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Published online by Cambridge University Press: 05 June 2012
The cover contains images that together represent the broad scope of modern biomechanics. The figures are as follows:
Main image: A fluorescent immunohistochemical image of an endothelial cell isolated from the surface of a pig aortic heart valve and grown in culture. Within the cell, the nucleus is stained blue and vimentin filaments are stained green. Vimentin is an intermediate filament protein of the cellular cytoskeleton that plays an important role in cellular mechanics.
Left top: An intermediate stage from a simulation of the forced unfolding of repeats 4 and 5 of chain A of the protein filamin. Filamin is an actin cross-linking protein and therefore plays a role in the biomechanics of the cytoskeleton. The simulation was based on the crystal structure of part of filamin [1], and was carried out in NAMD [2] and visualized using the VMD package [3]. (Image courtesy of Mr. Blake Charlebois.)
Left middle: A sketch by the Swiss anatomist Hermann von Meyer of the orientation of trabecular bone in the proximal human femur. This sketch was accompanied in the original article by a sketch of the principal stress trajectories in a crane having a shape similar to the femur. Together these sketches are believed to have inspired “Wolff's Law” of bone remodelling. From [4].
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