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13 - Circadian Rhythms and Cardiac Function

Published online by Cambridge University Press:  07 October 2023

By
Leandro C. Brito ,
Saurabh S. Thosar  and
Matthew P. Butler
Edited by
Laura K. Fonken  and
Randy J. Nelson
Laura K. Fonken
Affiliation:
University of Texas, Austin
Randy J. Nelson
Affiliation:
West Virginia University
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Summary

Circadian clocks in all tissues confer temporal organization to the physiology and behavior of organisms. Rhythms of the cardiovascular system have been scrutinized because of the morning peak of adverse cardiovascular events and because night and rotating shift work have been associated with heart disease and biomarkers of elevated cardiometabolic risk. Animal models support the important role that the clock plays in the heart. External disruptions such as jetlag and internal disruptions such as loss of clock function contribute to poor heart health. In this chapter, we review key findings from animal models of circadian disruption and from experiments in humans designed to isolate the effects of the circadian clock on cardiovascular physiology.

Keywords

chronobiology disordershift work schedulebiological clockscardiovascular diseasesheart disease risk factors
Type
Chapter
Information
Biological Implications of Circadian Disruption
A Modern Health Challenge
 , pp. 285 - 309
Publisher: Cambridge University Press
Print publication year: 2023

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