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9.20 - Brain Stimulation

from 9 - Integrated Neurobiology of Specific Syndromes and Treatments

Published online by Cambridge University Press:  08 November 2023

By
Camilla L. Nord
Edited by
Mary-Ellen Lynall ,
Peter B. Jones  and
Stephen M. Stahl
Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

One of the best examples of translation from neuroscience to psychiatric treatment is brain stimulation, an array of techniques aimed at modulating the activity and/or plasticity of particular brain structures. Brain stimulation is not new: as far back as ancient Rome, the physician Scribonius Largus wrote of electrical stimulation to relieve migraine (although he employed a torpedo fish, a species of electric ray). Today, a number of invasive and non-invasive brain stimulation techniques show efficacy in treating psychiatric disorders. What these distinct approaches have in common is their ability to target specific neural regions more directly than traditional pharmacological or psychological approaches (see Figure 9.20.1). This capacity to influence the very circuits implicated in neuroscience studies has contributed to some transformative discoveries, but has faced key translational challenges, including response variability and inadequate placebos.

Type
Chapter
Information
Cambridge Textbook of Neuroscience for Psychiatrists , pp. 549 - 555
Publisher: Cambridge University Press
Print publication year: 2023

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References

Hallett, M. Transcranial magnetic stimulation and the human brain. Nature 2000; 406: 147–150.CrossRefGoogle ScholarPubMed
O’Reardon, JP, Solvason, HB, Janicak, PG et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biological Psychiatry 2007; 62: 1208–1216.CrossRefGoogle ScholarPubMed
Wang, X-L, Du, M-Y, Chen, T-L et al. Neural correlates during working memory processing in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2015; 56: 101–108.CrossRefGoogle ScholarPubMed
Kearney-Ramos, TE, Dowdle, LT, Lench, DH et al. Transdiagnostic effects of ventromedial prefrontal cortex transcranial magnetic stimulation on cue reactivity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2018; 3: 599–609.Google ScholarPubMed
Stagg, CJ, Lin, RL, Mezue, M et al. Widespread modulation of cerebral perfusion induced during and after transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex. Journal of Neuroscience 2013; 33: 11425–11431.CrossRefGoogle ScholarPubMed
Brunoni, AR, Moffa, AH, Sampaoi-Junior, B et al. Trial of electrical direct-current therapy versus escitalopram for depression. New England Journal of Medicine 2017; 376: 2523–2533.CrossRefGoogle ScholarPubMed
Nord, CL, Chamith Halahakoon, D, Limbachya, T et al. Neural predictors of treatment response to brain stimulation and psychological therapy in depression: a double-blind randomized controlled trial. Neuropsychopharmacology 2019; 44(9): 1613–1622.CrossRefGoogle ScholarPubMed
Filmer, HL, Mattingley, JB, Dux, PE. Modulating brain activity and behaviour with tDCS: rumours of its death have been greatly exaggerated. Cortex 2020; 123: 141–151.CrossRefGoogle ScholarPubMed
Cooney Horvath, J, Forte, JD, Carter, O. Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS). Brain Stimulation 2015 8(3): 535–550.CrossRefGoogle ScholarPubMed
Sydnor, VJ, Cieslak, M, Duprat, R et al. Cortical–subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala. Science Advances 2022; 8(25): eabn5803.CrossRefGoogle ScholarPubMed
Mayberg, HS, Lozano, AM, Voon, V et al. Deep brain stimulation for treatment-resistant depression. Neuron 2005; 45: 651–660.CrossRefGoogle ScholarPubMed
Coenen, VA, Bewernick, BH, Kayser, S et al. Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. Neuropsychopharmacology 2019; 44: 1224–1232.CrossRefGoogle ScholarPubMed
Tyagi, H, Apergis-Schoute, AM, Akram, H et al. A randomised trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive compulsive disorder: clinical and imaging evidence for dissociable effects. Biological Psychiatry 2019; 85(9): 726–734.CrossRefGoogle ScholarPubMed
Scangos, KW, Khambhati, AN, Daly, PM et al. Closed-loop neuromodulation in an individual with treatment-resistant depression. Nature Medicine 2021; 27(10): 1696–1700.CrossRefGoogle Scholar
Carmi, L, Tendler, A, Bystritsky, A et al. Efficacy and safety of deep transcranial magnetic stimulation for obsessive-compulsive disorder: a prospective multicenter randomized double-blind placebo-controlled trial. American Journal of Psychiatry 2019; 176(11): 931–938.CrossRefGoogle ScholarPubMed
Folloni, D, Verhagen, L, Mars, RB et al. Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation. Neuron 2019; 101(6): 1109–1116.e5.CrossRefGoogle ScholarPubMed
Legon, W, Strohman, A. Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability. bioRxiv 2023; https://doi.org/10.1101/2023.05.05.539593.CrossRefGoogle Scholar
Nord, CL, Lawson, RP, Dalgleish, T. Disrupted dorsal mid-insula activation during interoception across psychiatric disorders. American Journal of Psychiatry 2021; 178(8): 761–770.CrossRefGoogle ScholarPubMed
O’Connell, NE, Cossar, J, Marston, L et al. Rethinking clinical trials of transcranial direct current stimulation: participant and assessor blinding is inadequate at intensities of 2mA. PLoS One 2012; 7(10): e47514.CrossRefGoogle ScholarPubMed

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