Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-26T15:46:35.208Z Has data issue: false hasContentIssue false

4b - A Developmental Psychopathology Perspective on the Emergence of Antisocial and Borderline Personality Pathologies across the Lifespan: Commentary on Personality Pathology in Youth

from Part I - Etiology

Published online by Cambridge University Press:  24 February 2020

By
Theodore P. Beauchaine
Edited by
Carl W. Lejuez  and
Kim L. Gratz
Carl W. Lejuez
Affiliation:
University of Kansas
Kim L. Gratz
Affiliation:
University of Toledo, Ohio
Get access

Summary

Traditionally, studies of personality disorder development have focused on (1) whether adult symptoms are expressed among children and adolescents, and if so (2) ages of onset at which full syndrome criteria are met. Although such studies are necessary and important, they provide limited understanding of etiopathophysiology—the complex and interactive biological and social determinants of PDs across the lifespan. This commentary presents a brief update to our conceptual model of antisocial (ASPD) and borderline (BPD) development among boys and girls. It focuses on (1) complexity of genetic, environmental, and neurohormonal influences on subcortical vulnerability to impulsivity; (2) increasing contributions of cortically mediated emotion dysregulation in adolescence and adulthood; and (3) moderation of common genetic and neural vulnerabilities to ASPD and BPD by sex. Importantly, neural correlates of ASPD and BPD are already observed among teens who are at risk for the disorders. Implications for prevention are discussed.

Keywords

borderlineantisocialpersonality disorderdevelopmentcorticalsubcorticalpsychopathologyimpulsivityemotion dysregulation
Type
Chapter
Information
The Cambridge Handbook of Personality Disorders , pp. 94 - 98
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beauchaine, T. P. (2015). Future directions in emotion dysregulation and youth psychopathology. Journal of Clinical Child and Adolescent Psychology, 44, 875–896.Google Scholar
Beauchaine, T. P., & Cicchetti, D. (2016). A new generation of comorbidity research in the era of neuroscience and the Research Domain Criteria. Development and Psychopathology, 28, 891–894.Google Scholar
Beauchaine, T. P., & Constantino, J. N. (2017). Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity. Biomarkers in Medicine, 11, 769–780.Google Scholar
Beauchaine, T. P., Constantino, J. N., & Hayden, E. P. (2018). Psychiatry and developmental psychopathology: Unifying themes and future directions. Comprehensive Psychiatry, 87, 143–152.Google Scholar
Beauchaine, T. P., Hinshaw, S. P., & Bridge, J. A. (2019). Nonsuicidal self-injury and suicidal behaviors in maltreated girls with ADHD: The case for targeted prevention in preadolescence. Clinical Psychological Science, 7, 643–667.Google Scholar
Beauchaine, T. P., Klein, D. N., Crowell, S. E., Derbidge, C., & Gatzke-Kopp, L. M. (2009). Multifinality in the development of personality disorders: A biology × sex × environment interaction model of antisocial and borderline traits. Development and Psychopathology, 21, 735–770.Google Scholar
Beauchaine, T. P., Neuhaus, E., Brenner, S. L., & Gatzke-Kopp, L. (2008). Ten good reasons to consider biological processes in prevention and intervention research. Development and Psychopathology, 20, 745–774.Google Scholar
Beauchaine, T. P., Sauder, C. L., Derbidge, C. M., & Uyeji, L. L. (2019). Self-injuring adolescent girls exhibit insular cortex volumetric abnormalities that are similar to those observed in adults with borderline personality disorder. Development and Psychopathology. Advance Online Publication.CrossRefGoogle Scholar
Beauchaine, T. P., & Zisner, A. (2017). Motivation, emotion regulation, and the latent structure of psychopathology: An integrative and convergent historical perspective. International Journal of Psychophysiology, 119, 108–118.Google Scholar
Beauchaine, T. P., Zisner, A. R., & Hayden, E. P. (2019). Neurobiological mechanisms of psychopathology and treatment action. In Ollendick, T. H., White, S. W., & White, B. A. (Eds.), The Oxford Handbook of Clinical Child and Adolescent Psychology (pp. 699–722). New York: Oxford University Press.Google Scholar
Beauchaine, T. P., Zisner, A. R., & Sauder, C. L. (2017). Trait impulsivity and the externalizing spectrum. Annual Review of Clinical Psychology, 13, 343–368.Google Scholar
Birn, R. M., Roeber, B. J., & Pollak, S. D. (2017). Early childhood stress exposure, reward pathways, and adult decision making. Proceedings of the National Academy of Sciences USA, 114, 13549–13554.CrossRefGoogle ScholarPubMed
Blair, C. (2016). Developmental science and executive function. Current Directions in Psychological Science, 25, 3–7.Google Scholar
Bornovalova, M. A., Hicks, B. M., Iacono, W. G., & McGue, M. (2013). Longitudinal twin study of borderline personality disorder traits and substance use in adolescence: Developmental change, reciprocal effects, and genetic and environmental influences. Personality Disorders: Theory, Research, and Treatment, 4, 23–32.CrossRefGoogle ScholarPubMed
Cicchetti, D. (1993). Developmental psychopathology: Reactions, reflections, projections. Developmental Review, 13, 471–502.CrossRefGoogle Scholar
Crowell, S. E., Beauchaine, T. P., & Linehan, M. (2009). A biosocial developmental model of borderline personality: Elaborating and extending Linehan’s theory. Psychological Bulletin, 135, 495–510.Google Scholar
Crowell, S. E., Butner, J., Wiltshire, T. J., Munion, A. K., Yaptangco, M., & Beauchaine, T. P. (2017). Evaluating emotional and biological sensitivity to maternal behavior among depressed and self-injuring adolescent girls using nonlinear dynamics. Clinical Psychological Science, 5, 272–285.Google Scholar
De Brito, S. A., Mechelli, A., Wilke, M., Laurens, K. R., Jones, A. P., Barker, G. J., … Viding, E. (2009). Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits. Brain, 132, 843–852.Google Scholar
Finucane, B., Challman, T. D., Martin, C. L., & Ledbetter, D. H. (2016). Shift happens: Family background influences clinical variability in genetic neurodevelopmental disorders. Genetics in Medicine, 4, 302–304.Google Scholar
Gatzke-Kopp, L. M. (2011). The canary in the coalmine: Sensitivity of mesolimbic dopamine to environmental adversity during development. Neuroscience and Biobehavioral Reviews, 35, 794–803.Google Scholar
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., … Thompson, P. M. (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences USA, 101, 8174–8179.Google Scholar
Goldin, P. R., McRae, K., Ramel, W., & Gross, J. J. (2008). The neural bases of emotion regulation: Reappraisal and suppression of negative emotion. Biological Psychiatry, 63, 577–586.CrossRefGoogle ScholarPubMed
Goldman, S. J., D’Angelo, E. J., & DeMaso, D. R. (1993). Psychopathology in the families of children and adolescents with borderline personality disorder. American Journal of Psychiatry, 150, 1832–1835.Google Scholar
Gratz, K. L., Dixon-Gordon, K. L., Breetz, A., & Tull, M. (2013). A laboratory-based examination of responses to social rejection in borderline personality disorder: The mediating role of emotion dysregulation. Journal of Personality Disorders, 27, 157–171.Google Scholar
Hair, N. L., Hanson, J. L., Wolfe, B. L., & Pollak, S. D. (2015). Association of child poverty, brain development, and academic achievement. JAMA Pediatrics, 169, 822–829.Google Scholar
Kliem, S., Kröger, C., & Kosfelder, J. (2010). Dialectical behavior therapy for borderline personality disorder: A meta-analysis using mixed-effects modeling. Journal of Consulting and Clinical Psychology, 78, 936–951.Google Scholar
Krause-Utz, A., Winter, D., Niedtfeld, I., & Schmahl, C. (2014). The latest neuroimaging findings in borderline personality disorder. Current Psychiatry Reports, 16, 438.Google Scholar
Lyons-Ruth, K. (2008). Contributions of the mother–infant relationship to dissociative, borderline, and conduct symptoms in young adulthood. Infant Mental Health Journal, 29, 203–218.CrossRefGoogle ScholarPubMed
Lyons-Ruth, K., Holms, B., Sasvari-Szekely, M., Ronai, Z., Nemoda, Z., & Pauls, D. (2007). Serotonin transporter polymorphism and borderline or antisocial traits among low-income young adults. Psychiatric Genetics, 17, 339–343.Google Scholar
Ripke, S., O’Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., … Multicenter Genetic Studies of Schizophrenia Consortium. (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45, 1150–1159.Google Scholar
Sauder, C. L., Derbidge, C. M., & Beauchaine, T. P. (2016). Neural responses to monetary incentives among self-injuring adolescent girls. Development and Psychopathology, 28, 277–291.Google Scholar
Sroufe, L. A., & Rutter, M. (1984). The domain of developmental psychopathology. Child Development, 55, 17–29.Google Scholar
Stepp, S. D., Burke, J. D., Hipwell, A. E., & Loeber, R. (2012). Trajectories of ADHD and ODD as precursors of borderline personality disorder symptoms in adolescent girls. Journal of Abnormal Child Psychology, 40, 7–20.CrossRefGoogle ScholarPubMed
Yang, Y., & Raine, A. (2009). Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: A meta-analysis. Psychiatry Research, 30, 81–88.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×