogle Scholar
Meltzer-Brody, S, Stuebe, A, Dole, N et al. Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (PPD). J Clin Endocrinol Metab 2011; 96(1): E40–E47.CrossRefGoogle ScholarPubMed
Meltzer-Brody, S, Colquhoun, H, Riesenberg, R et al. Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet 2018; 392(10152): 1058–1070.CrossRefGoogle ScholarPubMed
Lawson, A, Murphy, KE, Sloan, E, Uleryk, E, Dalfen, A. The relationship between sleep and postpartum mental disorders: a systematic review. J Affect Disord 2015; 176: 65–77.CrossRefGoogle ScholarPubMed
Sharma, V, Smith, A, Khan, M. The relationship between duration of labour, time of delivery, and puerperal psychosis. J Affect Disord 2004; 83(2–3): 215–220.CrossRefGoogle ScholarPubMed
Lewis, KJS, Di Florio, A, Forty, L et al. Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. J Affect Disord 2018; 225: 624–629.CrossRefGoogle ScholarPubMed
Robinson, DP, Klein, SL. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Horm Behav 2012; 62(3): 263–271.CrossRefGoogle ScholarPubMed
Osborne, LM, Monk, C. Perinatal depression: the fourth inflammatory morbidity of pregnancy? Theory and literature review. Psychoneuroendocrinology 2013; 38(10): 1929–1952.CrossRefGoogle ScholarPubMed
Blackmore, ER, Moynihan, JA, Rubinow, DR et al. Psychiatric symptoms and proinflammatory cytokines in pregnancy. Psychosom Med 2011; 73(8): 656–663.CrossRefGoogle ScholarPubMed
Bergink, V, Burgerhout, KM, Weigelt, K et al. Immune system dysregulation in first-onset postpartum psychosis. Biol Psychiatry 2013; 73(10): 1000–1007.CrossRefGoogle ScholarPubMed
Bergink, V, Armangue, T, Titulaer, MJ et al. Autoimmune encephalitis in postpartum psychosis. Am J Psychiatry 2015; 172(9): 901–908.CrossRefGoogle ScholarPubMed
Bergink, V, Pop, VJM, Nielsen, PR et al. Comorbidity of autoimmune thyroid disorders and psychiatric disorders during the postpartum period: a Danish nationwide register-based cohort study. Psychol Med 2018; 48(08): 1291–1298.CrossRefGoogle ScholarPubMed
Rackers, HS, Thomas, S, Williamson, K, Posey, R, Kimmel, MC. Emerging literature in the microbiota–brain axis and perinatal mood and anxiety disorders. Psychoneuroendocrinology 2018; 95: 86–96.CrossRefGoogle ScholarPubMed
Viktorin, A, Meltzer-Brody, S, Kuja-Halkola, R et al. Heritability of perinatal depression and genetic overlap with nonperinatal depression. Am J Psychiatry 2016; 173(2): 158–165.CrossRefGoogle ScholarPubMed
Jones, I, Craddock, N. Searching for the puerperal trigger: molecular genetic studies of bipolar affective puerperal psychosis. Psychopharmacol Bull 2007; 40(2): 115–128.Google ScholarPubMed
Jones, I, Hamshere, M, Nangle, J-M et al. Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16. Am J Psychiatry 2007; 164(7): 1099–1104.CrossRefGoogle ScholarPubMed
Weigelt, K, Bergink, V, Burgerhout, KM et al. Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis. Brain Behav Immun 2013; 29: 147–155.CrossRefGoogle ScholarPubMed
Pawluski, JL, Lonstein, JS, Fleming, AS. The neurobiology of postpartum anxiety and depression. Trends Neurosci 2017; 40(2): 106–120.CrossRefGoogle ScholarPubMed
Wonch, KE, de Medeiros, CB, Barrett, JA et al. Postpartum depression and brain response to infants: differential amygdala response and connectivity. Soc Neurosci 2016; 11(6): 600–617.CrossRefGoogle ScholarPubMed
Fusté, M, Pauls, A, Worker, A et al. Brain structure in women at risk of postpartum psychosis: an MRI study. Transl Psychiatry 2017; 7(12): 1286.CrossRefGoogle ScholarPubMed

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