Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-23T00:39:45.709Z Has data issue: false hasContentIssue false

Chapter 38 - Cancer Pain

from Part VI - Misc

Published online by Cambridge University Press:  01 December 2023

By
Pranav Bhargava  and
Alan D. Kaye
Edited by
Omar Viswanath  and
Ivan Urits
Omar Viswanath
Affiliation:
Creighton University, Omaha
Ivan Urits
Affiliation:
Southcoast Brain & Spine Center, Wareham
Get access

Summary

Pain is quite common in patients with cancer, especially those with metastaticdisease. Oncologic pain implications: decreased quality of life, can be an indicator of the progression of a tumor, and psychosocial effects such as anxiety and depression. Cancer pain is divided into acute form and chronic form. Advances have been made in both oncology and pain management. The application of pain management into clinical oncology is still a work in progress. Pain management that is sufficient and consistent is difficult in cancer patients. Cancer pain affects a large portion of those with cancerous disease processes. Metastatic disease tends to be associated with more pain. Pain can come from the cancer itself or from the treatment. More work is needed to standardize the evaluation and treatment of cancer pain. Further work is needed to take into account each individual’s unique circumstance.

Keywords

chronic paincancer painopioidsoncologymetastasis
Type
Chapter
Information
Cambridge Handbook of Pain Medicine , pp. 308 - 318
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cherny, NI. The management of cancer pain. CA Cancer J Clin. 2000;50(2):20–70.CrossRefGoogle ScholarPubMed
Li, X-M, Xiao, W-H, Yang, P, Zhao, H-X. Psychological distress and cancer pain: Results from a controlled cross-sectional survey in China. Sci Rep. 2017;7(1):39397. https://doi.org/10.1038/srep39397.CrossRefGoogle ScholarPubMed
Breivik, H, Cherny, N, Collett, B et al. Cancer-related pain: A pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol Off J Eur Soc Med Oncol. 2009;20(8):1420–1433.CrossRefGoogle ScholarPubMed
World Health Organization. Cancer pain relief: With a guide to opioid availability. 2nd ed. World Health Organization; 1996. p. ita reproduced in Quaderni di Sanità Pubblica, Anno 21, febbraio 1998.Google Scholar
World Health Organization. Cancer pain relief. World Health Organization; 1986. p. 74.Google Scholar
Wolfe, J, Grier, HE, Klar, N et al. Symptoms and suffering at the end of life in children with cancer. N Engl J Med. 2000;342(5):326–333. https://doi.org/10.1056/NEJM200002033420506.CrossRefGoogle ScholarPubMed
Cleeland, CS, Gonin, R, Baez, L, Loehrer, P, Pandya, KJ. Pain and treatment of pain in minority patients with cancer. The Eastern Cooperative Oncology Group Minority Outpatient Pain Study. Ann Intern Med. 1997;127(9):813–816.CrossRefGoogle ScholarPubMed
Bernabei, R, Gambassi, G, Lapane, K et al. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. JAMA. 1998;279(23):1877–1882.CrossRefGoogle ScholarPubMed
Cleeland, CS, Gonin, R, Hatfield, AK et al. Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994;330(9):592–596. https://doi.org/10.1056/NEJM199403033300902.CrossRefGoogle ScholarPubMed
Klepstad, P, Kaasa, S, Cherny, N, Hanks, G, de Conno, F. Pain and pain treatments in European palliative care units: A cross sectional survey from the European Association for Palliative Care Research Network. Palliat Med. 2005;19(6):477–484.CrossRefGoogle ScholarPubMed
Weiss, SC, Emanuel, LL, Fairclough, DL, Emanuel, EJ. Understanding the experience of pain in terminally ill patients. Lancet (London, England). 2001;357(9265):1311–1315.CrossRefGoogle ScholarPubMed
Stewart, BW, Wild, CP. World cancer report 2014. World Health Organization; 2014.Google Scholar
Glaser, AW, Fraser, LK, Corner, J et al. Patient-reported outcomes of cancer survivors in England 1–5 years after diagnosis: A cross-sectional survey. BMJ Open. 2013;3(4):e002317. doi: 10.1136/bmjopen-2012-002317. PMID: 23578682; PMCID: PMC3641492.CrossRefGoogle ScholarPubMed
Elliott, J, Fallows, A, Staetsky, L et al. The health and well-being of cancer survivors in the UK: Findings from a population-based survey. Br J Cancer. 2011;105(Suppl 1):S11–S20.CrossRefGoogle ScholarPubMed
van den Beuken-van Everdingen, MHJ, de Rijke, JM, Kessels, AG et al. Prevalence of pain in patients with cancer: A systematic review of the past 40 years. Ann Oncol Off J Eur Soc Med Oncol. 2007;18(9):1437–1449.CrossRefGoogle Scholar
Le Bitoux, M-A, Stamenkovic, I. Tumor-host interactions: The role of inflammation. Histochem Cell Biol. 2008;130(6):1079–1090.CrossRefGoogle ScholarPubMed
Magee, D, Bachtold, S, Brown, M, Farquhar-Smith, P. Cancer pain: Where are we now? Pain Manag. 2019;9(1):63–79.CrossRefGoogle ScholarPubMed
Blair, JM, Zhou, H, Seibel, MJ, Dunstan, CR. Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nat Clin Pract Oncol. 2006;3(1):41–49.CrossRefGoogle ScholarPubMed
Reis-Pina, P, Lawlor, PG, Barbosa, A. Cancer-related pain management and the optimal use of opioids. Acta Med Port. 2015;28(3):376–381.CrossRefGoogle ScholarPubMed
Jost, LM. ESMO minimum clinical recommendations for the management of cancer pain. Ann Oncol Off J Eur Soc Med Oncol. 2005;16(Suppl 1):i83–i85.CrossRefGoogle ScholarPubMed
Hucker, T, Winter, N, Chou, J. Challenges and advances in pain management for the cancer patient. Curr Anesthesiol Rep. 2015;5. doi: 10.1007/s40140-015-0120-y.CrossRefGoogle Scholar
Humble, SR, Dalton, AJ, Li, L. A systematic review of therapeutic interventions to reduce acute and chronic post-surgical pain after amputation, thoracotomy or mastectomy. Eur J Pain. 2015;19(4):451–465.CrossRefGoogle ScholarPubMed
Andreae, MH, Andreae, DA. Regional anaesthesia to prevent chronic pain after surgery: A cochrane systematic review and meta-analysis. Br J Anaesth. 2013;111(5):711–720.CrossRefGoogle ScholarPubMed
Seretny, M, Currie, GL, Sena, ES et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014;155(12):2461–2470.CrossRefGoogle ScholarPubMed
Marín, A, Martín, M, Liñán, O et al. Bystander effects and radiotherapy. Rep Pract Oncol Radiother J Gt Cancer Cent Pozn Polish Soc Radiat Oncol. 2015;20(1):12–21.Google ScholarPubMed
Caraceni, A, Shkodra, M. Cancer pain assessment and classification. Cancers (Basel). 2019;11(4):510. doi: 10.3390/cancers11040510. PMID: 30974857.CrossRefGoogle ScholarPubMed
Portenoy, RK, Hagen, NA. Breakthrough pain: Definition, prevalence and characteristics. Pain. 1990;41(3):273–281.CrossRefGoogle ScholarPubMed
Deandrea, S, Corli, O, Consonni, D et al. Prevalence of breakthrough cancer pain: A systematic review and a pooled analysis of published literature. J Pain Symptom Manage. 2014;47(1):57–76.CrossRefGoogle Scholar
Portenoy, RK, Ahmed, E. Cancer pain syndromes. Hematol Oncol Clin North Am. 2018;32(3):371–386.CrossRefGoogle ScholarPubMed
Niscola, P, Tendas, A, Scaramucci, L et al. Pain in malignant hematology. Expert Rev Hematol. 2011;4(1):81–93.CrossRefGoogle ScholarPubMed
Niscola, P, Cartoni, C, Romani, C et al. Epidemiology, features and outcome of pain in patients with advanced hematological malignancies followed in a home care program: An Italian survey. Ann Hematol. 2007;86(9):671–676.CrossRefGoogle Scholar
Fainsinger, RL, Nekolaichuk, C, Lawlor, P et al. An international multicentre validation study of a pain classification system for cancer patients. Eur J Cancer. 2010;46(16):2896–2904.CrossRefGoogle ScholarPubMed
Knudsen, AK, Brunelli, C, Klepstad, P et al. Which domains should be included in a cancer pain classification system? Analyses of longitudinal data. Pain. 2012;153(3):696–703.CrossRefGoogle Scholar
Knudsen, AK, Brunelli, C, Kaasa, S et al. Which variables are associated with pain intensity and treatment response in advanced cancer patients? Implications for a future classification system for cancer pain. Eur J Pain. 2011;15(3):320–327.CrossRefGoogle ScholarPubMed
Fainsinger, RL, Nekolaichuk, CL. A “TNM” classification system for cancer pain: The edmonton classification system for cancer pain (ECS-CP). Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2008;16(6):547–555.Google Scholar
Capelli, G, De Vincenzo, RI, Addamo, A et al. Which dimensions of health-related quality of life are altered in patients attending the different gynecologic oncology health care settings? Cancer. 2002;95(12):2500–2507.CrossRefGoogle ScholarPubMed
Korfage, IJ, Essink-Bot, M-L, Mols, F et al. Health-related quality of life in cervical cancer survivors: A population-based survey. Int J Radiat Oncol Biol Phys. 2009;73(5):1501–1509.CrossRefGoogle ScholarPubMed
Kumar, SP. Utilization of brief pain inventory as an assessment tool for pain in patients with cancer: A focused review. Indian J Palliat Care. 2011;17(2):108–115.CrossRefGoogle Scholar
Ngamkham, S, Vincent, C, Finnegan, L et al. The McGill Pain Questionnaire as a multidimensional measure in people with cancer: An integrative review. Pain Manag Nurs Off J Am Soc Pain Manag Nurses. 2012;13(1):27–51.CrossRefGoogle ScholarPubMed
Dworkin, RH, Turk, DC, Revicki, DA et al. Development and initial validation of an expanded and revised version of the short-form McGill Pain Questionnaire (SF-MPQ-2). Pain. 2009;144(1–2):35–42.CrossRefGoogle ScholarPubMed
Cleeland, CS, Ryan, KM. Pain assessment: Global use of the brief pain inventory. Ann Acad Med Singapore. 1994;23(2):129–138.Google ScholarPubMed
de Wit, R, van Dam, F, Abu-Saad, HH et al. Empirical comparison of commonly used measures to evaluate pain treatment in cancer patients with chronic pain. J Clin Oncol Off J Am Soc Clin Oncol. 1999;17(4):1280. doi: 10.1200/JCO.1999.17.4.1280. PMID: 10561190.CrossRefGoogle ScholarPubMed
Grond, S, Zech, D, Diefenbach, C, Radbruch, L, Lehmann, KA. Assessment of cancer pain: A prospective evaluation in 2266 cancer patients referred to a pain service. Pain. 1996;64(1):107–114.CrossRefGoogle ScholarPubMed
Hwang, SS, Chang, VT, Fairclough, DL, Kasimis, B. Development of a cancer pain prognostic scale. J Pain Symptom Manage. 2002;24(4):366–378.CrossRefGoogle ScholarPubMed
Portenoy, RK. Treatment of cancer pain. Lancet (London, England). 2011;377(9784):2236–2247.CrossRefGoogle ScholarPubMed
Miguel, R. Interventional treatment of cancer pain: The fourth step in the World Health Organization analgesic ladder? Cancer Control. 2000;7(2):149–156.CrossRefGoogle ScholarPubMed
Vayne-Bossert, P, Afsharimani, B, Good, P, Gray, P, Hardy, J. Interventional options for the management of refractory cancer pain: What is the evidence? Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2016;24(3):1429–1438.Google ScholarPubMed
Urits, I, Jones, MR, Orhurhu, V et al. A comprehensive review of the celiac plexus block for the management of chronic abdominal pain. Curr Pain Headache Rep. 2020;24(8):42.CrossRefGoogle ScholarPubMed
Liu, WC, Zheng, ZX, Tan, KH, Meredith, GJ. Multidimensional treatment of cancer pain. Curr Oncol Rep. 2017;19(2):10.CrossRefGoogle ScholarPubMed
Hu, C, Zhang, H, Wu, W et al. Acupuncture for pain management in cancer: A systematic review and meta-analysis. Evid Based Complement Alternat Med. 2016;2016:1720239.CrossRefGoogle Scholar
Anekar, AA, Cascella, M. WHO analgesic ladder. World Health Organization; 2021.Google Scholar
Caraceni, A, Hanks, G, Kaasa, S et al. Use of opioid analgesics in the treatment of cancer pain: Evidence-based recommendations from the EAPC. Lancet Oncol. 2012;13(2):e58–e68.CrossRefGoogle ScholarPubMed
Caraceni, A, Davies, A, Poulain, P et al. Guidelines for the management of breakthrough pain in patients with cancer. J Natl Compr Canc Netw. 2013;11(Suppl 1):S29–S36.CrossRefGoogle ScholarPubMed
Fallon, M, Giusti, R, Aielli, F et al. Management of cancer pain in adult patients: ESMO clinical practice guidelines. Ann Oncol Off J Eur Soc Med Oncol. 2018;29(Suppl 4):iv166–iv191.Google ScholarPubMed
Gunnarsdottir, S, Donovan, HS, Serlin, RC, Voge, C, Ward, S. Patient-related barriers to pain management: The barriers questionnaire II (BQ-II). Pain. 2002;99(3):385–396.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×