This work describes a hyperbolic model for cell-cell repulsion with population dynamics. We consider the pressure produced by a population of cells to describe their motion. We assume that cells try to avoid crowded areas and prefer locally empty spaces far away from the carrying capacity. Here, our main goal is to prove the existence of travelling waves with continuous profiles. This article complements our previous results about sharp travelling waves. We conclude the paper with numerical simulations of the PDE problem, illustrating such a result. An application to wound healing also illustrates the importance of travelling waves with a continuous and discontinuous profile.

The background potential energy (BPE) is the only reservoir that double diffusive instabilities can tap their energy from when developing from an unforced motionless state with no available potential energy (APE). Recently, Middleton and Taylor linked the extraction of BPE into APE to the sign of the diapycnal component of the buoyancy flux, but their criterion can predict only diffusive convection instability, not salt finger instability. Here, we show that the problem can be corrected if the sign of the APE dissipation rate is used instead, making it emerge as the most fundamental criterion for double diffusive instabilities. A theory for the APE dissipation rate for a two-component fluid relative to its single-component counterpart is developed as a function of three parameters: the diffusivity ratio, the density ratio, and a spiciness parameter. The theory correctly predicts the occurrence of both salt finger and diffusive convection instabilities in the laminar unforced regime, while more generally predicting that the APE dissipation rate for a two-component fluid can be enhanced, suppressed, or even have the opposite sign compared to that for a single-component fluid, with important implications for the study of ocean mixing. Because negative APE dissipation can also occur in stably stratified single-component and doubly stable two-component stratified fluids, we speculate that only the thermodynamic theory of exergy can explain its physics; however, this necessitates accepting that APE dissipation is a conversion between APE and the internal energy component of BPE, in contrast to prevailing assumptions.

Let G be a connected semisimple real algebraic group. For a Zariski dense Anosov subgroup $\Gamma <G$ with respect to a parabolic subgroup $P_\theta $, we prove that any $\Gamma $-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $. More generally, we prove that for a Zariski dense $\theta $-transverse subgroup $\Gamma <G$, any $(\Gamma , \psi )$-Patterson–Sullivan measure charges no mass on any proper subvariety of $G/P_\theta $, provided the $\psi $-Poincaré series of $\Gamma $ diverges at its abscissa of convergence. In particular, our result also applies to relatively Anosov subgroups.

Amputation as a life-saving measure for earthquake-trapped patients is supported by WHO and INSARAG guidelines. However, implementing these guidelines in highly stressful contexts can complicate decision-making. This report presents a case of life-saving amputation during the 2023 Turkey earthquake, adhering to recommended guidelines. The 16-year-old patient was trapped for 55 hours in a narrow corridor. Extensive interdisciplinary discussions led to the decision for a field amputation after alternative rescue attempts failed. Consent was obtained from the family, given the patient’s delirium. Meticulous planning and anesthesia using midazolam and ketamine ensured successful amputation with minimal blood loss. Challenges encountered during the disaster response were discussed. Delays in administering antibiotics, a lack of cervical protection, ethical dilemmas, psychological concerns, and legal implications were highlighted. Continued improvement and addressing ethical, legal, and psychological aspects are essential for optimal disaster response outcomes.

This article argues for an as-yet-undiscovered double allusion to Aratus’ Phaenomena (1–5 and 100–7) embedded in Cicero's De diuinatione (1.79). This intertextual link sheds light on a now-lost passage of Cicero's Aratea and raises some questions about the relationship between Cicero's dialogue and Catullus 64.

Digital platforms and social media have expanded the ways in which individuals can exercise their right to freedom of expression and obtain and diffuse information. At the same time, they have become a principal means for haters to express and spread their hate in ways that would have been unthinkable some years ago. Responsive to the challenge, the EU has progressively developed a broad range of instruments and tools to counter online hate speech. This chapter discusses the key characteristics of the EU arrangements made to fight digital hate speech, shedding light on what is a multi-faceted and daunting regulatory task.

Rapid technological development means that the ground on which recent academic studies and public debates about the future of work organisation are based is shifting too rapidly for predictions to be credible. Organisational studies scholars have provided a counterpoint to this futuristic, speculative debate about the world of tomorrow with studies that contextualise seemingly new trends within a longer history of industrial capitalism. In this article, using Moritz Altenried's The Digital Factory (2022) as a starting point, I further explore the historical contextualisation of two aspects of platform capitalism: its de-spatialisation and its use of “autonomy”.

More than two-thirds of women during childbearing years (20–39 years old) are overweight or obese in the United States, with protein intake among 20–49-year-old women being 1.6 times higher than recommended (75.4 g/day versus 46 g/day) that can be considered as a relatively high-protein diet (HPD). Both gestational obesity and HPDs during gestation adversely affect offspring health. This study investigates the impact of HPDs fed during gestation and lactation on obese mothers and their offspring in Wistar rats. Dams randomized to either a normal-protein diet (NPD) or HPD (n = 12/group). Pups from each maternal group were weaned to either NPD or HPD for 17 weeks (n = 12/group). No effect of maternal or weaning diet on food intake, body weight, or body fat/weight ratio was observed. However, NPD dams exhibited higher glucose area under the curve compared with HPD dams (p < 0.03). At weaning, offspring born to NPD dams showed higher fasting plasma glucose (P < 0.03) and insulin/glucose ratio (P = 0.05) than those born to HPD dams. The Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index was higher in offspring born to NPD dams (P < 0.04) and weaned to NPD (P < 0.05) at week 17. These findings underscore the role of high-protein maternal and weaning diets in pregnancy outcomes for obese mothers, particularly in glucose homeostasis, although gestational obesity may overshadow other parameters. Further research is needed to fully understand the impact on both maternal and offspring health and their underlying mechanisms in this context.

This study describes the presence of the royal cucumber Parastichopus regalis (Cuvier, 1817) in The Natural Park of Ria Formosa (NPRF), Portugal. A single individual was observed during a monitoring scuba dive at a depth of 3 m inside this shallow mesotidal lagoon. The most plausible explanation for this occurrence is attributed to the rejection by trawlers when returning to their home port from their fishing grounds. This marine species has a deeper distribution outside the lagoon and is commonly captured as by-catch and subsequently discarded. This study also alerts us to the growing presence of non-indigenous species and the emergent threat of new invasions, highlighting the need to adopt biosecurity measures, like good practices for fishers when dealing with discards to avoid new species introductions in this fragile coastal marine habitat.

Generalized Poisson (GP) distribution was introduced in Consul & Jain ((1973). Technometrics, 15(4), 791–799.). Since then it has found various applications in actuarial science and other areas. In this paper, we focus on the distributional properties of GP and its related distributions. In particular, we study the distributional properties of distributions in the $\mathcal{H}$ family, which includes GP and generalized negative binomial distributions as special cases. We demonstrate that the moment and size-biased transformations of distributions within the $\mathcal{H}$ family remain in the same family, which significantly extends the results presented in Ambagaspitiya & Balakrishnan ((1994). ASTINBulletin: the Journal of the IAA, 24(2), 255–263.) and Ambagaspitiya ((1995). Insurance Mathematics and Economics, 2(16), 107–127.). Such findings enable us to provide recursive formulas for evaluating risk measures, such as Value-at-Risk and conditional tail expectation of the compound GP distributions. In addition, we show that the risk measures can be calculated by making use of transform methods, such as fast Fourier transform. In fact, the transformation method showed a remarkable time advantage over the recursive method. We numerically compare the risk measures of the compound sums when the primary distributions are Poisson and GP. The results illustrate the model risk for the loss frequency distribution.

To capture prey more efficiently, cetaceans can display a wide range of foraging tactics to separate individual prey. Barrier feeding tactics are performed to restrict prey movements, using natural and non-natural barriers and some species can even create barriers with their own bodies. Mud ring feeding has been observed in bottlenose dolphins in Florida Bay and in Chetumal-Corozal Bay, where ring-maker dolphins create ring-shaped mud plumes to encircle fish schools. Here, we document for the first time Guiana dolphins performing the mud ring feeding behaviour in the Cananéia estuarine system, in the southern portion of the state of São Paulo, Brazil. A total of 11 dolphins were recorded in four expeditions through aerial footage engaging in the behaviour. These findings expand our knowledge about the behavioural plasticity of the species and builds upon existing records of mud ring feeding behaviour in cetaceans.

Coronavirus disease 2019 can be indistinguishable from lower respiratory tract infections (LRTIs) caused by other viral and bacterial agents. This likely contributed to antimicrobial use (AU) and antimicrobial resistance (AMR) during the pandemic. Our antimicrobial stewardship program targeted the selection and duration of therapy for LRTIs and led to a reduction in AU and AMR.

While sexual dysfunction is a well-known side effect of taking selective serotonin reuptake inhibitors (SSRIs), in an undetermined number of patients, sexual function does not return to pre-drug baseline after stopping SSRIs. The condition is known as post-SSRI sexual dysfunction (PSSD) and is characterised most commonly by genital numbness, pleasureless or weak orgasm, loss of libido and erectile dysfunction. This article provides a commentary on the incidence and prevalence of PSSD based on a combination of academic literature as well as clinical and research experience. A number of obstacles to quantifying the occurrence of PSSD are outlined including difficulty in designing a suitable study method. Other contextual obstacles include patient embarrassment at raising sexual concerns, the response of healthcare professionals, inability to stop an antidepressant due to withdrawal issues in a proportion of patients and patient unawareness that their sexual difficulties are linked to prior medication compounded by variability of online information and a lack of information aimed at public education. A definition of PSSD with diagnostic criteria has been published. A MedDRA code for PSSD has also been introduced, but this is yet to be adopted by regulators.

The ICD-11 was introduced in January 2022. In chapter 6, “Mental, behavioral and neurodevelopmental disorders” we find the section “Disorders due to substance use and addictive behaviors” (section 6C4). Changes from the ICD-10 in this section include broadening the categories of harmful use and dependence, including more types of substances, and the addition of more behavioral addictions (gaming disorder). These changes have been discussed and debated [1].