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Yes
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
The treatment of recurrent ovarian cancer and the role of secondary cytoreductive surgery has been discussed for many years. Three phase III trials focused on that aspect with different results, including patients with the first relapse and a platinum-free interval of at least six months. The GOG 213 trial failed to show an OS benefit for patients with secondary cytoreduction. The interim analysis of the SOC1 trial showed a PFS benefit of 5.5 months (17.4 versus 11.9) favoring surgery, OS data are not mature yet. The DESKTOP III trial revealed an extraordinary OS benefit of 14.5 months for patients with complete resection compared to patients without surgery (60.7 vs. 46.2 months). Therefore, secondary cytoreductive surgery should be offered to suitable patients. The selection of the right patient (e.g. by AGO score) and the right center is the most important step to take to achieve the best results for our patients.
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