Criminal violence in Latin American cities is increasing. Meanwhile, with urbanization, greater numbers of people are moving to cities and into the crossfire. What self-protection strategies do residents adopt to keep safe in violent cities? Drawing on qualitative data from Medellín, Colombia, and Monterrey, Mexico, we document the strategies residents use to stay safe. We synthesize insights from studies of civil war, criminal governance, and urban violence to construct an analytical framework to systematically catalog and name these strategies. We posit that the type of violence residents face—indiscriminate or targeted—influences the strategies they pursue. Responding to either the indiscriminate or targeted form, residents employ survival strategies to avoid, withstand, or confront violence. Our research underscores the centrality of agency for residents’ “staying power” amid urban violence.