Bone Marrow Failure Syndromes

doi:10.1017/9781009105002.004

Chapter 4 - Bone Marrow Failure Syndromes

from Section II - Non-Neoplastic Hematologic Disorders of Blood and Bone Marrow

Published online by Cambridge University Press: 25 January 2024

Edited by

Bradford Siegele and

Xiayuan Liang: Affiliation:
Children’s Hospital of Colorado
Bradford Siegele: Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic: Affiliation:
Cincinnati Childrens Hospital Medicine Center

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Summary

Bone marrow failure syndromes comprise a heterogeneous group of disorders that may be inherited or acquired; may be static or progressive; and may affect any one hematopoietic lineage individually, multiple lineages, or all lineages collectively. The unifying feature consists of the failure of the bone marrow to supply the body with normal quantities of the mature forms of any of the three hematopoietic-lineage elements. Although bone marrow failure syndromes may engender a predisposition to the development of associated malignancies, and primary neoplastic processes involving the bone marrow and peripheral blood may meet the criteria of impaired hematopoiesis, discussion of neoplastic processes associated with cytopenias will be largely covered elsewhere.

Type: Chapter
Information: Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 25 - 51

DOI: https://doi.org/10.1017/9781009105002.004 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2024

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