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9 - Preclinical Longitudinal In Vivo Biomarker Platform for Alzheimer’s Disease Drug Discovery

from Section 2 - Non-clinical Assessment of Alzheimer’s Disease Candidate Drugs

Published online by Cambridge University Press:  03 March 2022

By
Min Su Kang ,
Eduardo R. Zimmer ,
Julie Ottoy ,
Monica Shin ,
Marcel Seungsu Woo ,
Arturo Aliaga ,
Gassan Massarweh ,
A. Claudio Cuello ,
Serge Gauthier  and
Pedro Rosa-Neto
Edited by
Jeffrey Cummings ,
Jefferson Kinney  and
Howard Fillit
Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

The incorporation of target engagement, efficacy, and imaging abnormalities biomarkers on preclinical (animal) drug development brings the promise of accelerating drug development. In this chapter, we will highlight innovative methodological considerations that will bring greater predictive power relative to the traditional approaches in the preclinical stage of drug discovery. First, we discuss various animal models used in Alzheimer’s disease research and important aspects to consider when choosing the appropriate model to test a novel therapeutic intervention. Second, compared to the traditional histological methods, utilizing in vivo biomarkers in preclinical assessment allows quantifying disease pathophysiology with complex longitudinal designs. We discuss the feasibility and implications of longitudinal study designs and how the same in vivo biomarkers used in human clinical trials can be implemented to evaluate the preclinical development stages. Lastly, we discuss why the incorporation of methods from human clinical trials can advance the preclinical phases of drug discovery.

Keywords

Alzheimer’s diseasedrug discoverypreclinical longitudinal studiesanimal modelsin vivo biomarkersPETMRIFluidsCSFplasma
Type
Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
 , pp. 106 - 122
Publisher: Cambridge University Press
Print publication year: 2022

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