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Case 20 - Treatment-resistant depression and opioid dependence

Published online by Cambridge University Press:  19 October 2021

By
Kevin Simonson  and
Alexander H. Truong
Edited by
Takesha Cooper ,
Gerald Maguire  and
Stephen Stahl
Takesha Cooper
Affiliation:
University of California, Riverside
Gerald Maguire
Affiliation:
University of California, Riverside
Stephen Stahl
Affiliation:
University of California, San Diego
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Summary

Pretest self-assessment question (answer at the end of the case)

Type
Chapter
Information
Case Studies: Stahl's Essential Psychopharmacology , pp. 227 - 236
Publisher: Cambridge University Press
Print publication year: 2021

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References

Berman, RM, Cappiello, A, Anand, A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000; 47:351–4. https://doi.org/10.1016/s0006-3223(99)00230-9CrossRefGoogle ScholarPubMed
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Duman, R, Li, N, Liu, R, et al. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 2012; 62:35–41. https://doi.org/10.1016/j.neuropharm.2011.08.044CrossRefGoogle ScholarPubMed
Heifets, BD, Williams, NR, Blasey, C, et al. Interpreting ketamine’s opioid receptor dependent effect: response to Sanacora. Am J Psychiatry 2019; 176:249–50. https://doi.org/10.1176/appi.ajp.2018.18091061rCrossRefGoogle ScholarPubMed
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Raehal, KM, Lowery, JJ, Bhamidipati, CM, et al. In vivo characterization of 6β-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. J Pharmacol Exp Ther 2005; 313:1150–62. https://doi.org/10.1124/jpet.104.082966CrossRefGoogle ScholarPubMed
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Scheuing, L, Chiu, C-T, Liao, H-M, Chuang, D-M. Antidepressant mechanism of ketamine: perspective from preclinical studies. Front Neurosci 2015; 9:249. https://doi.org/10.3389/fnins.2015.00249CrossRefGoogle ScholarPubMed
Shader, R. Antagonists, inverse agonists, and protagonists. J Clin Psychopharmacol 2003; 23:321–2. https://doi.org/10.1097/01.jcp.0000087502.38434.6cCrossRefGoogle ScholarPubMed
Stahl, SM. Stahl’s Essential Psychopharmacology, 4th edn. New York, NY: Cambridge University Press, 2013.Google Scholar
Stahl, SM. Stahl’s Essential Psychopharmacology: The Prescriber’s Guide, 6th edn. Cambridge, UK: Cambridge University Press, 2017.Google Scholar
Wang, M, Kaplin, A. Explaining naltrexone’s interference with ketamine’s antidepressant effect. Am J Psychiatry 2019; 176:410–11. https://doi.org/10.1176/appi.ajp.2019.19010044CrossRefGoogle ScholarPubMed
Williams, NR, Heifets, BD, Blasey, C, et al. Attenuation of antidepressant effects of ketamine by opioid receptor antagonism. Am J Psychiatry 2018; 175:1205–15.CrossRefGoogle ScholarPubMed

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