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10 - Biobanking and Biomarkers in the Alzheimer’s Disease Drug-Development Ecosystem

from Section 2 - Non-clinical Assessment of Alzheimer’s Disease Candidate Drugs

Published online by Cambridge University Press:  03 March 2022

Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

Biobanks and biomarker discovery workflows have grown to be an essential piece of clinical trial research to advance candidate therapeutics. While initially biobanks were established for safety and tolerability examinations they now provide data on inclusion measures for clinical trials, as well as numerous outcome measures that inform on target engagement to disease-modifying effects. This process is complex as there is tremendous need for standardization of everything from sample collection and storage to reproducibility of experimental data. With biomarker discovery capabilities advancing at a rapid pace novel techniques in various samples have also become part of the biobank workflow. In this chapter we highlight some of the prevailing considerations in biobanking and biomarker discovery. We also highlight the approaches that are emerging as the next steps in biomarker discovery in Alzheimer’s disease clinical trial research.

Type
Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
, pp. 123 - 134
Publisher: Cambridge University Press
Print publication year: 2022

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