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Chapter 2 - Red Blood Cell Disorders

from Section I - Peripheral Blood

Published online by Cambridge University Press:  25 November 2023

By
Sara Graciaa ,
Michele E. Paessler  and
Satheesh Chonat
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Congenital nonimmune hemolytic anemias are disorders of the red blood cells (RBCs) that occur infrequently in children and adults. These disorders can be divided into three categories: disorders affecting RBC metabolism, the RBC membrane, and hemoglobin synthesis. In this chapter, we briefly describe these conditions and the blood smear morphology. Increasing use of ektacytometry, flow cytometry, or the less sensitive osmotic fragility test can help in analyzing RBC membrane disorders. In addition to morphology of RBCs, RBC enzyme and/or genetic testing can be confirmatory for diagnosis.

Type
Chapter
Information
Atlas of Pediatric Hematopathology , pp. 9 - 16
Publisher: Cambridge University Press
Print publication year: 2023

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References

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Caruso, C, Chonat, S. Immune and nonimmune hemolytic anemia. In Kamat, D, Frei-Jones, M, eds. Benign hematologic disorders in children. Cham: Springer; 2021: 51–64. https://doi.org/10.1007/978-3-030-49980-8_4.CrossRefGoogle Scholar
Berentsen, S, Barcellini, W. Autoimmune hemolytic anemias. N Engl J Med. 2021 Oct 7; 385(15): 1407–19.CrossRefGoogle ScholarPubMed

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