Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-27T21:59:45.588Z Has data issue: false hasContentIssue false

Chapter 6 - Normal Bone Marrow Components in Pediatric Patients

from Section II - Normal and Non-neoplastic Hematolymphoid Diseases

Published online by Cambridge University Press:  25 November 2023

By
Karen M. Chisholm  and
Gerald Wertheim
Edited by
Silvia Tse Bunting ,
Xiayuan Liang ,
Michele E. Paessler  and
Satheesh Chonat
Silvia Tse Bunting
Affiliation:
Cleveland Clinic Florida Weston
Xiayuan Liang
Affiliation:
University of Colorado
Michele E. Paessler
Affiliation:
University of Pennsylvania School of Medicine
Satheesh Chonat
Affiliation:
Emory University, Atlanta
Get access

Summary

Bone marrow studies may be requested to evaluate for hematopoietic or solid neoplasms, or to help elucidate the etiology of abnormalities in the peripheral blood or lesions identified by imaging studies. These bone marrow specimens may include aspirate smears, clot sections, particle preparations, core touch preparations, and core biopsies. These specimens (preferably aspirates) can also be used for ancillary studies such as flow cytometry, cytogenetics, and molecular analysis to supplement the morphologic picture.

Type
Chapter
Information
Atlas of Pediatric Hematopathology , pp. 42 - 51
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Greer, JP, Arber, DA, Glader, B, List, AF, Means, RT, Paraskevas, F, et al. Wintrobe’s clinical hematology. 13th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014.Google Scholar
Bain, BJ, Clark, DM, Lampert, IA, Wilkins, BS. Bone marrow pathology. 3rd ed. Oxford: Blackwell Science; 2001.CrossRefGoogle Scholar
Foucar, K, Reichard, K, Czuchlewski, D. Bone marrow pathology. 4th ed. Hong Kong: American Society for Clinical Pathology Press; 2020.Google ScholarPubMed
Foucar, K, Viswanatha, DS, Wilson, CS. Non-neoplastic disorders of bone marrow. Atlas of nontumor pathology. Washington, DC: American Registry of Pathology; 2008.Google Scholar
Friebert, SE, Shepardson, LB, Shurin, SB, Rosenthal, GE, Rosenthal, NS. Pediatric bone marrow cellularity: Are we expecting too much? J Pediatr Hematol Oncol. 1998; 20(5): 439–43.CrossRefGoogle ScholarPubMed
Hartsock, RJ, Smith, EB, Petty, CS. Normal variations with aging of the amount of hematopoietic tissue in bone marrow from the Anterior Iliac Crest: A study made from 177 cases of sudden death examined by necropsy. Am J Clin Pathol. 1965; 43: 326–31.CrossRefGoogle ScholarPubMed
McKenna, RW, Washington, LT, Aquino, DB, Picker, LJ, Kroft, SH. Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry. Blood. 2001; 98(8): 2498–507.CrossRefGoogle ScholarPubMed
Rimsza, LM, Larson, RS, Winter, SS, Foucar, K, Chong, YY, Garner, KW, et al. Benign hematogone-rich lymphoid proliferations can be distinguished from B-lineage acute lymphoblastic leukemia by integration of morphology, immunophenotype, adhesion molecule expression, and architectural features. Am J Clin Pathol. 2000; 114(1): 66–75.CrossRefGoogle ScholarPubMed
McKenna, RW, Asplund, SL, Kroft, SH. Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry. Leuk Lymphoma. 2004; 45(2): 277–85.CrossRefGoogle ScholarPubMed
Penchansky, L. Pediatric bone marrow. Berlin: Springer; 2004.CrossRefGoogle Scholar
Stuart-Smith, SE, Hughes, DA, Bain, BJ. Are routine iron stains on bone marrow trephine biopsy specimens necessary? J Clin Pathol. 2005; 58(3): 269–72.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×