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12 - Anatomical, physiological, and pharmacological properties underlying hippocampal sensorimotor integration

Published online by Cambridge University Press:  14 August 2009

By
Brian H. Bland
Edited by
Christian Holscher  and
Matthias Munk
Christian Holscher
Affiliation:
University of Ulster
Matthias Munk
Affiliation:
Max-Planck-Institut für biologische Kybernetik, Tübingen
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Summary

The cellular basis of theta-band oscillation and synchrony

The limbic cortex represents multiple synchronizing systems (Bland and Colom, 1993). Populations of cells in these structures display membrane potential oscillations as a result of intrinsic properties of membrane currents. These cells also receive inputs from other cells in the same structure and inputs from cells extrinsic to the structure, many of the latter from nuclei contributing to the ascending brainstem hippocampal synchronizing pathways. Theta-band oscillation and synchrony in the hippocampal formation (HPC) and related limbic structures is recorded as an extracellular field potential consisting of a sinusoidal-like waveform with an amplitude up to 2 mV and a narrow band frequency range of 3–12 Hz in mammals. The asynchronous activity termed large-amplitude irregular activity (LIA) is an irregular waveform with a broadband frequency range of 0.5–25 Hz (Leung et al., 1982). Kramis et al. (1975) were the first formally to propose the existence of two types of hippocampal theta activity, in both the rabbit and the rat (see review by Bland, 1986). One type was termed atropine-sensitive theta, since it were abolished by the administration of atropine sulfate. Atropine-sensitive theta occurred during immobility in rabbits in the normal state and occurred in both rabbits and rats during immobility produced by ethyl ether or urethane treatment. The other type of theta was termed atropine-resistant, since it was not sensitive to treatment with atropine sulfate but was abolished by anesthetics.

Type
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Information
Information Processing by Neuronal Populations , pp. 283 - 325
Publisher: Cambridge University Press
Print publication year: 2008

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