Book contents
- Manual of Embryo Selection in Human Assisted Reproduction
- Manual of Embryo Selection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 Introduction
- Chapter 2 Embryo Developmental Programming
- Chapter 3 Embryo–Maternal Interactions
- Chapter 4 The Sperm’s Role in Embryo Development
- Chapter 5 The Oocyte’s Role in Embryo Development
- Chapter 6 The Laboratory’s Role in Embryo Development
- Chapter 7 Handling of Gametes and Embryos
- Chapter 8 Noninvasive Morphological Selection of Oocytes
- Chapter 9 Prospects for Bioenergetics for Embryo Selection
- Chapter 10 Static Morphological Assessment for Embryo Selection
- Chapter 11 Dynamic Morphological Assessment for Embryo Selection
- Chapter 12 Noninvasive Analysis of Embryo Nutrient Utilization for Embryo Selection
- Chapter 13 Genomics for Embryo Selection
- Chapter 14 Biopsy Techniques from Polar Body to Blastocyst
- Chapter 15 Cell-Free DNA Analysis for PGT-A
- Chapter 16 What Science May Come for Embryo Selection?
- Epilogue
- Index
- References
Chapter 5 - The Oocyte’s Role in Embryo Development
Published online by Cambridge University Press: 26 April 2023
- Manual of Embryo Selection in Human Assisted Reproduction
- Manual of Embryo Selection in Human Assisted Reproduction
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 Introduction
- Chapter 2 Embryo Developmental Programming
- Chapter 3 Embryo–Maternal Interactions
- Chapter 4 The Sperm’s Role in Embryo Development
- Chapter 5 The Oocyte’s Role in Embryo Development
- Chapter 6 The Laboratory’s Role in Embryo Development
- Chapter 7 Handling of Gametes and Embryos
- Chapter 8 Noninvasive Morphological Selection of Oocytes
- Chapter 9 Prospects for Bioenergetics for Embryo Selection
- Chapter 10 Static Morphological Assessment for Embryo Selection
- Chapter 11 Dynamic Morphological Assessment for Embryo Selection
- Chapter 12 Noninvasive Analysis of Embryo Nutrient Utilization for Embryo Selection
- Chapter 13 Genomics for Embryo Selection
- Chapter 14 Biopsy Techniques from Polar Body to Blastocyst
- Chapter 15 Cell-Free DNA Analysis for PGT-A
- Chapter 16 What Science May Come for Embryo Selection?
- Epilogue
- Index
- References
Summary
For embryo development to proceed, the female gamete or oocyte must acquire and express nuclear and cytoplasmic determinants prior to, during, and following fertilization. The biological principles acquired during the process of oogenesis, involving hypertrophy, reorganization, and storage of maternal factors, must be coupled temporally with a phase of “maturation” occurring at the time of ovulation. In human ARTs, controlled ovarian stimulation (COS) is used to sustain the final stages of oogenesis with “maturation” being elicited by pharmacologically triggering ovulation. This chapter focuses on the maturation process in mammalian oocytes from a biological and clinical point of view emphasizing the role of maternal determinants in initiating and sustaining development of the embryo.
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- Publisher: Cambridge University PressPrint publication year: 2023