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Chapter 17 - Acute Leukemia of Ambiguous Lineage

from Section IV - Neoplastic Disorders of Bone Marrow

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang  and
Silvia Tse Bunting
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Acute leukemias of ambiguous lineage (ALALs) are leukemias that show no clear evidence of differentiation along a single lineage [1]. ALALs are rare and comprise 2–3% of acute leukemia (0.35 cases per 1 million person-years) [1–5]. They occur in both children and adults, with a male predominance [1,2,4].

ALALs represent a heterogeneous group of diseases. Cases of ALAL mostly fall into two broad categories: acute undifferentiated leukemia (AUL) and mixed-phenotype acute leukemia (MPAL) [1–5]. The current classification is mainly based on immunophenotypes and genetic features outlined in World Health Organization (WHO) classification system (Table 17.1) [1,2,5,6].

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Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 199 - 207
Publisher: Cambridge University Press
Print publication year: 2024

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References

Borowitz, MJ, Bene, MC, Harris, NL, et al. Acute leukemias of ambiguous lineage. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissues. Rev. 4th ed. Lyon, France:IARC Press; 2017:180–7.Google Scholar
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