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Chapter 16 - Myeloproliferative Neoplasms

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

By
Tracy I. George  and
Karen M. Chisholm
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by a proliferation of one or more of the myeloid lineages [1]. These components include erythroid cells, megakaryocytes, and granulocytes, the latter of which include eosinophils. In many cases, these MPNs are associated with acquired clonal genetic abnormalities involving cytoplasmic or receptor protein tyrosine kinases.

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Chapter
Information
Atlas of Pediatric Hematopathology , pp. 176 - 185
Publisher: Cambridge University Press
Print publication year: 2023

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References

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