We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
from Part II - Common Categories of Pharmacologic Medications to Treat Chronic Pain
Published online by Cambridge University Press: 01 December 2023
A class of analgesics structurally similar to the natural alkaloids derived from the resin of the opium poppy. Natural alkaloids are known as opiates and they include morphine and other similarly structured drugs, such as codeine, hydrocodone, and oxycodone. Synthetic derivates include hydromorphone, fentanyl, and heroin, among others (3). Three opiate receptors – µ, ?, and d – were found predominantly in the CNS. Most analgesic effect of opioids is mediated by the µ receptor. Decrease presynaptic calcium influx and increase postsynaptic potassium efflux, leading to inhibition of neuronal firing and neurotransmitter release.
To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.
