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Chapter B1 - Mass and charge

from Part B - Mass spectrometry

Published online by Cambridge University Press:  05 November 2012

Igor N. Serdyuk ,
Nathan R. Zaccai  and
Joseph Zaccai
Igor N. Serdyuk
Affiliation:
Institute of Protein Research, Moscow
Nathan R. Zaccai
Affiliation:
University of Bristol
Joseph Zaccai
Affiliation:
Institut de Biologie Structurale, Grenoble
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Summary

Historical review

1897

J. J. Thomson made the first measurement of the mass-to-charge ratio of elementary particle ‘corpuscles’, which later became known as electrons. This can fairly be considered as the birth of mass spectrometry.

1918–1919

A. Dempster and F. Aston developed the first mass spectrographs. Photographic plate was used as the array detector. The instruments were used for isotopic relative abundance measurements.

1951

W. Pauli and H. Steinwedel described the development of a quadrupole mass spectrometer. The application of superimposed radio-frequency and constant potentials between four parallel rods acted as a mass separator in which only ions within a particular mass range perform oscillations of constant amplitude and are collected at the far end of the analyser.

1959

K. Biemann was the first to apply electron ionisation mass spectrometry to the analysis of peptides. Later it was shown that for sequence determination, peptides had to be derivatized prior to analysis by a direct probe.

1968–1970

M. Dole was the first to bring synthetic and natural polymers into the gas phase at atmospheric pressure. This was done by spraying a sample solution from a small tube into a strong electric field in the presence of a flow of warm nitrogen, to assist desolvation. First experiments on lysozyme demonstrated the phenomenon of multiple charging.

1974

D. Torgerson introduced plasma desorption mass spectrometry. This technique uses 252Cf fission fragments to desorb large molecules from a target.

Type
Chapter
Information
Methods in Molecular Biophysics
Structure, Dynamics, Function
 , pp. 111 - 135
Publisher: Cambridge University Press
Print publication year: 2007

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References

Griffiths, I. W. (1997). J. J. Thomson – the centenary of his discovery of the electron and his invention of mass spectrometry. Rapid Commun. Mass Spectr., 11, 2–16.3.0.CO;2-V>CrossRefGoogle Scholar
Comisarow, M. B., and Marshall, A. G. (1996). The early development of Fourier transform ion cyclotron resonance (FT-ICR) spectroscopy. J. Mass Spectr., 31, 581–5.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Smith, D. R., Loo, J. A., Loo, R. R. O., Busman, M., and Udseth, H. R. (1991). Principles and practice of electrospray ionization – mass spectrometry for large polypeptides and proteins. Mass Spectr. Rev., 10, 359–451.CrossRefGoogle Scholar
Muddiman, D. C., Gusev, A. I., and Hercules, D. M. (1995). Application of secondary ion and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for the quantitative analysis of biological molecules. Mass Spectr. Rev., 14, 383–429.CrossRefGoogle Scholar
Gordon, D. B. (2000). Mass spectrometric techniques. In Principles and Techniques of Practical Biochemistry, Chapter 11, eds. Wilson, K. and Walker, J.. Cambridge: Cambridge University Press.Google Scholar
Caprioli, R. M., and Suter, M. J. F.Mass spectrometry. Chapter 4 in Introduction to Biophysical Methods for Protein and Nucleic Research, Academic Press.
Amster, I. J. (1996). Fourier transform mass spectrometry. J. Mass Spectr., 31, 1325–1337.3.0.CO;2-W>CrossRefGoogle Scholar
Hofmann, E. (1996). Tandem mass spectrometry: a primer. J. Mass Spectr., 31, 129–37.3.0.CO;2-T>CrossRefGoogle Scholar
Dienes, T., Pastor, J. S., et al. (1996). Fourier transform mass spectrometry – advancing years (1992–mid 1996). Mass Spectr. Rev., 15, 163–211.3.0.CO;2-G>CrossRefGoogle Scholar
Guilhaus, M., Mlynski, V. and Selbi, D. (1997). Perfect timing: time-of-flight mass spectrometry. Rapid Commun. Mass Spectr., 11, 951–962.3.0.CO;2-H>CrossRefGoogle Scholar
Belov, M. E., Gorshkov, M. V., Udeseth, H. R., Anderson, G. A. and Smith, R. D. (2000). Zeptomole-sensititivity electrospray ionization – Fourier transform ion cyclotron resonance mass spectrometry proteins. Anal. Chem., 72, 2271–2279.CrossRefGoogle ScholarPubMed
Griffiths, I. W. (1997). J. J. Thomson – the centenary of his discovery of the electron and his invention of mass spectrometry. Rapid Commun. Mass Spectr., 11, 2–16.3.0.CO;2-V>CrossRefGoogle Scholar
Comisarow, M. B., and Marshall, A. G. (1996). The early development of Fourier transform ion cyclotron resonance (FT-ICR) spectroscopy. J. Mass Spectr., 31, 581–5.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Smith, D. R., Loo, J. A., Loo, R. R. O., Busman, M., and Udseth, H. R. (1991). Principles and practice of electrospray ionization – mass spectrometry for large polypeptides and proteins. Mass Spectr. Rev., 10, 359–451.CrossRefGoogle Scholar
Muddiman, D. C., Gusev, A. I., and Hercules, D. M. (1995). Application of secondary ion and matrix-assisted laser desorption-ionization time-of-flight mass spectrometry for the quantitative analysis of biological molecules. Mass Spectr. Rev., 14, 383–429.CrossRefGoogle Scholar
Gordon, D. B. (2000). Mass spectrometric techniques. In Principles and Techniques of Practical Biochemistry, Chapter 11, eds. Wilson, K. and Walker, J.. Cambridge: Cambridge University Press.Google Scholar
Caprioli, R. M., and Suter, M. J. F.Mass spectrometry. Chapter 4 in Introduction to Biophysical Methods for Protein and Nucleic Research, Academic Press.
Amster, I. J. (1996). Fourier transform mass spectrometry. J. Mass Spectr., 31, 1325–1337.3.0.CO;2-W>CrossRefGoogle Scholar
Hofmann, E. (1996). Tandem mass spectrometry: a primer. J. Mass Spectr., 31, 129–37.3.0.CO;2-T>CrossRefGoogle Scholar
Dienes, T., Pastor, J. S., et al. (1996). Fourier transform mass spectrometry – advancing years (1992–mid 1996). Mass Spectr. Rev., 15, 163–211.3.0.CO;2-G>CrossRefGoogle Scholar
Guilhaus, M., Mlynski, V. and Selbi, D. (1997). Perfect timing: time-of-flight mass spectrometry. Rapid Commun. Mass Spectr., 11, 951–962.3.0.CO;2-H>CrossRefGoogle Scholar
Belov, M. E., Gorshkov, M. V., Udeseth, H. R., Anderson, G. A. and Smith, R. D. (2000). Zeptomole-sensititivity electrospray ionization – Fourier transform ion cyclotron resonance mass spectrometry proteins. Anal. Chem., 72, 2271–2279.CrossRefGoogle ScholarPubMed

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  • Mass and charge
  • Igor N. Serdyuk, Institute of Protein Research, Moscow, Nathan R. Zaccai, University of Bristol, Joseph Zaccai, Institut de Biologie Structurale, Grenoble
  • Book: Methods in Molecular Biophysics
  • Online publication: 05 November 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511811166.008
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  • Mass and charge
  • Igor N. Serdyuk, Institute of Protein Research, Moscow, Nathan R. Zaccai, University of Bristol, Joseph Zaccai, Institut de Biologie Structurale, Grenoble
  • Book: Methods in Molecular Biophysics
  • Online publication: 05 November 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511811166.008
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Mass and charge
  • Igor N. Serdyuk, Institute of Protein Research, Moscow, Nathan R. Zaccai, University of Bristol, Joseph Zaccai, Institut de Biologie Structurale, Grenoble
  • Book: Methods in Molecular Biophysics
  • Online publication: 05 November 2012
  • Chapter DOI: https://doi.org/10.1017/CBO9780511811166.008
Available formats
×