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Debate 9B - How Many Cycles of Adjuvant Chemotherapy Should be Administered to Patients with High-risk Stage I Epithelial Ovarian Cancer?

Six Cycles

from Section III - Ovarian Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Based on a systematic review of clinical trials, chemotherapy is currently recommended in all early stages of disease after surgical staging except those with stage IA–B, grade 2 disease [1]. However, the number of cycles of adjuvant chemotherapy remains controversial.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Lawrie, TA, et al. Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer. Cochrane Database Syst Rev 2015;;2015(12):CD004706. https://doi.org/10.1002/14651858.CD004706.pub5Google ScholarPubMed
Bell, J, et al. Gynecologic Oncology Group. Randomized phase III trial of three versus six cycles of adjuvant carboplatin and paclitaxel in early stage epithelial ovarian carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2006;102(3):432439. https://doi.org/10.1016/j.ygyno.2006.06.013CrossRefGoogle ScholarPubMed
Vergote, I, et al. Treatment of patients with early epithelial ovarian cancer. Curr Opin Oncol 2003;15(6):452455. https://doi.org/10.1097/00001622-200311000-00008CrossRefGoogle ScholarPubMed
Chan, JK, et al. The potential benefit of 6 vs. 3 cycles of chemotherapy in subsets of women with early-stage high-risk epithelial ovarian cancer: an exploratory analysis of a Gynecologic Oncology Group study. Gynecol Oncol 2010;116(3):301306. https://doi.org/10.1016/j.ygyno.2009.10.073CrossRefGoogle ScholarPubMed
Chan, JK, et al. Survival after recurrence in early-stage high-risk epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecol Oncol 2010;116(3):307311. https://doi.org/10.1016/j.ygyno.2009.10.074CrossRefGoogle ScholarPubMed

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