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Chapter 12 - Myeloproliferative Neoplasms (MPNs)

from Section IV - Neoplastic Disorders of Bone Marrow

Published online by Cambridge University Press:  25 January 2024

By
Bradford Siegele
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Chronic myeloid leukemia (CML), BCR-ABL1+, is a clonal myeloproliferative neoplasm (MPN) with a hyperabundance of granulocyte forms, defined by the presence of the BCR-ABL1 fusion gene, most frequently due to the chromosomal translocation t(9;22)(q34.1;q11.2) resulting in the Philadelphia (Ph) chromosome.

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Chapter
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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 130 - 147
Publisher: Cambridge University Press
Print publication year: 2024

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