Book contents
- Biological Implications of Circadian Disruption
- Biological Implications of Circadian Disruption
- Copyright page
- Contents
- Contributors
- Preface
- 1 Introduction to Circadian Rhythms
- 2 Central Clock Dynamics
- 3 Melatonin, Light, and the Circadian System
- 4 Disrupted Circadian Rhythms, Stress, and Allostatic Load
- 5 Disrupted Circadian Rhythms and Mental Health
- 6 Circadian Rhythms and Cognitive Functioning
- 7 Circadian Rhythm Disruption in Aging and Alzheimer’s Disease
- 8 Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury
- 9 Disrupted Circadian Rhythms and Neuroendocrine Function in Fertility
- 10 Disrupted Circadian Rhythms and Metabolic Function
- 11 Disrupted Circadian Rhythms, Time Restricted Feeding, and Blood Pressure Regulation
- 12 Disrupted Circadian Rhythms and Immune Function
- 13 Circadian Rhythms and Cardiac Function
- 14 Disrupted Circadian Rhythms and Cancer
- 15 Light Effects across Species in Nature
- 16 Measurement and Analysis of Exposure to Light at Night in Epidemiology
- Index
- References
10 - Disrupted Circadian Rhythms and Metabolic Function
Published online by Cambridge University Press: 07 October 2023
Book contents
- Biological Implications of Circadian Disruption
- Biological Implications of Circadian Disruption
- Copyright page
- Contents
- Contributors
- Preface
- 1 Introduction to Circadian Rhythms
- 2 Central Clock Dynamics
- 3 Melatonin, Light, and the Circadian System
- 4 Disrupted Circadian Rhythms, Stress, and Allostatic Load
- 5 Disrupted Circadian Rhythms and Mental Health
- 6 Circadian Rhythms and Cognitive Functioning
- 7 Circadian Rhythm Disruption in Aging and Alzheimer’s Disease
- 8 Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury
- 9 Disrupted Circadian Rhythms and Neuroendocrine Function in Fertility
- 10 Disrupted Circadian Rhythms and Metabolic Function
- 11 Disrupted Circadian Rhythms, Time Restricted Feeding, and Blood Pressure Regulation
- 12 Disrupted Circadian Rhythms and Immune Function
- 13 Circadian Rhythms and Cardiac Function
- 14 Disrupted Circadian Rhythms and Cancer
- 15 Light Effects across Species in Nature
- 16 Measurement and Analysis of Exposure to Light at Night in Epidemiology
- Index
- References
Summary
Energy intake, utilization, and storage are critical to an animal’s health and fitness. The circadian clock organizes a variety of behavioral, physiological, and molecular processes to anticipate and optimize metabolic function. From behaviors such as the timing of feeding, to molecular interactions with the Clock gene, humans and other animals have evolved to coordinate metabolic processes to a 24-hour day. Thus, when circadian rhythms are disrupted or misaligned, an animal’s ability to anticipate and optimize metabolic processes is compromised. As discussed in this chapter, disruptions to circadian rhythmicity can result in adverse effects on body mass regulation and glucose homeostasis. Because these effects often present in parallel, this chapter organizes its discussion into two sections highlighting work from both clinical and preclinical animal studies. This approach allows one to appreciate the importance of circadian rhythmicity to metabolic wellbeing while introducing mechanistic explanations for how circadian disruption impacts body mass and glucose regulation.
- Type
- Chapter
- Information
- Biological Implications of Circadian DisruptionA Modern Health Challenge, pp. 223 - 237Publisher: Cambridge University PressPrint publication year: 2023
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