Propolis, as a by-product of honey production, has shown several beneficial effects on cardiovascular risks in past randomised controlled trials, although the findings are not conclusive. In this review, we intend to evaluate the effects of propolis consumption on cardiovascular risk factors by conducting a meta-analysis. The Web of Science, Medline and Scopus databases were comprehensively searched until September 2023. Eligible studies were identified by screening, and their data were extracted. Weighted mean differences with a 95 % CI for each outcome were estimated using the random-effects model. This meta-analysis revealed that propolis consumption led to a significant decrease in the levels of TAG (weighted mean differences (WMD): –10·44 mg/dl 95 % CI: –16·58, –4·31; P = 0·001), LDL-cholesterol (WMD: –9·31 mg/dl; 95 % CI: –13·50, –5·12 mg; P < 0·001), fasting blood glucose (WMD: –7·30 mg/dl; 95 % CI: –11·58, –3·02; P = 0·001), HbA1c (WMD: –0·32 %; 95 % CI: –0·60, –0·05; P = 0·01), insulin (WMD: –1·36 μU/ml; 95 % CI: –2·36, –0·36; P = 0·007), homeostatic model assessment for insulin resistance (WMD: –0·39; 95 % CI: –0·74, –0·03; P = 0·020) and systolic blood pressure (WMD: –2·24 mmHg 95 % CI: –4·08, –0·39; P = 0·010), compared with the control groups. Furthermore, propolis consumption had a significant increasing effect on HDL-cholesterol levels (WMD: 2·03 mg/dl; 95 % CI: 0·24, 3·83; P = 0·020). In contrast, the consumption of propolis had no significant effect on total cholesterol and diastolic blood pressure levels. This systematic review and dose–response meta-analysis suggested that propolis intake may be effective in cardiometabolic improvement in adults. Further, well-designed studies are required to confirm and elucidate all aspects of these findings.

We introduce a novel recursive procedure to a neural-network-based subgrid-scale (NN-based SGS) model for large eddy simulation (LES) of high-Reynolds-number turbulent flow. This process is designed to allow an SGS model to be applicable to a hierarchy of different grid sizes without requiring expensive filtered direct numerical simulation (DNS) data: (1) train an NN-based SGS model with filtered DNS data at a low Reynolds number; (2) apply the trained SGS model to LES at a higher Reynolds number; (3) update this SGS model with training data augmented with filtered LES (fLES) data, accommodating coarser filter size; (4) apply the updated NN to LES at a further higher Reynolds number; (5) go back to Step (3) until a target (very coarse) filter size divided by the Kolmogorov length scale is reached. We also construct an NN-based SGS model using a dual NN architecture whose outputs are the SGS normal stresses for one NN and the SGS shear stresses for the other NN. The input is composed of the velocity gradient tensor and grid size. Furthermore, for the application of an NN-based SGS model trained with one flow to another flow, we modify the NN by eliminating bias and introducing a leaky rectified linear unit function as an activation function. The present recursive SGS model is applied to forced homogeneous isotropic turbulence (FHIT) and successfully predicts FHIT at high Reynolds numbers. The present model trained from FHIT is also applied to decaying homogeneous isotropic turbulence and shows an excellent prediction performance.

The objective of this study was to explore barriers and facilitators to utilising a range of food assistance resources as reported by parents living with or at risk for food insecurity (FI), as well as parents’ recommendations for improving utilisation of these resources. Qualitative data from semi-structured interviews about parents’ perspectives on interventions to address FI were analysed using a hybrid deductive/inductive thematic approach. Parents were drawn from the larger Family Matters longitudinal cohort study (N = 1,307), which was recruited from primary care clinics in Minnesota. Forty racially and ethnically diverse parents (Mage = 38.5 years; 97.5% mothers; 85% parents of colour) were recruited by food security level, with ten parents representing each level (i.e. high, marginal, low, very low). Six overarching qualitative themes were identified, which indicated the importance of (1) comfort level seeking assistance; (2) routine screening to assess need; (3) advertising, referrals, and outreach; (4) adequacy of policies and programmes to address need; (5) resource proximity and delivery; and (6) acceptability of foods/benefits provided. With some exceptions, these themes were generally represented from more than one angle (i.e. as barriers, facilitators, recommendations) and raised as relevant across different types of assistance (e.g. federal food assistance programmes, food pantries) and different settings (e.g. schools, healthcare). This study identified key factors influencing food assistance utilisation across multiple dimensions of access. These factors—which range from psychosocial to logistical in nature—should be considered in efforts to expand the reach of food assistance programmes and, in turn, improve food security among families.

To investigate the flame acceleration to detonation in 2.0 and 0.5 mm planar glass combustion chambers, the experiments have been conducted utilising ethylene/oxygen mixtures at atmospheric pressure and temperature. The high-speed camera has been used to record the revolution of flame front and pressure inside the combustion chamber. Different equivalence ratios and ignition locations have been considered in the experiments. The results show that the detonation pressure in the 2 mm thick chamber is nearly three times of Chapman-Jouguet pressure, while detonation pressure in the 0.5 mm thick chamber is only 45.7% of the Chapman-Jouguet value at the stoichiometric mixture. This phenomenon is attributed to the larger pressure loss in the thinner chamber during the detonation propagation. As the value of equivalence ratio is 2.2, the detonation cannot be produced in the 2 mm thick chamber, while the detonation can be generated successfully in the 0.5 mm thick chamber. This phenomenon indicates that the deflagration is easily to be accelerated and transformed into the detonation, due to a larger wall friction and reflection. Besides, the micro-obstacle has been added into the combustor can shorten the detonation transition time and reduces the distance of the detonation transition.

There has been no dearth, since Plutarch’s day at least, of erudite theories about what message the E at Apollo’s temple was meant to convey to visitors. Yet no account so far has added up to a truly compelling answer, not for lack of ingenuity, but because the various approaches have tended so strongly towards the sophisticated and artful, rather than the probable. This article will review why the familiar answers are more impressive than convincing, and will propose in their place a much simpler explanation: namely that the E was meant to represent the mysterious itself, reminding pilgrims that they were entering a realm where logos continued to hold sway, to be sure, as the other inscriptions testified, but where the human intellect must leave room for mantic wisdom, and where logical reasoning must be supplemented with contemplation and meditation upon the enigmatic, the hidden, and the ineffable.