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Chapter 11 - Posttransplant Lymphoproliferative Disorder

from Section III - Mature Lymphoid Neoplasm

Published online by Cambridge University Press:  25 November 2023

By
Xiayuan Liang
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Posttransplant lymphoproliferative disorders (PTLDs) comprise a heterogeneous category of lymphoid and plasmacytic proliferations occurring as a result of immunosuppression following solid organ or hematopoietic stem cell transplant [1–5]. PTLDs constitute a spectrum ranging from Epstein-Barr virus (EBV)-driven polyclonal proliferations to monoclonal EBV-positive or EBV-negative proliferations indistinguishable from a subset of B-cell lymphomas, T/natural killer (NK)-cell (less often) lymphomas, or classical Hodgkin lymphoma (cHL) (less often) that occur in immunocompetent individuals [1].

Type
Chapter
Information
Atlas of Pediatric Hematopathology , pp. 98 - 105
Publisher: Cambridge University Press
Print publication year: 2023

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References

Swerdlow, SH, Webber, SA, Chadburn, A, Ferry, LA. Post-transplant lymphoproliferative disorders. In Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Revised 4th ed. Lyon: IARC Press; 2017:453–62.Google Scholar
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Nelson, BP, Nalesnik, MA, Bahler, DW, Locker, J, Fung, JJ, Swerdlow, SH. Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: A distinct entity? Am J Surg Pathol. 2000 Mar 1; 24(3): 375–85.CrossRefGoogle ScholarPubMed
Liu, L, Zhang, X, Feng, S. Epstein-Barr virus-related post-transplantation lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2018 Jul; 24(7): 1341–9.CrossRefGoogle ScholarPubMed
Romero, S, Montoro, J, Guinot, M, Almenar, L, Andreu, R, Balaguer, A, et al. Post-transplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation. Leukemia Lymphoma. 2019 Jan 2; 60(1): 142–50.CrossRefGoogle ScholarPubMed
Vakiani, E, Nandula, SV, Subramaniyam, S, Keller, CE, Alobeid, B, Murty, VV, Bhagat, G. Cytogenetic analysis of B-cell posttransplant lymphoproliferations validates the World Health Organization classification and suggests inclusion of florid follicular hyperplasia as a precursor lesion. Hum Pathol. 2007 Feb 1; 38(2): 315–25.CrossRefGoogle ScholarPubMed
Epperly, R, Ozolek, J, Soltys, K, Cohen, D, Goyal, R, Friehling, E. Treatment of pediatric plasma cell myeloma type post‐transplant lymphoproliferative disorder with modern risk‐directed therapy. Pediatr Blood Cancer. 2018 Oct; 65(10): e27283.CrossRefGoogle ScholarPubMed
Adams, H, Campidelli, C, Dirnhofer, S, Pileri, SA, Tzankov, A. Clinical, phenotypic and genetic similarities and disparities between post-transplant and classical Hodgkin lymphomas with respect to therapeutic targets. Expert Opin Ther Targets. 2009 Oct 1; 13(10): 1137–45.CrossRefGoogle ScholarPubMed

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