Book contents
- Anxiety Disorders
- Dedication
- Anxiety Disorders
- Copyright page
- Contents
- Contributors
- Foreword
- Preface
- 1 Introduction: the need for interdisciplinary approaches
- Section 1 Evolving concepts of anxiety
- Section 2 Challenges in diagnosing pathological anxiety
- Section 3 Understanding the causes of anxiety
- 13 Current status of research in the genetics of anxiety disorders
- 14 Animal models of anxiety disorders: behavioral and genetic approaches
- 15 Role of the cortex in the regulation of anxiety states
- 16 Learned fear and innate anxiety in rodents and their relevance to human anxiety disorders
- 17 Brain systems underlying anxiety disorders: a view from neuroimaging
- 18 Cognitive–behavioral treatment of anxiety disorders: model and current issues
- 19 The stressor criterion A in posttraumatic stress disorder: issues, evidence, and implications
- 20 Attachment, separation, and anxiety disorders
- 21 Non-human primate models in understanding anxiety
- Section 4 Treatment of anxiety: current status and controversial issues
- Index
14 - Animal models of anxiety disorders: behavioral and genetic approaches
from Section 3 - Understanding the causes of anxiety
Published online by Cambridge University Press: 10 November 2010
Book contents
- Anxiety Disorders
- Dedication
- Anxiety Disorders
- Copyright page
- Contents
- Contributors
- Foreword
- Preface
- 1 Introduction: the need for interdisciplinary approaches
- Section 1 Evolving concepts of anxiety
- Section 2 Challenges in diagnosing pathological anxiety
- Section 3 Understanding the causes of anxiety
- 13 Current status of research in the genetics of anxiety disorders
- 14 Animal models of anxiety disorders: behavioral and genetic approaches
- 15 Role of the cortex in the regulation of anxiety states
- 16 Learned fear and innate anxiety in rodents and their relevance to human anxiety disorders
- 17 Brain systems underlying anxiety disorders: a view from neuroimaging
- 18 Cognitive–behavioral treatment of anxiety disorders: model and current issues
- 19 The stressor criterion A in posttraumatic stress disorder: issues, evidence, and implications
- 20 Attachment, separation, and anxiety disorders
- 21 Non-human primate models in understanding anxiety
- Section 4 Treatment of anxiety: current status and controversial issues
- Index
Summary
This chapter reviews the methods for validating animal models of psychiatric disorders and discusses specific models of anxiety in mice. It demonstrates the importance of understanding the validity of a particular animal model, which assists in determining its clinical relevance in the context of careful interpretation. Currently, two main types of genetically modified mice are used in laboratory: knockout mice or knock-in mice and transgenic mice. The chapter reviews how state-of-the-art transgenic technology can be used to make animal models that allow us to consider the contribution of particular genes to anxiety-like behaviors. Several lines of evidence from human studies have implicated the 5-HT1A receptor in affective disorders. The studies of the 5-HT1A receptor provide an illustrative example of the strengths and weaknesses inherent in using the genetic technologies to investigate the pathophysiology of anxiety.
Keywords
- Type
- Chapter
- Information
- Anxiety DisordersTheory, Research and Clinical Perspectives, pp. 156 - 167Publisher: Cambridge University PressPrint publication year: 2010
- 1
- Cited by