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29 - Alzheimer’s Disease Clinical Trial Study Partners

from Section 3 - Alzheimer’s Disease Clinical Trials

Published online by Cambridge University Press:  03 March 2022

By
Joshua Grill
Edited by
Jeffrey Cummings ,
Jefferson Kinney  and
Howard Fillit
Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

Alzheimer’s disease (AD) clinical trials now include patients living with dementia, patients living with mild cognitive impairment or prodromal Alzheimer’s disease (AD), and patients with no cognitive impairment but biomarker evidence of preclinical disease. Each type of AD trial requires participants to enroll with a person they know well who can participate with them, a study partner. Study partners are essential to AD trial success. They are heavily involved in enrollment decisions, they are vital to trial protocol compliance, and they serve as informants for outcome measurements that are used to determine drug efficacy. This chapter reviews the essential role of study partners and the evidence available to instruct the field about how best to incorporate and potentially improve the design and conduct of trials as it relates to study partners.

Keywords

Caregiverpartnerinformantrecruitmentretentiondropout
Type
Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
 , pp. 333 - 342
Publisher: Cambridge University Press
Print publication year: 2022

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