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Pre-operative intratympanic gentamicin in patients undergoing retrosigmoid resection of large vestibular schwannomas: a pilot study

Published online by Cambridge University Press:  08 May 2024

Tejal Potdar ,
M. Afiq M. Slim  and
Georgios Kontorinis Open the ORCID record for Georgios Kontorinis [Opens in a new window]
Tejal Potdar
Affiliation:
Medical School, University of Glasgow, Glasgow, UK
M. Afiq M. Slim
Affiliation:
Department of Otorhinolaryngology, Queen Elizabeth University Hospital, Glasgow, UK
Georgios Kontorinis*
Affiliation:
Medical School, University of Glasgow, Glasgow, UK Department of Otorhinolaryngology, Queen Elizabeth University Hospital, Glasgow, UK
*
Corresponding author: Georgios Kontorinis; Email: [email protected]
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Abstract

Purpose

To assess the effects of intratympanic gentamicin on the recovery of patients with large vestibular schwannomas undergoing retrosigmoid resection.

Methods

We conducted a prospective case-control pilot study over 24 months, including 13 patients with large vestibular schwannomas (25–41 mm intracranial diameter); seven patients received intratympanic gentamicin pre-operatively, while six did not. Outcome measures were duration of stay (main), age, gender, vestibular schwannoma size, body mass index and financial costs.

Results

Age had the highest association with longer inpatient stay. The non-gentamicin patients had longer hospital stays, were older, had lower body mass indices and larger vestibular schwannomas. A trend towards shorter stay was seen in patients receiving gentamicin with tumours less than 35 mm in size, but not in patients with larger tumours. Costs were lower for the gentamicin group.

Conclusion

Although not statistically significant, there was a positive trend in patients with vestibular schwannomas greater than 35 mm in size; thus, intratympanic gentamicin as prehabilitation could be considered.

Keywords

Gentamicininpatientenhanced recovery after surgeryrehabilitationvestibular schwannoma
Type
Main Article
Information
The Journal of Laryngology & Otology , First View , pp. 1 - 6
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Georgios Kontorinis takes responsibility for the integrity of the content of the paper

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