Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-13T09:26:11.307Z Has data issue: false hasContentIssue false

Chapter 5 - The Oocyte’s Role in Embryo Development

Published online by Cambridge University Press:  26 April 2023

Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
Get access

Summary

For embryo development to proceed, the female gamete or oocyte must acquire and express nuclear and cytoplasmic determinants prior to, during, and following fertilization. The biological principles acquired during the process of oogenesis, involving hypertrophy, reorganization, and storage of maternal factors, must be coupled temporally with a phase of “maturation” occurring at the time of ovulation. In human ARTs, controlled ovarian stimulation (COS) is used to sustain the final stages of oogenesis with “maturation” being elicited by pharmacologically triggering ovulation. This chapter focuses on the maturation process in mammalian oocytes from a biological and clinical point of view emphasizing the role of maternal determinants in initiating and sustaining development of the embryo.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Coticchio, G, Albertini, DF, De Santis, L, editors. Oogenesis. New York: Springer; 2013.Google Scholar
Albertini, DF. The mammalian oocyte. In: Plant, T, Zeleznik, A, editors. Knobil and Neill’s Physiology of Reproduction. 4th ed. New York: Elsevier; 2015. p. 5997.CrossRefGoogle Scholar
Vassena, R, members of the EBART group. Evidence-based medicine in ART. Hum Reprod. 2017;32(1):256.Google ScholarPubMed
De los Santos, MJ, Apter, S, Coticchio, G, Debrock, S, Lundin, K, et al. Revised guidelines for good practice in IVF laboratories (2015). Hum Reprod. 2016;31(4):685–6.Google Scholar
Krisher, RL. The effect of oocyte quality on development. J Anim Sci. 2004;82(E-Suppl.):E14–23.Google ScholarPubMed
Weghofer, A, Kushnir, VA, Darmon, SK, Jafri, H, Lazzaroni-Tealdi, E, Zhang, L, et al. Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI). PLoS ONE. 2019;14(10):e0222390.CrossRefGoogle ScholarPubMed
Conti, M, Franciosi, F. Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events. Hum Reprod Update. 2018;24(3):245–66.CrossRefGoogle ScholarPubMed
Da Broi, MG, Giorgi, VSI, Wang, F, Keefe, DL, Albertini, D, Navarro, PA. Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications. J Assist Reprod Genet. 2018;35(5):735–51.CrossRefGoogle ScholarPubMed
Latham, KE. Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes. Cell Tissue Res. 2016;363(1):159–67.Google Scholar
Combelles, CMH, Rawe, VY. Determinants of oocyte quality: impact on in vitro fertilization failures. In: Coticchio, G, Albertini, DF, De Santis, L, editors. Oogenesis. New York: Springer; 2013. p. 307–27.Google Scholar
Combelles, CM, Kearns, WG, Fox, JH, Racowsky, C. Cellular and genetic analysis of oocytes and embryos in a human case of spontaneous oocyte activation. Hum Reprod. 2011;26(3):545–52.Google Scholar
Dal Canto, M, Guglielmo, MC, Mignini Renzini, M, Fadini, R, Moutier, C, Merola, M, et al. Dysmorphic patterns are associated with cytoskeletal alterations in human oocytes. Hum Reprod. 2017;32(4):750–7.Google ScholarPubMed
McGinnis, LK, Albertini, DF. Dynamics of protein phosphorylation during meiotic maturation. J Assist Reprod Genet. 2010;27(4):169–82.Google Scholar
Bebbere, D, Masala, L, Albertini, DF, Ledda, S. The subcortical maternal complex: multiple functions for one biological structure? J Assist Reprod Genet. 2016;33(11):1431–8.Google Scholar
Feng, R, Yan, Z, Li, B, Yu, M, Sang, Q, Tian, G, et al. Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos. J Med Genet. 2016;53(10):662–71.CrossRefGoogle Scholar
Andersen, CY, Kelsey, T, Mamsen, LS, Vuong, LN. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin. Fertil Steril. 2020;114(2):200–8.CrossRefGoogle ScholarPubMed
Zaninovic, N, Nohales, M, Zhan, Q, de Los Santos, ZMJ, Sierra, J, Rosenwaks, Z, et al. A comparison of morphokinetic markers predicting blastocyst formation and implantation potential from two large clinical data sets. J Assist Reprod Genet. 2019;36(4):637–46.CrossRefGoogle ScholarPubMed
Simopoulou, M, Sfakianoudis, K, Maziotis, E, Antoniou, N, Rapani, A, Anifandis, G, et al. Are computational applications the “crystal ball” in the IVF laboratory? The evolution from mathematics to artificial intelligence. J Assist Reprod Genet. 2018;35(9):1545–57.Google Scholar
Maziotis, E, Sfakianoudis, K, Giannelou, P, Grigoriadis, S, Rapani, A, Tsioulou, P, et al. Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome. Sci Rep. 2020;10(1):19325.CrossRefGoogle Scholar
Vuong, LN, Le, AH, Ho, VNA, Pham, TD, Sanchez, F, Romero, S, et al. Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome. J Assist Reprod Genet. 2020;37(2):347–57.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×