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Chapter 6 - Intravenous Anesthetics and Adjunctive Agents

Published online by Cambridge University Press:  24 May 2023

By
Matthew M. Colontonio ,
Mitchell C. Fuller ,
Harish Bangalore Siddaiah ,
Shilpa Patil  and
Alan David Kaye
Edited by
Alan David Kaye  and
Richard D. Urman
Alan David Kaye
Affiliation:
Louisiana State University School of Medicine
Richard D. Urman
Affiliation:
Brigham and Women’s Hospital, Boston
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Summary

Intravenous (IV) anesthetics were first discovered for their clinical utility in 1656 by Sir Christopher Wren, an architect, physicist, and astronomer at the University of Oxford while using a goosequill to inject opium into a dog to produce sleep [1]. In 1909, Ludwig Burkhardt became the first surgeon to deliberately use IV ether in a 5% solution to sedate patients for head and neck surgery, finding that a higher concentration caused thrombophlebitis and hemolysis, whereas a lower concentration proved too weak a sedative. The first barbiturate hexobarbital was used in 1932, soon being used for over 10 million cases by 1944. In 1989, the first propofol lipid emulsion formulation was launched in the United States, marking the beginning of the modern age of IV sedation pharmacology [2].

Type
Chapter
Information
Cambridge Handbook of Anesthesiology , pp. 86 - 105
Publisher: Cambridge University Press
Print publication year: 2023

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References

Roberts, M, Jagdish, S. A history of intravenous anesthesia in war (1656–1988). J Anesth Hist. 2016;2(1):13–21.CrossRefGoogle ScholarPubMed
Baker, MT, Naguib, M. Propofol: the challenges of formulation. Anesthesiology. 2005;103(4):860–76.CrossRefGoogle ScholarPubMed
Weiser, TG, Regenbogen, SE, Thompson, KD, et al. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet. 2008;372(9633):139–44.Google Scholar
Schraag, S, Pradelli, L, Alsaleh, AJO, et al. Propofol vs. inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2018;18(1):162.Google Scholar
Miller, D, Lewis, SR, Pritchard, MW, et al. Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. Cochrane Database Syst Rev. 2018;8(8):CD012317.Google ScholarPubMed
Landoni, G, Lomivorotov, VV, Nigro Neto, C, et al. Volatile anesthetics versus total intravenous anesthesia for cardiac surgery. N Engl J Med. 2019;380(13):1214–25.CrossRefGoogle ScholarPubMed
Park, CH, Park, SW, Hyun, B, et al. Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial. Gastrointest Endosc. 2018;87(1):174–84.Google Scholar
Tadler, SC, Mickey, BJ. Emerging evidence for antidepressant actions of anesthetic agents. Curr Opin Anaesthesiol. 2018;31(4):439–45.Google Scholar
Mathew, SJ, Shah, A, Lapidus, K, et al. Ketamine for treatment-resistant unipolar depression: current evidence. CNS Drugs. 2012;26(3):189–204.Google Scholar
Reznik, M, Berger, K, Claassen, J. Comparison of intravenous anesthetic agents for the treatment of refractory status epilepticus. J Clin Med. 2016;5(5):54.Google Scholar
Barash, PG, Cullen, BF, Stoelting, RK, et al. Clinical anesthesia. In: Barash, PG, Cullen, BF, Stoelting, RK, et al., eds. Clinical Anesthesia, 8th ed. Philadelphia, PA: Wolters Kluwer; 2017, pp. 486–504.Google Scholar
Brohan, J, Goudra, BG. The role of GABA receptor agonists in anesthesia and sedation. CNS Drugs. 2017;31(10):845–56.CrossRefGoogle ScholarPubMed
Butterworth, JF, Mackey, DC, Wasnick, JD. Clinical anesthesiology. In: Butterworth, JF, Mackey, DC, Wasnick, JD, eds. Morgan & Mikhail’s Clinical Anesthesiology, 5th ed. New York, NY: McGraw Hill; 2013, pp. 175–88.Google Scholar
Desousa, KA. Pain on propofol injection: causes and remedies. Indian J Pharmacol. 2016;48(6):617–23.Google Scholar
Stoelting, RK, Miller, RD. Basics of anesthesia. In: Stoelting, RK, Miller, RD, eds. Basics of Anesthesia, 5th ed. Philadelphia, PA: Elsevier; 2007, pp. 97–111.Google Scholar
Feng, AY, Kaye, AD, Kaye, RJ, Belani, K, Urman, RD. Novel propofol derivatives and implications for anesthesia practice. J Anaesthesiol Clin Pharmacol. 2017;33(1):9–15.Google ScholarPubMed
Srivastava, U, Sarkar, ME, Kumar, A, et al. Comparison of clonidine and dexmedetomidine for short-term sedation of intensive care unit patients. Indian J Crit Care Med. 2014;18(7):431–6.Google ScholarPubMed
Tang, C, Xia, Z. Dexmedetomidine in perioperative acute pain management: a non-opioid adjuvant analgesic. J Pain Res. 2017;10:1899–904.CrossRefGoogle ScholarPubMed
Grewal, A. Dexmedetomidine: new avenues. J Anaesthesiol Clin Pharmacol. 2011;27(3):297–302.Google Scholar
[No authors]. Context-sensitive half-time. J Neurocrit Care. Available from: www.e-xjnc.org/journal/Figure.php?xn=jnc-8-2-x53.xml&id=f1-jnc-8-2-53&number=199&p_name=0516_199.Google Scholar
DiMasi, JA, Grabowski, HG, Hansen, RW. Innovation in the pharmaceutical industry: new estimates of R&D costs. J Health Econ. 2016;47:20–33.CrossRefGoogle ScholarPubMed
Brown, EN, Pavone, KJ, Naranjo, M. Multimodal general anesthesia: theory and practice. Anesth Analg. 2018;127(5):1246–58.Google Scholar
Swain, A, Nag, DS, Sahu, S, Samaddar, DP. Adjuvants to local anesthetics: current understanding and future trends. World J Clin Cases. 2017;5(8):307–23.CrossRefGoogle ScholarPubMed
Busch-Dienstfertig, M, Stein, C. Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain: basic and therapeutic aspects. Brain Behav Immun. 2010;24(5):683–94.CrossRefGoogle ScholarPubMed
Casserly, E, Alexander, JC. Perioperative uses of intravenous opioids in adults: general considerations. Waltham, MA: UpToDate; 2022. Available from: www.uptodate.com/contents/perioperative-uses-of-intravenous-opioids-in-adults-general-considerations.Google Scholar
Butterworth, JF, Mackey, DC, Wasnick, JD, eds. Morgan & Mikhail’s Clinical Anesthesiology, 6th ed. New York, NY: McGraw Hill; 2018.Google Scholar
Jonan, AB, Kaye, AD, Urman, RD. Buprenorphine formulations: clinical best practice strategies recommendations for perioperative management of patients undergoing surgical or interventional pain procedures. Pain Physician. 2018;21(1):E1–12.Google ScholarPubMed
Dunn, LK, Durieux, ME. Perioperative use of intravenous lidocaine. Anesthesiology. 2017;126(4):729–37.Google Scholar
George, R, Condrey, J, Wilson, S. “Oh Mg!” Magnesium: a powerful tool in the perioperative setting. 2018. Available from: www.asra.com/guidelines-articles/original-articles/article-item/asra-news/2018/07/23/-oh-mg!-magnesium-a-powerful-tool-in-the-perioperative-setting.Google Scholar
Schmidt, PC, Ruchelli, G, Mackey, SC, Carroll, IR. Perioperative gabapentinoids. Anesthesiology. 2013;119(5):1215–21.Google Scholar
Pędziwiatr, M, Mavrikis, J, Witowski, J, et al. Current status of enhanced recovery after surgery (ERAS) protocol in gastrointestinal surgery. Med Oncol. 2018;35(6):95.Google Scholar
Patel, HRH, Cerantola, Y, Valerio, M, et al. Enhanced recovery after surgery: are we ready, and can we afford not to implement these pathways for patients undergoing radical cystectomy? Eur Urol. 2014;65(2):263–6.Google Scholar
Tarıkçı Kılıç, E, Demirbilek, T, Naderi, S. Does an enhanced recovery after surgery protocol change costs and outcomes of single-level lumbar microdiscectomy? Neurosurg Focus. 2019;46(4):E10.Google Scholar
Chiou, Y-W, Ting, C-K, Wang, H-Y, Tsou, M-Y, Chang, W-K. Enhanced recovery after surgery: prediction for early extubation in video-assisted thoracic surgery using a response surface model in anesthesia. J Formos Med Assoc. 2019;118(10):1450–7.Google Scholar
Gao, S, Barello, S, Chen, L, et al. Clinical guidelines on perioperative management strategies for enhanced recovery after lung surgery. Transl Lung Cancer Res. 2019;8(6):1174–87.CrossRefGoogle ScholarPubMed
Wang, H-Y, Ting, C-K, Liou, J-Y, Chen, K-H, Tsou, M-Y, Chang, W-K. A previously published propofol–remifentanil response surface model does not predict patient response well in video-assisted thoracic surgery. Medicine (Baltimore). 2017;96(19):e6895.CrossRefGoogle Scholar
Mitra, S. Opioid-induced hyperalgesia: pathophysiology and clinical implications. J Opioid Manag. 2008;4(3):123–30.Google ScholarPubMed
Gao, M, Rejaei, D, Liu, H. Ketamine use in current clinical practice. Acta Pharmacol Sin. 2016;37(7):865–72.CrossRefGoogle ScholarPubMed
Dunkman, WJ, Manning, MW. Enhanced recovery after surgery and multimodal strategies for analgesia. Surg Clin North Am. 2018;98(6):1171–84.CrossRefGoogle ScholarPubMed
Loftus, RW, Yeager, MP, Clark, JA, et al. Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. Anesthesiology. 2010;113(3):639–46.Google Scholar
Greco, M, Capretti, G, Beretta, L, Gemma, M, Pecorelli, N, Braga, M. Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials. World J Surg. 2014;38(6):1531–41.Google Scholar
Parrish, AB, O’Neill, SM, Crain, SR, et al. An enhanced recovery after surgery (ERAS) protocol for ambulatory anorectal surgery reduced postoperative pain and unplanned returns to care after discharge. World J Surg. 2018;42(7):1929–38.CrossRefGoogle ScholarPubMed
Cowie, P, Baxter, A, McCormack, J. Total intravenous anaesthesia in children: a practical guide. Anaesth Intensive Care Med. 2019;20(6):348–52.CrossRefGoogle Scholar
Anderson, BJ, Bagshaw, O. Practicalities of total intravenous anesthesia and target-controlled infusion in children. Anesthesiology. 2019;131(1):164–85.Google Scholar
Gaynor, J, Ansermino, JM. Paediatric total intravenous anaesthesia. BJA Educ. 2016;16(11):369–73.Google Scholar

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