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14 - Information resources: learning about flu viruses

Published online by Cambridge University Press:  05 August 2012

Tore Samuelsson
Tore Samuelsson
Affiliation:
Göteborgs Universitet, Sweden
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Summary

All science is either physics or stamp collecting.

(Ernest Rutherford)

The 1918 flu pandemic, also referred to as the Spanish flu, was a devastating infectious disease. It is estimated that 50 million people, about 3% of the world's population at the time, died of the disease. About 500 million people were infected. The causative agent was an influenza virus. In this chapter we will learn more about these viruses. We will make use of highly significant molecular biology databases and bioinformatics tools. These are useful not only for learning about influenza viruses, but are widely used to explore just about any topic in biology.

Short history of sequence databases

A vast amount of information is collected by projects around the world designed to characterize genomes, genes and proteins. The development with respect to DNA sequencing is particularly remarkable. One important task in bioinformatics is to store all of this information in databases and, importantly, to make it available to the scientific community for downloading and analysis. Numerous dedicated individuals working on database projects are the unsung heroes of bioinformatics and molecular biology (see also the quotation on stamp collecting above).

Type
Chapter
Information
Genomics and Bioinformatics
An Introduction to Programming Tools for Life Scientists
 , pp. 173 - 197
Publisher: Cambridge University Press
Print publication year: 2012

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References

Andersen, J. S. 1984 Nucleotide Sequences 1984: A Compilation from the Genbank and EMBL Data Libraries – A Special Supplement to Nucleic Acids Research Oxford IRL Press Google Scholar
Armstrong, J. 1985 Nucleotide Sequences 1985: A Compilation from the GenBank and EMBL Data Libraries – A Special Supplement to Nucleic Acids Research Oxford and Washington, DC IRL Press Google Scholar
Baxevanis, A. D. 2008
Benson, D. A. Karsch-Mizrachi, I. Lipman, D. J. Ostell, J. Sayers, E. W. 2010 GenBank Nucleic Acids Res 36 D25 CrossRefGoogle ScholarPubMed
Bilofsky, H. S. Burks, C. Fickett, J. W. 1986 The GenBank genetic sequence databank Nucleic Acids Res 14 1 CrossRefGoogle ScholarPubMed
Brockwell-Staats, C. Webster, R. G. Webby, R. J. 2009 Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza A (H1N1) Influenza Other Respi Viruses 3 207 CrossRefGoogle Scholar
Dayhoff, M. O. 1965 Atlas of Protein Sequence and Structure Silver Spring, MD National Biomedical Research Foundation Google Scholar
Fiers, W. Contreras, R. Duerinck, F. 1976 Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene Nature 260 500 CrossRefGoogle ScholarPubMed
Garten, R. J. Davis, C. T. Russell, C. A. 2009 Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans Science 325 197 CrossRefGoogle ScholarPubMed
Holley, R. W. Apgar, J. Everett, G. A. 1965 Structure of a ribonucleic acid Science 147 1462 CrossRefGoogle ScholarPubMed
International Human Genome Sequencing Consortium 2004 Finishing the euchromatic sequence of the human genome Nature 431 931 CrossRefGoogle Scholar
Lander, E. S. Linton, L. M. Birren, B. 2001 Initial sequencing and analysis of the human genome Nature 409 860 Google ScholarPubMed
National Biomedical Research Foundation Eck, R. V Dayhoff, M. O 1966 Atlas of Protein Sequence and Structure, 1966 Silver Spring MD, National Biomedical Research Foundation Google Scholar
Smith, G. J. Vijaykrishna, D. Bahl, J. 2009 Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic Nature 459 1122 CrossRefGoogle ScholarPubMed
Strasser, B. J. 2009 Collecting, comparing, and computing sequences: the making of Margaret O. Dayhoff's , 1954–1965 J Hist Biol 43 623 CrossRefGoogle Scholar
Stretton, A. O. 2002 The first sequence: Fred Sanger and insulin Genetics 162 527 Google ScholarPubMed
Venter, J. C. Adams, M. D. Myers, E. W. 2001 The sequence of the human genome Science 291 1304 CrossRefGoogle ScholarPubMed

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