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15 - ATRI and ACTC: Academic Programs to Accelerate Alzheimer’s Disease Drug Development

from Section 3 - Alzheimer’s Disease Clinical Trials

Published online by Cambridge University Press:  03 March 2022

By
Paul S. Aisen ,
Rema Raman ,
Michael S. Rafii ,
Reisa A. Sperling  and
Ronald C. Petersen
Edited by
Jeffrey Cummings ,
Jefferson Kinney  and
Howard Fillit
Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

Academic investigators have played key roles in Alzheimer’s disease drug development. This work has been highly collaborative, with innovations in trial design, population characteristics, outcome measures, biomarker utilization and regulatory pathways arising from interactions among academics, industry scientists, regulators, and other stakeholders. The National Institute on Aging (NIA) has funded much of this work, along with the Alzheimer’s Association and other philanthropic organizations. The NIA Alzheimer’s Clinical Trials Consortium (ACTC) supports a nationwide infrastructure to continue academic efforts on trial methodology and the implementation of innovative studies in age-related neurodegenerative disorders. ACTC, with the University of Southern California, Harvard University and the Mayo Clinic, expert trialists from across the country and 35 primary trial sites, conducts a number of multicenter randomized controlled trials. Public-private partnerships are encouraged. Additional innovations include a focus on diversity and inclusion in trial recruitment, involvement of research participants in guiding trial design, and training the next generation of trialists.

Keywords

Alzheimer’s diseasetherapeutic trialsclinical trial consortiumbiomarkersoutcome measuresbiostatisticsrecruitment
Type
Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
 , pp. 177 - 189
Publisher: Cambridge University Press
Print publication year: 2022

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