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Chapter 15 - Acute Myeloid Leukemia and Related Precursor Neoplasms

from Section IV - Precursor Hematopoietic Neoplasms and Related Neoplasms

Published online by Cambridge University Press:  25 November 2023

By
Virginia Knez ,
Xiayuan Liang ,
Billie Carstens  and
Silvia T Bunting
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
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Summary

Acute myeloid leukemia (AML) is a heterogeneous group of diseases representing a clonal expansion of immature, non-lymphoid, bone marrow-derived cells that involve the bone marrow, blood, and extramedullary tissues. In general, blood or bone marrow blast counts ≥ 20% () are required for diagnosing AML, except for AML with t (8;21) (q22; q22.1), AML with inv (16) (p13.1q22) or t (16;16) (p13.1; q22), and acute promyelocytic leukemia (APML) with PML-RARA [1–4]. The World Health Organization (WHO) classification incorporates morphologic, immunophenotypic, genetic, and clinical features to define prognostically significant disease [3–5].

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Chapter
Information
Atlas of Pediatric Hematopathology , pp. 147 - 175
Publisher: Cambridge University Press
Print publication year: 2023

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References

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