This article highlights the interconnection between Lesbian, Gay, Bisexual, Transgender and Queer (LGBTQ+) research and social policy research, and argues that a greater focus on the welfare needs of gender and sexual minority people can advance the defamilisation and familisation literature. While defamilisation and familisation studies have gained significant attention for examining whether individuals, especially women, have adequate opportunities to balance their work and caregiving responsibilities, most of them pay insufficient attention to the challenges faced by LGBTQ+ individuals in organising their caring and working life. This article addresses this research gap by undertaking three analytical tasks. Firstly, it explores the defamilisation and familisation risks faced by LGBTQ+ individuals. Secondly, it presents a ‘queer life mix framework’ to inform the selection of suitable welfare models to guide governments in tackling these risks. Thirdly, it demonstrates how the ideas of the queer life mix framework can be put into practice.